Abstract: dsRNAi oligonucleotides can be used in methods for the treatment of NASH, preferably the advanced fibrotic and/or cirrhotic stages thereof, using dosage regimens comprising a loading phase followed by a maintenance phase.

Abstract: The present invention relates to the use of cannabidiol (CBD) for the treatment of seizures associated with rare epilepsy syndromes. In particular the seizures associated with rare epilepsy syndromes that are treated are those which are experienced inpatients diagnosed with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) with DEPDC5 gene mutation. In a further embodiment the types of seizures include tonic, tonic-clonic and focal seizures without impairment. Preferably the dose of CBD is between 5 mg/kg/day to 50 mg/kg/day.

Abstract: The present invention relates to the use of cannabidiol (CBD) for the treatment of seizures associated with rare epilepsy syndromes. In particular the seizures associated with rare epilepsy syndromes that are treated are those which are experienced inpatients diagnosed with Rett syndrome. In a further embodiment the types of seizures include tonic, tonic-clonic, absence seizures and focal seizures with impairment. Preferably the dose of CBD is between 5 mg/kg/day to 50 mg/kg/day.

Abstract: The present invention relates to the use of cannabidiol (CBD) for the treatment of seizures associated with rare epilepsy syndromes. In particular the seizures associated with rare epilepsy syndromes that are treated are those which are experienced inpatients with mutations on GR1N2B and CACNA1H genes. In a further embodiment the types of seizures include tonic-clonic, absence and focal seizures with impairment. Preferably the dose of CBD is between 5 mg/kg/day to 50 mg/kg/day.

Abstract: The present invention relates to the use of cannabidiol (CBD) for the treatment of seizures associated with rare epilepsy syndromes. In particular the seizures associated with rare epilepsy syndromes that are treated are those which are experienced inpatients with mutation in the potassium channel (KCN) gene. In a further embodiment the types of seizures include tonic, tonic-clonic, absence and focal seizures with impairment. Preferably the dose of CBD is between 5 mg/kg/day to 50 mg/kg/day.

Abstract: The present invention relates to the use of cannabidiol (CBD) in the treatment of patients with childhood-onset epilepsy who are concurrently taking caffeine. Where the CBD is used in combination with caffeine, caution should be taken. For example, the dose of either the CBD and/or caffeine may be required to be reduced. Moreover, the patient may need to be monitored for side effects of said drug-drug interaction. Preferably the CBD used is in the form of a highly purified extract of cannabis such that the CBD is present at greater than 95% of the total extract (w/w) and the other components of the extract are characterised. In particular the cannabinoid tetrahydrocannabinol (THC) has been substantially removed, to a level of not more than 0.15% (w/w) and the propyl analogue of CBD, cannabidivarin, (CBDV) is present in amounts of up to 1%. Alternatively, the CBD may be a synthetically produced CBD.

Abstract: The tire sensing and analysis system may comprise a measurement device and local application software. The measurement device may make contact with a tire of a vehicle such that the measurement device is positioned at a specific distance and orientation relative to the tire. The measurement device may capture multiple images of the tire using an RGB camera and a pair of infrared cameras. The local application software may analyze the images and may construct a 3D mesh describing the 3-dimensional contours of the tread. The local application software may determine a tread depth and may display status and warning messages on a display unit that is coupled to the measurement device. The measurements may be communicated to remote application software for additional analysis. As non-limiting examples, the remote application software may detect specific tire wear patterns and may transmit a report to share results of the analysis.

Abstract: An online system receives contextual information for a goal-oriented environment at a current time and generates Q-value predictions that indicate likelihoods that one or more participants will reach the desired goal. The Q-value for a current time may also be interpreted as the value of the actions taken at the current time with respect to the desired goal. The online system generates Q-value predictions for a current time by applying an approximator network to the contextual information for the current time. In one instance, the approximator network is a machine learning model neural network model trained by a reinforcement learning process. The reinforcement process allows the approximator network to incrementally update the Q-value predictions given new information throughout time, and results in a more computationally efficient training process compared to other types of supervised or unsupervised machine learning model processes.

Abstract: The tire sensing and analysis system may comprise a measurement device and local application software. The measurement device may make contact with a tire of a vehicle such that the measurement device is positioned at a specific distance and orientation relative to the tire. The measurement device may capture multiple images of the tire using an RGB camera and a pair of infrared cameras. The local application software may analyze the images and may construct a 3D mesh describing the 3-dimensional contours of the tread. The local application software may determine a tread depth and may display status and warning messages on a display unit that is coupled to the measurement device. The measurements may be communicated to remote application software for additional analysis. As non-limiting examples, the remote application software may detect specific tire wear patterns and may transmit a report to share results of the analysis.

Abstract: Rheological measurement systems for use with systems including pressurized polymer melts and/or other viscous materials are described. In one embodiment, a rheometer is connected to an associated system with a bent, curved, or bendable tube to permit the rheometer to measure rheological properties in locations where the rheometer could not otherwise be located due to the presence of obstructions. Embodiments including rigid straight tubes for connecting a rheometer to an associated system are also described. In another embodiment, a flow-through rheometer is connected to an industry standard ½-20 thermowell aperture that is typically used for attaching temperature and pressure probes to a vessel containing a viscous material such as an extruder or injection molding system.

Abstract: Rheological measurement systems for use with systems including pressurized polymer melts and/or other viscous materials are described. In one embodiment, a rheometer is connected to an associated system with a bent, curved, or bendable tube to permit the rheometer to measure rheological properties in locations where the rheometer could not otherwise be located due to the presence of obstructions. Embodiments including rigid straight tubes for connecting a rheometer to an associated system are also described. In another embodiment, a flow-through rheometer is connected to an industry standard ½-20 thermowell aperture that is typically used for attaching temperature and pressure probes to a vessel containing a viscous material such as an extruder or injection molding system.

Abstract: Systems and methods for thermal management for high power density EMI shielded electronic devices. In one embodiment, an electronic module comprises: a circuit board; at least one integrated circuit mounted to the circuit board; at least one electro-magnetic interference (EMI) shield fence mounted to the circuit board, wherein the at least one integrated circuit is mounted within a perimeter defined by the EMI shield fence; a heatsink EMI shield lid secured onto the at least one EMI shield fence, wherein the heatsink EMI shield lid seals the at least one integrated circuit within the at least one EMI shield fence; wherein the heatsink EMI shield lid comprises a spring loaded thermal interface in conductive thermal contact with the at least one integrated circuit.

Abstract: A method of calibrating a printer using a reflective scanner is disclosed. Because the reflective scanner used for calibration may only be able to accurately measure a limited density range that is less than the full density range of the printer, some information from the reflective scanner is disregarded or deemphasized during the calibration process. A calibration page is printed and scanned. Lookup tables (LUTs) that comprise the printer calibration values are updated based on adjustments calculated from the scanner for density regions where the scanner produces relatively accurate measurements, but updated based on the preexisting settings for density regions where the scanner produces relatively inaccurate measurements. In transitions regions between accurate and inaccurate regions, the LUTs are adjusted based on a combination of measurements from the scanner and the preexisting settings.

Abstract: A mobile entertainment and announcement system has a trailer base and a trailer body mounted on the trailer base. A trailer hitch projecting from a forward end of the trailer base allows the mobile entertainment and announcement system to be transported to a desired venue by connecting the trailer hitch to a vehicle. A telescoping boom is supported by at least one of the trailer base and the trailer body, and is adapted to move from a transport position to a set-up position and to a broadcast position. At least one broadcast speaker is mounted on the telescoping boom when the telescoping boom is in a set-up position, so that when the telescoping boom is moved from the transport position to the broadcast position, the broadcast speaker is moved to a higher elevation above the trailer base. An audio component housed in the trailer body is connected to the broadcast speaker for transmitting audio content to an audience over a larger area.

Abstract: An on-board system for location estimation and communication for a vehicle. In some embodiments, the on-board system includes a global navigation satellite system receiver, an inertial sensing system, a wireless receiver, and a processing circuit. The wireless receiver includes at least one of a cellular communications receiver, and a wireless local area networking receiver.

Abstract: Disclosed herein is a method including receiving, via a bridge system including a first adapter and a second adapter, a service set identifier and a password of a capture device and discovering the capture device via the first adapter and the second adapter of the bridge system. Based on a comparison of a first signal-to-noise ratio between the first adapter and the capture device with a second signal-to-noise ratio between the second adapter and the capture device, the method includes assigning one of the first adapter and the second adapter as a host adapter in the bridge system to communicate with the capture device, transmitting, from the host adapter, a signal to the capture device to prioritize a frequency band to use for communication with the bridge system, receiving, via the frequency band, IP packets from the capture device at the host adapter and forwarding the IP packets from the bridge system to a client device.

Abstract: A mobile entertainment and announcement system has a trailer base and a trailer body mounted on the trailer base. A trailer hitch projecting from a forward end of the trailer base allows the mobile entertainment and announcement system to be transported to a desired venue by connecting the trailer hitch to a vehicle. A telescoping boom is supported by at least one of the trailer base and the trailer body, and is adapted to move from a transport position to a set-up position and to a broadcast position. At least one broadcast speaker is mounted on the telescoping boom when the telescoping boom is in a set-up position, so that when the telescoping boom is moved from the transport position to the broadcast position, the broadcast speaker is moved to a higher elevation above the trailer base. An audio component housed in the trailer body is connected to the broadcast speaker for transmitting audio content to an audience over a larger area.

Abstract: Rheological measurement systems for use with systems including pressurized polymer melts and/or other viscous materials are described. In one embodiment, a rheometer is connected to an associated system with a bent, curved, or bendable tube to permit the rheometer to measure rheological properties in locations where the rheometer could not otherwise be located due to the presence of obstructions. Embodiments including rigid straight tubes for connecting a rheometer to an associated system are also described. In another embodiment, a flow-through rheometer is connected to an industry standard ½-20 thermowell aperture that is typically used for attaching temperature and pressure probes to a vessel containing a viscous material such as an extruder or injection molding system.

Abstract: Systems and methods for thermal management for high power density EMI shielded electronic devices. In one embodiment, an electronic module comprises: a circuit board; at least one integrated circuit mounted to the circuit board; at least one electro-magnetic interference (EMI) shield fence mounted to the circuit board, wherein the at least one integrated circuit is mounted within a perimeter defined by the EMI shield fence; a heatsink EMI shield lid secured onto the at least one EMI shield fence, wherein the heatsink EMI shield lid seals the at least one integrated circuit within the at least one EMI shield fence; wherein the heatsink EMI shield lid comprises a spring loaded thermal interface in conductive thermal contact with the at least one integrated circuit.