Abstract: Systems and methods for sequential deployment of a prosthetic valve using a delivery catheter are described. The delivery catheter may include a deployment assembly including an end cone, a distal sleeve, a prosthetic support, an anchor sleeve and an anchor support. The delivery catheter may further include a handle having a manipulator including a guide that is connect to the deployment assembly with a force transmission tube. The guide may have various channels for interfacing with a protrusion of the handle and may be guided by the protrusion to sequentially deploy the prosthetic valve from the deployment assembly. For example, the guide may cause the distal sleeve to release a distal end of the prosthetic valve and subsequently cause an anchor support to release a proximal end of the prosthetic valve.

Abstract: A modular catheter system including a sheath projecting distally from a delivery catheter having a main body module An inner core module carrying a stent thereon, the inner core being axially movable through the main body of the delivery catheter and the delivery catheter sheath, a handle member supported by the main body of the delivery catheter, the handle member being selectively axially engageable with the inner core such that the handle member and the inner core move together in an axial direction when the handle member is engaged with the inner core; and an adjustment member supported by the main body, the adjustment member being configured such that rotation of the adjustment member causes the adjustment member to move axially along the main body by either axially sliding the handle member relative to the main body or by rotating the adjustment member.

Abstract: An electronic computing device receives a request from a third party for status information for a financial transaction. The request includes an identifier for the third party and an identifier for the financial transaction. The third party is authenticated using the identifier for the third party. A data store is queried using the identifier for the financial transaction to determine the status information for the financial transaction. Any contingency information associated with the financial transaction is updated. The status information and contingency information are returned to the third party.

Abstract: A locking assembly for releasably coupling a first elongate member to a second elongate member is provided. The locking assembly can include a first lumen for anchoring the locking assembly to a catheter and a second lumen for releasably retaining a guidewire to the locking assembly. A release member can interface with the locking assembly and apply a force that decouples the guidewire from the locking assembly.

Abstract: Various technologies described herein pertain to generating an occupancy grid movie for utilization in motion planning for the autonomous vehicle. The occupancy grid movie can be generated for a given time and can include time-stepped occupancy grids for future times that are at predefined time intervals from the given time. The time-stepped occupancy grids include cells corresponding to regions in an environment surrounding the autonomous vehicle. Probabilities can be assigned to the cells specifying likelihoods that the regions corresponding to the cells are occupied at the future times. Moreover, cached query objects that respectively specify indices of cells of a grid occupied by a representation of an autonomous vehicle at corresponding orientations are described herein. An occupancy grid for the environment surrounding the autonomous vehicle can be queried to determine whether cells of the occupancy grid are occupied utilizing a cached query object from the cache query objects.

Abstract: Systems and methods for monitoring and staging sleep using cardiac and respiration information are disclosed. An exemplary system comprises a storage device to store a trained hybrid sleep detection and classification model that comprise a plurality of trained machine-learning models each trained to map input cardiac and respiratory data into one of multiple distinct model-specific awake or sleep classes, and a trained regression model to combine the model-specific awake or sleep classes to a composite awake or sleep classification. A sleep detector applies patient cardiac and respiratory information to the trained hybrid sleep detection and classification model to determine a composite awake or sleep classification for the patient. The composite awake or sleep classification is used to diagnose medical conditions including sleep apnea.

Abstract: Systems and methods for sequential deployment of a prosthetic valve using a delivery catheter are described. The delivery catheter may include a deployment assembly including an end cone, a distal sleeve, a prosthetic support, an anchor sleeve and an anchor support. The delivery catheter may further include a handle having a manipulator including a guide that is connect to the deployment assembly with a force transmission tube. The guide may have various channels for interfacing with a protrusion of the handle and may be guided by the protrusion to sequentially deploy the prosthetic valve from the deployment assembly. For example, the guide may cause the distal sleeve to release a distal end of the prosthetic valve and subsequently cause an anchor support to release a proximal end of the prosthetic valve.

Abstract: A vehicle is received in a stationary controlled area of a controlled testing environment. Simulation inputs corresponding to a simulated scene are generated and transmitted to the vehicle. The vehicle applies torque in response. A vehicle control mechanism of the controlled testing environment, such as a chassis dynamometer, a motorized treadmill, or a lift, keeps the vehicle within the stationary controlled area during the test despite the torque applied by the vehicle. A path of the vehicle within the simulated scene is determined based on the applied torque, based upon which the vehicle's navigation system is calibrated.

Abstract: Various technologies described herein pertain to generating an occupancy grid movie for utilization in motion planning for the autonomous vehicle. The occupancy grid movie can be generated for a given time and can include time-stepped occupancy grids for future times that are at predefined time intervals from the given time. The time-stepped occupancy grids include cells corresponding to regions in an environment surrounding the autonomous vehicle. Probabilities can be assigned to the cells specifying likelihoods that the regions corresponding to the cells are occupied at the future times. Moreover, cached query objects that respectively specify indices of cells of a grid occupied by a representation of an autonomous vehicle at corresponding orientations are described herein. An occupancy grid for the environment surrounding the autonomous vehicle can be queried to determine whether cells of the occupancy grid are occupied utilizing a cached query object from the cache query objects.

Abstract: Systems and methods are disclosed to adjust one or more determined boundaries of a display of received physiologic information of a patient based on different first and second ranges of physiologic information, including determining first and second boundaries of a first range of the received physiologic information and first and second boundaries of a second range of the received physiologic information, wherein the second range is within the first range. The one or more determined boundaries of the display can be provided for presentation to a user, including the determined first and second boundaries of the first range and the determined first and second boundaries of the second range.

Abstract: Systems and methods for electrically stimulating a patient's cardiac conduction system at selected locations based on heart sounds are disclosed. A medical-device system includes a data receiver to receive heart sound information sensed from a patient, an electrostimulation circuit to deliver electrostimulation to the cardiac conduction system, and a controller circuit to generate, from the heart sound information sensed in response to the electrostimulation being delivered respectively to two or more candidate locations at or near the cardiac conduction system, heart sound metrics respectively for the two or more candidate locations. Based on the heart sound metrics, the controller circuit selects at least one of the candidate locations as a pacing location for subsequent electrostimulation. Electrostimulation can be delivered to the selected pacing location to restore cardiac synchrony.

Abstract: Systems and methods for recognizing and classifying breathing patterns based on spatial analysis of chest wall or abdominal movement or acceleration are described. A medical-device system comprises a receiver circuit to receive respiration information of a patient, and a breath analyzer circuit to determine from the respiration information two or more spatial respiration components, such as accelerations of chest wall or abdominal movement in respective directions along the anatomical axes. The breath analyzer circuit can classify a breathing pattern as one of either chest breathing or diaphragmatic breathing based on the determined spatial respiration components. The classified breathing pattern can be used for detecting a physiological event such as worsening heart failure or for assessing the patient's risk of having metabolic disorders.

Abstract: An electronic computing device receives a request from a third party for status information for a financial transaction. The request includes an identifier for the third party and an identifier for the financial transaction. The third party is authenticated using the identifier for the third party. A data store is queried using the identifier for the financial transaction to determine the status information for the financial transaction. Any contingency information associated with the financial transaction is updated. The status information and contingency information are returned to the third party.

Abstract: The invention provides a delivery catheter (12) for a stent valve (10), the delivery catheter has a distal portion (14) insertable into an anatomy, the distal portion comprises an accommodation region (18) for accommodating a stent-valve for delivery into the anatomy, the delivery catheter further comprises at least one sheath (20; 22) that is translatable between a closed position for at least partly closing the accommodation region and an open position for at least partly opening the accommodation region.

Abstract: Systems and methods are provided for sequential deployment of a cardiac implant such as a prosthetic heart valve using a catheter system with an elongated shaft with a deployment assembly one end and a handle on the other end. The deployment assembly may include a one or more sleeves and anchor supports that maintain the cardiac implant in a partially collapsed state. The handle may include a first actuator and a second actuator each designed to rotate with respect to a body of the handle. The first actuator may be rotated to cause the elongated shaft to arch. The second actuator may be rotated in a locked position to cause the deployment assembly to rotate or move axially or may be rotated in an unlocked position to cause the sleeve and anchor support on the deployment assembly to move thereby permitting the cardiac implant to expand to an expanded state.

Abstract: Systems and methods for sequential deployment of a prosthetic valve using a delivery catheter are described. The delivery catheter may include a deployment assembly including an end cone, a distal sleeve, a prosthetic support, an anchor sleeve and an anchor support. The delivery catheter may further include a handle having a manipulator including a guide that is connect to the deployment assembly with a force transmission tube. The guide may have various channels for interfacing with a protrusion of the handle and may be guided by the protrusion to sequentially deploy the prosthetic valve from the deployment assembly. For example, the guide may cause the distal sleeve to release a distal end of the prosthetic valve and subsequently cause an anchor support to release a proximal end of the prosthetic valve.

Abstract: A vehicle is received in a stationary controlled area of a controlled testing environment. Simulation inputs corresponding to a simulated scene are generated and transmitted to the vehicle. The vehicle applies torque in response. A vehicle control mechanism of the controlled testing environment, such as a chassis dynamometer, a motorized treadmill, or a lift, keeps the vehicle within the stationary controlled area during the test despite the torque applied by the vehicle. A path of the vehicle within the simulated scene is determined based on the applied torque, based upon which the vehicle's navigation system is calibrated.

Abstract: A vehicle is received in a stationary controlled area of a controlled testing environment. Simulation inputs corresponding to a simulated scene are generated and transmitted to the vehicle. The vehicle applies torque in response. A vehicle control mechanism of the controlled testing environment, such as a chassis dynamometer, a motorized treadmill, or a lift, keeps the vehicle within the stationary controlled area during the test despite the torque applied by the vehicle. A path of the vehicle within the simulated scene is determined based on the applied torque, based upon which the vehicle's navigation system is calibrated.

Abstract: Various technologies described herein pertain to generating an occupancy grid movie for utilization in motion planning for the autonomous vehicle. The occupancy grid movie can be generated for a given time and can include time-stepped occupancy grids for future times that are at predefined time intervals from the given time. The time-stepped occupancy grids include cells corresponding to regions in an environment surrounding the autonomous vehicle. Probabilities can be assigned to the cells specifying likelihoods that the regions corresponding to the cells are occupied at the future times. Moreover, cached query objects that respectively specify indices of cells of a grid occupied by a representation of an autonomous vehicle at corresponding orientations are described herein. An occupancy grid for the environment surrounding the autonomous vehicle can be queried to determine whether cells of the occupancy grid are occupied utilizing a cached query object from the cache query objects.

Abstract: An electronic computing device receives a request from a third party for status information for a financial transaction. The request includes an identifier for the third party and an identifier for the financial transaction. The third party is authenticated using the identifier for the third party. A data store is queried using the identifier for the financial transaction to determine the status information for the financial transaction. Any contingency information associated with the financial transaction is updated. The status information and contingency information are returned to the third party.