Abstract: This relates generally to intelligent automated assistants and, more specifically, to provide a handsfree notification management system. An example method includes displaying one or more notifications by the electronic device. In response to displaying the one or more notifications, the method includes detecting a visual interaction of a user with the one or more notifications, identifying a notification from the one or more notifications based on the visual interaction, determining a time-interval of the visual interaction with the notification, determining one or more actions associated with the notification based on the time-interval of the visual interaction with the notification, and performing the one or more actions.

Abstract: A method of preventing transmission of a virus from a mammalian subject. The method includes applying to a surface of the nasal cavity of the mammalian subject an aqueous composition. The aqueous composition includes a surfactant and a hydroxycarboxylic acid. The aqueous composition is at least substantially free of an antimicrobial agent. The aqueous composition has a viscosity of between 2,000 and 100,000 cps.

Abstract: A probe apparatus includes a plurality of nested sheaths including an inner sheath forming an inner sheath passage and an outer sheath forming an outer sheath passage. A cannula forms an actuator linkage that extends from a proximal linkage end portion to a distal linkage end portion. The actuator linkage extends through the inner sheath passage from the proximal end portion at a main body forming a handle portion to the distal linkage end portion and forms a lumen therethrough. A blade is in connection with the distal linkage end portion and the inner sheath. An imaging apparatus includes an imager extending through the cannula at the distal linkage end portion and captures image data in a field of view.

Abstract: An archery bow sling can include one or more cam covers that can cover respective cams of an archery bow, a base panel, an arrowhead hood extending away from a cam cover adjacent the base panel, an arrow retainer between the hood and another cam cover, the arrow retainer defining slots configured to receive one or more arrows; and a sling strap joined with the cam covers on opposing ends of the sling. The sling can be selectively removable from the archery bow with the arrows being carried by the sling and separate from the archery bow, which can itself be quiver-less. The sling can include a fletching guard distal from the hood and configured to extend over fletchings on the arrows, and a string cover panel that provides a string compartment configured to receive and/or protect a bowstring of the bow. A related method of use is provided.

Abstract: Provided are methods and materials for assaying known and candidate therapeutics for inotropic cardiac effects in one or more in vitro assay formats comprising preloaded cardiac tissues and/or organoids.

Abstract: At least some embodiments of the technology are directed to an automated slide processing apparatus configured to apply at least one reagent to a specimen carried by a microscope slide. The slide processing station can include a support element with a support surface, at least one vacuum port, and a sealing member having a non-round shape. In an uncompressed state, the sealing member can extend upwardly beyond the support surface. In a compressed state, the sealing member can be configured to maintain an airtight seal with a backside of the microscope slide as the microscope slide is pulled against the support surface by a vacuum drawn via the at least one vacuum port.

Abstract: A system, including method and apparatus, for generating droplets suitable for droplet-based assays. The disclosed systems may include either one-piece or multi-piece droplet generation components configured to form sample-containing droplets by merging aqueous, sample-containing fluid with a background emulsion fluid such as oil, to form an emulsion of sample-containing droplets suspended in the background fluid. In some cases, the disclosed systems may include channels or other suitable mechanisms configured to transport the sample-containing droplets to an outlet region, so that subsequent assay steps may be performed.

Abstract: Electronic devices may be provided having internal components mounted to a structural glass support member. The structural glass support member may have a planar front surface that forms a front surface of the device. The structural glass support member may have bent portions that form sidewall surfaces of the device. Portions of the structural glass support member may form a transparent display cover layer. A rigid or flexible display may be mounted to the structural glass support member. Additional internal device components may be mounted to the display. A thin enclosure for enclosing the internal components in the device may be mounted to the structural glass support member. The thin enclosure may be mounted to the structural glass support member using a peripheral member. The thin enclosure may be free from attachments to internal components or may be adhesively bonded to one or more internal components.

Abstract: A system for screening compounds for therapeutic cardiac effects in the cells, tissues and organoids (1) of patients having diseases such as neurological diseases or disorders with significant cardiac comorbidities. The system comprises a medical device apparatus that can be suitable for a single-tier screen for cardio-active compounds that comprises a human ventricular cardiac anisotropic sheet (hvCAS) and human ventricular cardiac tissue strip (hvCTS), a two-tier system further comprising human ventricular cardiac organoid chamber (hvCOC) (20), or a three-tier system still further comprising a medical device comprising multiple organoids (20), which include tissues or organoids (1) of the same or different type (e.g., heart, liver, pancreas, kidney).

Abstract: The methods disclosed herein of generating three-dimensional lattice structures and reducing stress shielding have applications including use in medical implants. One method of generating a three-dimensional lattice structure can be used to generate a structure lattice and/or a lattice scaffold to support bone or tissue growth. One method of reducing stress shielding includes generating a structural lattice to provide sole mechanical spacing across an area for desired bone or tissue growth. Some examples can use a repeating modified rhombic dodecahedron or radial dodeca-rhombus unit cell. Some methods are also capable of providing a lattice structure with anisotropic properties to better suit the lattice for its intended purpose.

Abstract: The present disclosure provides methods and compositions for detecting polynucleotides in a sample and for quantifying polynucleotide load in a sample. The polynucleotides can be associated with a disease, disorder, or condition. In some applications, methylated DNA is quantified, e.g., in order to determine the load of polynucleotides in a sample. The present disclosure also provides methods and compositions for determining the load of fetal polynucleotides in a biological sample, e.g., the load of fetal polynucleotides (e.g., DNA, RNA) in maternal plasma. The present disclosure provides methods and compositions for detecting cellular processes such as cellular viability, growth rates, and infection rates. This disclosure also provides compositions and methods for detecting differences in copy number of a target polynucleotide. In some embodiments, the methods and compositions provided herein are useful for diagnosis of fetal genetic abnormalities, when the starting sample is maternal tissue (e.g.

Abstract: Computer systems and software methods can be configured to automatically correlate novice actor preferences of subject matter items (e.g., goods and services) and provider data across multiple platforms, guided by item displayers. The displayers can use novice actor preferences, available items with third-party evaluations, and generative Artificial Intelligence (AI) to guide toward stated goals. The system can automatically generate a list of items, associated with displayer-provided workflow steps, to be matched with preferences. These items can be listed in order based on the AI-determined probability of each meeting novice actor goals. Providers who interact with the system operator can ensure that their goods and services are included within the system.

Abstract: The present disclosure relates generally to chemical indicators. In particular, the chemical indicators are useful for monitoring sterilization processes. The chemical indicator includes a fluid pathway and a chamber comprises a chemical-indicating composition.

Abstract: Disclosed herein are embodiments of an Al—Ce—Cu alloy for use in additive manufacturing. The disclosed alloy embodiments provide fabricated objects, such as bulk components, comprising a heterogeneous microstructure and having good mechanical properties even when exposed to conditions used during the additive manufacturing process. Methods for making and using alloy embodiments also are disclosed herein.

Abstract: Oligonucleotide primers and methods of use in producing sequencing libraries are provided according to aspects of the present disclosure which include, from 5? to 3?, a homopolymer-hybridizing region, and an anchor region comprising 5?-(?)nNm-3?, wherein the homopolymer-hybridizing region is a contiguous sequence of 5 to 20 elements, wherein the elements are nucleotides or Tm increasing nucleotide analogs, wherein at least 4 of the elements are Tm increasing nucleotide analogs, wherein the homopolymer-hybridizing region hybridizes to a complementary homopolymer tract of a target nucleic acid, wherein the complementary homopolymer tract comprises a contiguous sequence of complementary elements, wherein X is any nucleotide or nucleotide analog with the proviso that ? is not a nucleotide or nucleotide analog complementary to a complementary element of the complementary homopolymer tract, and wherein N is any nucleotide or nucleotide analog.

Abstract: A method for preparing core/shell particles includes forming a suspension of ethylenically unsaturated monomer droplets containing one or more monomers and a porogen in an aqueous medium containing a first stabilizer and a polymerization initiator, wherein at least one of the monomers is a cross-linking monomer, and wherein the first stabilizer is an inorganic colloid. The method further includes polymerizing the one or more monomers to form core/shell particles having a core of a porous polymer and a polymeric shell having a shell thickness of at least 5 nm, wherein any pores in the polymeric shell have a diameter of less than 2 nm.

Abstract: This relates generally to intelligent automated assistants and, more specifically, to provide a handsfree notification management system. An example method includes displaying one or more notifications by the electronic device. In response to displaying the one or more notifications, the method includes detecting a visual interaction of a user with the one or more notifications, identifying a notification from the one or more notifications based on the visual interaction, receiving a speech input related to the notification from the user, determining one or more actions associated with the notification based on the speech input, and performing the one or more actions.

Abstract: Presented here are methods for producing a recombinant anti-TNF antibody having a heavy chain (HC) comprising SEQ ID NO:38 and a light chain (LC) comprising SEQ ID NO:37 and compositions comprising the recombinant anti-TNF antibody.

Abstract: Methods and systems described in this disclosure electronically notarize a document. The system can receive biometric information from a user, extract characteristics from the biometric information, and compare the characteristics of the biometric information with previously stored characteristics of the user's biometric information. When the characteristics of the biometric information match the previously stored characteristics to a threshold, the system can create an identity of the user using the characteristics of the biometric information. The system can send a document to the user for cryptographic signature and receive an indication that the document has been signed. The cryptographic signature can be generated with a digest of the document, the identity, and a cryptographic key associated with the user. The system can inspect the digest of the document, the cryptographic key, and the identity associated with the document to verify authenticity of the document and the identity of the user.

Abstract: A cartridge for use with a surgical instrument includes a curved body and a deck defined by the curved body and configured to clamp tissue against an anvil. A plurality of staple openings is formed in the deck and is configured to house a plurality of staples. An arcuate slot is formed in the deck and is configured to slidably receive a cutting member therethrough. The deck includes a sloped deck portion that slopes away from the arcuate slot in a direction transverse to a length of the arcuate slot. The sloped deck portion is configured to provide varied compression of tissue across a width of the deck.