Patents by Inventor Kevin D. Belfield
Kevin D. Belfield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8232303Abstract: Disclosed are fluorescent compounds useful as intracellular pH probes. In particular, the invention teaches a two-photon absorbing, water soluble, fluorescent compound, a fluorene derivative, which is effective as a near-neutral pH indicator and particularly as an intracellular probe. A method for chemical synthesis of the claimed compounds is provided.Type: GrantFiled: July 7, 2008Date of Patent: July 31, 2012Assignee: University of Central Florida Research Foundation, Inc.Inventors: Kevin D. Belfield, Sheng Yao
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Patent number: 8192590Abstract: Efficient method for preparing sulfonium photoacid generators (PAGs) by microwave-assisted reaction of diarylsufides in the presence of alkylaryliodonium salts. Microwave-assisted synthesis of the PAGs is significantly faster, reducing reaction time with less energy consumption. Reaction times using the microwave-assisted synthesis are in a range of from 90 to 420 faster than conventional thermal conditions. The photoacid quantum yields of several salts prepared by the microwave reaction were measured; the photoacid quantum yields of new sulfonium PAGs were in a range from 0.01 to 0.4 times greater than yields from conventional synthesis. Incorporating a nitro group in the structures of the sulfonium salts increased photoacid quantum yield, induced intersystem crossing and increased the efficiency of photoacid generation compounds.Type: GrantFiled: April 13, 2009Date of Patent: June 5, 2012Assignee: University of Central Florida Research Foundation, Inc.Inventors: Kevin D. Belfield, Ciceron O. Yanez
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Patent number: 7964333Abstract: An optical data storage system and method with non-destructive multiple readout of 3-D data stored in multiple layers uses two-photon induced fluorescence modulation. The novel system uses the photochromic properties of the open and closed form of diarylethene in the two-photon energy transfer-based read-out method of a 3-D optical data storage system, providing more than 10,000 readout cycles without significantly compromising the stored data. The system of the present invention can be recorded and read out using the same wavelength simply by changing the intensities. Also, since the incident intensity used in two-photon readout is low due to the efficient absorption of the two-photon absorbing fluorene dye, a less expensive, nanosecond laser diode can be used, making this two-photon 3-D data storage system less expensive, stable, highly responsive, and reliable. This photochromic system is capable of either write-once read many (WORM) or erasable and rewritable 3D optical data storage.Type: GrantFiled: June 6, 2007Date of Patent: June 21, 2011Assignee: University of Central Florida Research Foundation, Inc.Inventor: Kevin D Belfield
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Patent number: 7611823Abstract: Image formation via photoinduced fluorescence changes in a polymeric medium with two-photon fluorescence readout of a multi-layer structure. Fluorophore-containing polymers, possessing one or more basic functional groups, underwent protonation in the presence of a photoinduced acid generator upon exposure to a broad-band UV light source or fast-pulsed red to near-IR laser irradiation. Solution studies demonstrated formation of monoprotonated and diprotonated species upon irradiation, each resulting in distinctly different absorption and fluorescence properties. The fluorescence of the original, neutral, fluorophore was reduced upon monoprotonation leading to a concomitant increase in fluorescence at longer wavelengths due to the monoprotonated form, the basis for multichannel data readout.Type: GrantFiled: November 10, 2005Date of Patent: November 3, 2009Assignee: University of Central Florida Research Foundation, Inc.Inventor: Kevin D. Belfield
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Patent number: 7608384Abstract: Ternary optical data storage method and apparatus for Write Once Read Many Times (WORM) optical data storage with two-photon fluorescent writing and readout. The data storage capacity is limited by the optical resolution of a system. In CD/DVD systems, an increase in the aerial data density has been primarily achieved by decreasing the bit dimension. However, the size of the optical spot (bit) is restricted by limitations imposed by the diffraction of light (Rayleigh criterion). Therefore, technologies that can effectively create and detect spot sizes beyond the diffraction limit (sub-Rayleigh) hold promise to achieving high-density optical storage.Type: GrantFiled: April 9, 2004Date of Patent: October 27, 2009Assignee: University of Central Florida Research Foundation, Inc.Inventor: Kevin D Belfield
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Patent number: 7598018Abstract: Image formation via photoinduced fluorescence changes in a polymeric medium with two-photon fluorescence readout of a multi-layer structure. Fluorophore-containing polymers, possessing one or more basic functional groups, underwent protonation in the presence of a photoinduced acid generator upon exposure to a broad-band UV light source or fast-pulsed red to near-IR laser irradiation. Solution studies demonstrated formation of monoprotonated and diprotonated species upon irradiation, each resulting in distinctly different absorption and fluorescence properties. The fluorescence of the original, neutral, fluorophore was reduced upon monoprotonation, leading to a concomitant increase in fluorescence at longer wavelengths due to the monoprotonated form, the basis for multichannel data readout.Type: GrantFiled: February 16, 2007Date of Patent: October 6, 2009Assignee: University of Central Florida Research Foundation, Inc.Inventor: Kevin D. Belfield
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Patent number: 7524611Abstract: Image formation via photoinduced fluorescence changes in a polymeric medium with two-photon fluorescence readout of a multi-layer structure. Fluorophore-containing polymers, possessing one or more basic functional groups, underwent protonation in the presence of a photoinduced acid generator upon exposure to a broad-band UV light source or fast-pulsed red to near-IR laser irradiation. Solution studies demonstrated formation of monoprotonated and diprotonated species upon irradiation, each resulting in distinctly different absorption and fluorescence properties. The fluorescence of the original, neutral, fluorophore was reduced upon monoprotonation, leading to a concomitant increase in fluorescence at longer wavelengths due to the monoprotonated form, the basis for multichannel data readout.Type: GrantFiled: September 26, 2007Date of Patent: April 28, 2009Assignee: University of Central Florida Research Foundation, Inc.Inventor: Kevin D. Belfield
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Publication number: 20080187862Abstract: Image formation via photoinduced fluorescence changes in a polymeric medium with two-photon fluorescence readout of a multi-layer structure. Fluorophore-containing polymers, possessing one or more basic functional groups, underwent protonation in the presence of a photoinduced acid generator upon exposure to a broad-band UV light source or fast-pulsed red to near-IR laser irradiation. Solution studies demonstrated formation of monoprotonated and diprotonated species upon irradiation, each resulting in distinctly different absorption and fluorescence properties. The fluorescence of the original, neutral, fluorophore was reduced upon monoprotonation, leading to a concomitant increase in fluorescence at longer wavelengths due to the monoprotonated form, the basis for multichannel data readout.Type: ApplicationFiled: September 26, 2007Publication date: August 7, 2008Inventor: Kevin D. Belfield
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Patent number: 7291442Abstract: Image formation via photoinduced fluorescence changes in a polymeric medium with two-photon fluorescence readout of a multi-layer structure. Fluorophore-containing polymers, possessing one or more basic functional groups, underwent protonation in the presence of a photoinduced acid generator upon exposure to a broad-band UV light source or fast-pulsed red to near-IR laser irradiation. Solution studies demonstrated formation of monoprotonated and diprotonated species upon irradiation, each resulting in distinctly different absorption and fluorescence properties. The fluorescence of the original, neutral, fluorophore was reduced upon monoprotonation, leading to a concomitant increase in fluorescence at longer wavelengths due to the monoprotonated form, the basis for multichannel data readout.Type: GrantFiled: October 21, 2005Date of Patent: November 6, 2007Assignee: University of Central Florida Research Foundation, Inc.Inventor: Kevin D. Belfield
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Patent number: 7282514Abstract: Fluorescent dyes and probes are key components in multiphoton based fluorescence microscopy imaging of biological samples. In order to address the demand for better performing dyes for two-photon based imaging, a new series of reactive fluorophores tailored for multiphoton imaging has been disclosed. These fluorophores are based upon the fluorene ring system, known to exhibit high fluorescence quantum yields, typically >0.7, and possess high photostability. They have been functionalized with moieties to act, e.g., as efficient amine-reactive fluorescent probes for the covalent attachment onto, e.g., proteins and antibodies. The synthesis and the single-photon spectral characteristics, as well as measured two-photon absorption cross sections of the reactive fluorophores in solution are presented. Spectral characterizations of bovine serum albumin (BSA) conjugated with the new reactive probe is presented.Type: GrantFiled: April 11, 2007Date of Patent: October 16, 2007Assignee: Research Foundation of The University of Central Florida, Inc.Inventors: Kevin D. Belfield, Katherine J. Schafer
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Patent number: 7253287Abstract: Fluorescent dyes and probes are key components in multiphoton based fluorescence microscopy imaging of biological samples. In order to address the demand for better performing dyes for two-photon based imaging, a new series of reactive fluorophores tailored for multiphoton imaging has been disclosed. These fluorophores are based upon the fluorene ring system, known to exhibit high fluorescence quantum yields, typically >0.7, and possess high photostability. They have been functionalized with moieties to act, e.g., as efficient amine-reactive fluorescent probes for the covalent attachment onto, e.g., proteins and antibodies. The synthesis and the single-photon spectral characteristics, as well as measured two-photon absorption cross sections of the reactive fluorophores in solution are presented. Spectral characterizations of bovine serum albumin (BSA) conjugated with the new reactive probe is presented.Type: GrantFiled: May 13, 2005Date of Patent: August 7, 2007Assignee: Research Foundation of The University of Central Florida, Inc.Inventors: Kevin D. Belfield, Katherine J. Schafer
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Patent number: 7001708Abstract: Image formation via photoinduced fluorescence changes in a polymeric medium with two-photon fluorescence readout of a multi-layer structure. Fluorophore-containing polymers, possessing one or more basic functional groups, underwent protonation in the presence of a photoinduced acid generator upon exposure to a broad-band UV light source or fast-pulsed red to near-IR laser irradiation. Solution studies demonstrated formation of monoprotonated and diprotonated species upon irradiation, each resulting in distinctly different absorption and fluorescence properties. The fluorescence of the original, neutral, fluorophore was reduced upon monoprotonation, leading to a concomitant increase in fluorescence at longer wavelengths due to the monoprotonated form, the basis for multichannel data readout.Type: GrantFiled: November 27, 2002Date of Patent: February 21, 2006Assignee: University of Central Florida Research Foundation, Inc.Inventor: Kevin D. Belfield
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Patent number: RE42076Abstract: A two and three dimensional display medium having a novel transparent polymer composite containing particles of crystals doped with Yb3+ and other rare earth ions. The polymer composite creates homogeneously dispersed compositions without cracking or delamination of the film and can be used for various optical applications.Type: GrantFiled: January 18, 2007Date of Patent: January 25, 2011Assignee: University of Central Florida Research Foundation, Inc.Inventors: Michael Bass, Kevin D. Belfield