Abstract: There is provided inter alia a polypeptide comprising an immunoglobulin chain variable domain which binds to IL-6R, wherein the immunoglobulin chain variable domain comprises three complementarity determining regions (CDR1-CDR3) and four framework regions (FR1-FR4), wherein CDR1-CDR3 and FR1-FR4 are as defined in the specification.

Abstract: There are provided inter alia polypeptides capable of inhibiting IL-7 and/or L-TSLP binding to IL-7R (IL-7R), as well as to constructs and pharmaceutical compositions comprising these polypeptides.

Abstract: There is provided inter alia a polypeptide comprising an immunoglobulin chain variable domain which binds to IL-23, wherein the immunoglobulin chain variable domain comprises three complementarity determining regions (CDR1-CDR3) and four framework regions (FR1-FR4), wherein CDR1 comprises a sequence sharing 60% or greater sequence identity with SEQ ID NO: 1, CDR2 comprises a sequence sharing 50% or greater sequence identity with SEQ ID NO: 2 and CDR3 comprises a sequence sharing 50% or greater sequence identity with SEQ ID NO: 3.

Abstract: An integrated circuit die includes a silicon chromium (SiCr) thin film resistor disposed on a first oxide layer. The SiCr thin film resistor has a resistor body and a resistor head. A second oxide layer overlays the SiCr thin film resistor. The second oxide layer has an opening exposing a surface of the resistor head. A metal pad is disposed in the opening in the second oxide layer and is contact with the surface of the resistor head exposed by the opening. Further, an interlevel dielectric layer is disposed on the second oxide layer overlaying the SiCr thin film resistor. A metal-filled via extends from a top surface of interlevel dielectric layer through the interlevel dielectric layer and contacts the metal pad disposed in the opening in the second oxide layer.

Abstract: There is provided inter alia a polypeptide comprising an immunoglobulin chain variable domain which binds to IL-23, wherein the immunoglobulin chain variable domain comprises three complementarity determining regions (CDR1-CDR3) and four framework regions (FR1-FR4), wherein CDR1 comprises a sequence sharing 60% or greater sequence identity with SEQ ID NO: 1, CDR2 comprises a sequence sharing 50% or greater sequence identity with SEQ ID NO: 2 and CDR3 comprises a sequence sharing 50% or greater sequence identity with SEQ ID NO: 3.

Abstract: There is provided inter alia a polypeptide comprising an immunoglobulin chain variable domain which binds to IL-6R, wherein the immunoglobulin chain variable domain comprises three complementarity determining regions (CDR1-CDR3) and four framework regions (FR1-FR4), wherein CDR1-CDR3 and FR1-FR4 are as defined in the specification.

Abstract: Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

Abstract: Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

Abstract: Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

Abstract: The vehicle steering column has a rake adjustment and a telescope adjustment. The adjustment mechanism includes a compression bracket with a telescope slot, a rake bracket with a rake slot and a rake bolt that passes through the telescope slot and the rake slot. A wedge lock is mounted on the rake bolt and positioned in the rake slot and the telescope slot. Rake and telescope teeth on the wedge lock are held out of engagement with a rake tooth rack and a telescope tooth rack during rake and telescope adjustment. The rake bolt is tightened to hold a selected adjustment position and the telescope teeth on the wedge lock engage the telescope tooth rack. During a collision the rake teeth on the wedge lock are moved into engagement with the rake tooth rack to fix the rake and telescope adjustments.

Abstract: The vehicle steering column has a rake adjustment and a telescope adjustment. The adjustment mechanism includes a compression bracket with a telescope slot, a rake bracket with a rake slot and a rake bolt that passes through the telescope slot and the rake slot. A wedge lock is mounted on the rake bolt and positioned in the rake slot and the telescope slot. Rake and telescope teeth on the wedge lock are held out of engagement with a rake tooth rack and a telescope tooth rack during rake and telescope adjustment. The rake bolt is tightened to hold a selected adjustment position and the telescope teeth on the wedge lock engage the telescope tooth rack. During a collision the rake teeth on the wedge lock are moved into engagement with the rake tooth rack to fix the rake and telescope adjustments.

Abstract: The vehicle steering column has a rake adjustment and a telescope adjustment. The adjustment mechanism includes a compression bracket with a telescope slot, a rake bracket with a rake slot and a rake bolt that passes through the telescope slot and the rake slot. A wedge lock is mounted on the rake bolt and positioned in the rake slot and the telescope slot. Rake and telescope teeth on the wedge lock are held out of engagement with a rake tooth rack and a telescope tooth rack during rake and telescope adjustment. The rake bolt is tightened to hold a selected adjustment position and the telescope teeth on the wedge lock engage the telescope tooth rack. During a collision the rake teeth on the wedge lock are moved into engagement with the rake tooth rack to fix the rake and telescope adjustments.

Abstract: A position control apparatus for an adjustable motor vehicle steering column including a friction clamp, a control shaft rotatable between locked and unlocked positions, a hollow rectangular frame moveable relative to the control shaft when the steering column is adjusted, a first toothed pawl a second toothed pawl, and an elastic bushing resiliently supporting the first and second toothed pawls on the control shaft inside of the rectangular frame. When the control shaft is rotated to its locked position the friction clamp frictionally captures the adjusted position of the steering column. The pawls have gear sectors thereon which are relatively angularly offset by one-half tooth pitch. When the control shaft is rotated to its locked position, the one-half tooth pitch offset assures that at least one of the gear sectors will mesh with a rack gear on the rectangular frame even if the other engages the rack gear peak-to-peak.

Abstract: A steering column for a motor vehicle having a gear box of an electric power assist apparatus in front of the steering column. The steering column includes a rigid mast jacket consisting of a short tubular sleeve and a bracket attached to the tubular sleeve having a pair of laterally separated guides straddling the gear box. A pair of lugs on the gear box cooperate with a pair of elongated slots in the guides in connecting the mast jacket to the gear box for vertical pivotal movement and for linear translation. A longitudinally collapsible steering shaft is rotatably supported on the tubular sleeve with a steering hand wheel at one end and a flexible coupling at the other end connecting the steering shaft to an input shaft on the gear box. The tubular sleeve is connected to the vehicle body by a clamp which releases the tubular sleeve for a collapse stroke of the mast jacket. The mast jacket protects the steering shaft against beam bending during the collapse stroke.

Abstract: A shaft coupling including a socket, a first shaft, a plug on a second shaft seated in the socket, and a clamp operative to clamp together the first and the second shafts in the direction of a longitudinal centerline of the shaft coupling to prevent dislodgment of the plug from the socket. The clamp includes an annular first flange on the first shaft, an annular second flange on the second shaft facing the first flange, oppositely facing frustoconical shoulders on the first and the second flanges, a plurality of clamp jaws pivotally mounted on the first shaft arrayed symmetrically around the first and the second flanges each having a closed position inducing radial thrust on the oppositely facing frustoconical shoulders, and springs biasing each of the clamp jaws toward its closed position.

Abstract: A motor vehicle headlamp comprising a dished body having an ellipsoidal inner reflective surface. A lamp filament is disposed at an inner focal point of the surface. A diverging meniscus lens element having a smooth convex rear surface is disposed between the reflective surface and a front cover. The lens element has a smooth concave outer surface, although the latter may be a concave fresnel lens. The convex rear surface of the lens element reduces the risk of unwanted light scatter compared with the use of a concave rear surface.