Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

Abstract: Provided are devices, compositions, and methods for surface disinfection and decontamination; the devices generally adapted to contain a single or multi-component indicator composition, and optionally a disinfectant composition, and to dispense the indicator composition and optional disinfectant composition to a disinfectant solution, a surface, or a disinfectant article upon actuation of the device; also provided is an article of manufacture in the form of a removable cartridge adapted to fit a device described here, which may be pre-filled with a single or multi-component indicator composition as described here, and/or with a disinfectant composition, and one or more optional additives.

Abstract: Novel therapeutic protocols are provided relating to the use of an anti-IL-6 antibody, e.g., Clazakizumab, in order to prevent, stabilize, reduce or arrest antibody mediated rejection responses in patients receiving solid organ transplants, e.g., patients receiving transplanted kidney, heart, liver, lungs, pancreas, intestines or combinations of any of the foregoing. Also novel therapeutic protocols are provided pertaining to the use of an anti-IL-6 antibody, e.g., Clazakizumab, as part of a desensitization protocol for treating highly sensitized subjects waiting for and/or after allograft transplants, e.g., patients who are to receive solid organ transplants, e.g., kidney, heart, liver, lungs, pancreas, intestines, skin or combinations of any of the foregoing. The foregoing treatments may be effected in combination with one or more other immunosuppressant regimens or other desensitization procedures.

Abstract: A filter element analysis system for analyzing a filter element within a vehicle, the system including various filter sensors so as to provide information regarding various filter element parameters, a locator which configured provide vehicle position information such that conditions regarding the vehicle environment can be tracked and correlated to the location, as well as a means for transmitting information to a remote server for analysis and tracking of the filter element information with regard to environmental conditions such that a filter element status, remaining filter life, or particle load and replacement timeline can be calculated and updated so as to provide more accurate predictive models of the filter element conditions. As well as provide alerts regarding the need and scheduling of replacement or cleaning of a particular filter element.

Abstract: A door interface system for a vehicle door includes a sensor and a visual indicator. The sensor may be a proximity sensor and may be positioned proximate to the visual indicator such that it will detect an object proximate to the proximity sensor. The visual indicator may convey the position of the sensor and/or a status of the vehicle door. The door interface system is configured to control the vehicle door based at least in part on detecting an object proximate the visual indicator.

Abstract: A sound muffling chamber covers a nose and mouth in an airtight manner. The sound muffling chamber includes a microphone that detects vocal sound waves in the sound muffling chamber and generates a voice signal. A digital signal processing system analyzes the voice signal and generates a voice cancellation signal. A sound silencing chamber includes a speaker that generates out of phase sound waves in response to the voice cancellation signal that superimposes on and cancels the vocal sound waves. A sound decelerator is positioned between the sound muffling chamber and the sound silencing chamber and configured to increase a traveling time of the vocal sound waves such that the vocal sound waves' arrival at the sound silencing chamber may be synchronized with the arrival of a voice cancellation signal. The sound muffling chamber may include inflatable cells separated by slats such that the sound muffling chamber is foldable.

Abstract: An endotracheal or tracheostomy tube with a cuff assembly includes a cuff pressure regulator and a leak detection system. Pressure sensors monitor and measure a tracheal wall pressure and pressures in the cuff assembly. An abnormal reading from the pressure sensors may initiate a cuff-pressure adjusting process. The leak detection system detects an air leak in the seal between the cuff assembly and the tracheal wall. A scented film with a predetermined scent is positioned on an inferior portion of the cuff assembly, distally from the seal with the tracheal wall. An air leak is indicated when the predetermined scent is detected in air in the trachea proximal to the cuff assembly. An air-circulation device generates air flow into the trachea such that a new batch of air may be sampled and tested. The detection of an air leak may initiate a cuff-pressure adjusting process.

Abstract: A cuff assembly for a tracheostomy tube includes an outer bladder and an inner cuff. The inner cuff is positioned adjacent to the tracheostomy tube, and the outer bladder is positioned adjacent to the inner cuff. The outer bladder is made with a less elastic material and operates at a higher relative pressure. The inner cuff is made with a more elastic or hyper-elastic material and operates at a lower relative pressure. A secondary airflow opening is formed on a lateral wall of the tracheostomy tube between the cuff assembly and a main distal opening of the tracheostomy tube.

Abstract: An airway device includes an outertube and a scope channel partially enclosed by the outertube. An intraluminal space in the outertube, not occupied by the scope channel, provides a passageway for air flow to the patient. An esophageal cuff is disposed distally on the scope channel. When inflated, the esophageal cuff secures the airway device in the proximal esophagus of the patient and helps to prevent gastric reflux by mechanically blocking gastric content from entering into the larynx. An inflatable bladder is attached at an anterior surface of the scope channel between the esophageal cuff and a distal opening of the outertube. When inflated, the bladder forms a tubular ring that pushes against the epiglottis and/or other soft tissue towards a wall of the hypopharynx to produce an unhindered air passage into the patient's trachea.

Abstract: A cuff assembly for an airway tube includes an outer bladder and an inner cuff. The inner cuff is positioned adjacent to the airway tube, and the outer bladder is positioned adjacent to the inner cuff. The outer bladder is made with a less elastic material and operates at a higher relative pressure. The inner cuff is made with a more elastic or hyper-elastic material and operates at a lower relative pressure. A pressure controller independently adjusts the pressure within the inner cuff and the outer bladder. A secretion collection receptacle is formed by the cuff assembly and is evacuated via a suction catheter or channel.

Abstract: Described is a neural network accelerator tile for exploiting input sparsity. The tile includes a weight memory to supply each weight lane with a weight and a weight selection metadata, an activation selection unit to receive a set of input activation values and rearrange the set of input activation values to supply each activation lane with a set of rearranged activation values, a set of multiplexers including at least one multiplexer per pair of activation and weight lanes, where each multiplexer is configured to select a combination activation value for the activation lane from the activation lane set of rearranged activation values based on the weight lane weight selection metadata, and a set of combination units including at least one combination unit per multiplexer, where each combination unit is configured to combine the activation lane combination value with the weight lane weight to output a weight lane product.

Abstract: A hand-held test meter for use with an analytical test strip for the determination of an analyte in a bodily fluid sample includes a test meter housing with a housing outer surface and a distal end, a PCB disposed within the test meter housing; a SPC disposed in the test meter housing, and a metal shield plate securely attaching the strip port connector to the PCB. The SPC includes a SPC housing with at least one contact stopper rib, and plurality of electrical contacts (e.g., electrical contacts with a T-bar shaped distal end) disposed in the SPC housing. Each of the plurality of electrical contacts has a distal end and a test strip contact surface (TSCS). The TSCS of the electrical contact is configured for operable contact with an analytical test strip received in the SPC and the TSCS of the electrical contact is a smooth dimpled surface.