Abstract: The present invention provides methods for the treatment of non-alcoholic steatohepatitis (NASH) including advanced fibrotic and/or cirrhotic stages of NASH. The methods include administration of a compound comprising a double stranded RNAi (dsRNAi) oligonucleotide, or a pharmaceutically acceptable salt thereof, to the patient. The dsRNAi oligonucleotide optionally contains an antisense strand and a sense strand, wherein the antisense strand and the sense strand form a duplex region, and wherein the antisense strand comprises a region of complementarity to a KHK mRNA target sequence.

Abstract: dsRNAi oligonucleotides can be used in methods for the treatment of NASH, preferably the advanced fibrotic and/or cirrhotic stages thereof, using dosage regimens comprising a loading phase followed by a maintenance phase.

Abstract: A touch sensor device (TSD) includes TSD electrodes associated with a surface of the TSD. Also, an overlay that includes marker electrode(s) is also associated with at least a portion of the surface of the TSD. The TSD also includes drive-sense circuits (DSCs) operably coupled to the plurality of TSD electrodes. A DSC is configured to provide a TSD electrode signal to a TSD electrode and simultaneously to sense a change of the TSD electrode signal based on a change of impedance of the TSD electrode caused by capacitive coupling between the TSD electrode and the marker electrode(s) of the overlay. Processing module(s) is configured to process a digital signal generated by the DSC to determine characteristic(s) of the overlay that is associated with the at least a portion of the surface of the TSD.

Abstract: Mechanisms are provided to receive encoded header information stored on a tape of a tape drive, wherein the encoded header information has been generated by: generating, for a plurality of tracks of the tape of the tape drive, a header information in a plurality of symbols, wherein the plurality of symbols is comprised of a first set of symbols and a second set of symbols, wherein the first set of symbols include identical information across all tracks of the plurality of tracks, and wherein the second set of symbols are configurable to include different information across all tracks of the plurality of tracks; and modifying, for writing to the tape of the tape drive, the first set of symbols of the plurality of tracks to include parity information corresponding to information included in the second set of symbols of the plurality of tracks. The received encoded header information is decoded.

Abstract: An e-pen includes e-pen sensor electrodes (including a first and a second e-pen sensor electrode) and drive-sense circuits (DSCs) (including a first DSC and a second DSC. The first DSC drives a first e-pen signal having a first frequency via a first single line coupling to the first e-pen sensor electrode and simultaneously senses, via the first single line, the first e-pen signal. Based on e-pen/touch sensor device interaction, the first e-pen signal is coupled into at least one touch sensor electrode of the touch sensor device. The first DSC process the first e-pen signal to generate a first digital signal representative of a first electrical characteristic of the first e-pen sensor electrode. Similarly, the second DSC drives a second e-pen signal having a second frequency via a second single line coupling to the second e-pen sensor electrode and simultaneously senses, via the second single line, the second e-pen signal.

Abstract: A touch sensor device (TSD) includes TSD electrodes associated with a surface of the TSD. Also, an overlay that includes marker electrode(s) is also associated with a region of the surface of the TSD. The TSD also includes drive-sense circuits (DSCs) operably coupled to the plurality of TSD electrodes. A DSC is configured to provide a TSD electrode signal to a TSD electrode and simultaneously to sense a change of the TSD electrode signal based on a change of impedance of the TSD electrode caused by capacitive coupling between the TSD electrode and the marker electrode(s) of the overlay. Processing module(s) is configured to process a digital signal generated by the DSC and other digital signals generated by other DSCs determine the region of the surface of the TSD that is associated with the overlay and to adapt sensitivity of the TSD within that region.

Abstract: Provided are a method, system, and computer program product in which mechanisms are provided to generate, for a plurality of tracks of a tape of a tape drive, a header information in a plurality of symbols, wherein the plurality of symbols is comprised of a first set of symbols and a second set of symbols, wherein the first set of symbols include identical information across all tracks of the plurality of tracks, and wherein the second set of symbols are configurable to include different information across all tracks of the plurality of track. A modification is made, for writing to the tape of the tape drive, of the first set of symbols of the plurality of tracks to include parity information corresponding to information included in the second set of symbols of the plurality of tracks.

Abstract: Mechanisms are provided to receive encoded header information stored on a tape of a tape drive, wherein the encoded header information has been generated by: generating, for a plurality of tracks of the tape of the tape drive, a header information in a plurality of symbols, wherein the plurality of symbols is comprised of a first set of symbols and a second set of symbols, wherein the first set of symbols include identical information across all tracks of the plurality of tracks, and wherein the second set of symbols are configurable to include different information across all tracks of the plurality of tracks; and modifying, for writing to the tape of the tape drive, the first set of symbols of the plurality of tracks to include parity information corresponding to information included in the second set of symbols of the plurality of tracks. The received encoded header information is decoded.

Abstract: This disclosure provides systems, devices, apparatus, and methods, including computer programs encoded on storage media, for a high-performance and low-latency implementation of a wavelet-based image compression scheme. A processor may generate, in a single pass for each of a plurality of horizontal and vertical divisions of an image frame, a set of wavelet coefficients for the image frame based on a DWT. The processor may select a set of bits associated with the set of wavelet coefficients to remove based on an entropy coding process. The processor may serialize the set of wavelet coefficients, where the set of serialized wavelet coefficients do not include the set of bits. The processor may output, for a second device, a bitstream including the set of serialized wavelet coefficients.

Abstract: A coating for vehicle components, such as frame assemblies and cradle assemblies formed of steel, is provided. The coating includes a first layer including a high phosphate composition applied to the substrate, and a second layer including wax applied to the first layer. For example, the first layer can include a first inorganic acid, an inorganic salt, a second inorganic acid, nickel salt, and ammonium bifluoride; and the second layer can include petroleum, carbon black pigment, and a corrosion inhibitor, the corrosion inhibitor including magnesium. The coating has been found to improve corrosion resistance when applied to steel substrates, compared to wax coatings which are currently applied to steel substrates.

Abstract: The present invention is directed to a method of increasing almond nutmeat yield comprising applying aminoethoxyvinylglycine (AVG) or a salt of AVG at an effective rate to an almond tree following full bloom.

Abstract: Aspects relate to an autonomous ground working vehicle. The vehicle has a chassis, wheels coupled to the chassis, a motor housing coupled to the chassis, a tool motor, and a tool. The motor housing defines a motor cavity extending in an axial direction and has a first inner housing portion having a first helical thread about the motor cavity and a second inner housing portion having a second helical thread about the motor cavity that engages the first helical thread. The first inner housing portion has a motor mounting surface and is axially translatable relative to the chassis and rotatably fixed relative to the chassis. The second inner housing portion is rotatable relative to the chassis and axially fixed relative to the chassis. The tool motor is fixed to the motor mounting surface and has an output shaft extending in a first direction. The tool is fixed to the output shaft.

Abstract: The present invention provides novel intermediates and processes useful in the manufacture of tirzepatide, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention is directed to a method of increasing almond nutmeat yield comprising applying aminoethoxyvinylglycine (AVG) or a salt thereof at an effective rate to an almond tree following full bloom.

Abstract: A handle assembly for an autonomous vehicle such as a lawn mower is provided and may include a cradle adapted to receive a mobile computer. The mobile computer may communicate with a controller carried by the mower. The handle assembly may be configured in both an autonomous mode position and a manual mode position. The vehicle may operate autonomously when the handle assembly is in the autonomous mode position, and be adapted to move under manual operator control, e.g., for perimeter training, when the handle assembly is in the manual mode position. Methods for training the mower and apparatus for storing the mower are also provided.

Abstract: Mechanisms for providing enhanced system performance and reliability on multi-core computing devices are discussed. Embodiments use modified hardware and/or software so that when a System Management Interrupt (SMI #) is generated, only a single targeted CPU core enters System Management Mode (SMM) in response to the SMI while the remaining CPU cores continue operating in normal mode. Further, a multi-threaded SMM environment and mutual exclusion objects (mutexes) may allow guarding of key hardware resources and software data structures to enable individual CPU cores among the remaining CPU cores to subsequently also enter SMM in response to a different SMI while the originally selected CPU core is still in SMM.

Abstract: A coating for vehicle components, such as frame assemblies and cradle assemblies formed of steel, is provided. The coating includes a first layer including a high phosphate composition applied to the substrate, and a second layer including wax applied to the first layer. For example, the first layer can include a first inorganic acid, an inorganic salt, a second inorganic acid, nickel salt, and ammonium bifluoride; and the second layer can include petroleum, carbon black pigment, and a corrosion inhibitor, the corrosion inhibitor including magnesium. The coating has been found to improve corrosion resistance when applied to steel substrates, compared to wax coatings which are currently applied to steel substrates.

Abstract: A methodology that enables, for example, tape drive operation at lower SNR and/or reduced rewrite area uses a first threshold T and a second threshold r for a rewrite condition. Codeword interleaves (CWIs) in a data set are written onto a plurality of simultaneously-written parallel tracks of a magnetic recording medium, read back and error correction decoded. A determination is made as to whether at least one of the C1 or C1? codewords in each decoded CWI contains more byte errors than the second threshold r of the rewrite condition. A number of CWIs in a rewrite buffer are according to the following criteria: bi?=bi?T when bi is greater than the first threshold T, and bi?=0 when bi is less than or equal to the first threshold T.

Abstract: A part, such as an automotive part, is provided. The part includes at least two work pieces of steel which are joined together at a weld seam which includes at least one of nickel and iron and is substantially entirely free of silicate islands. The part also includes a painted, phosphated or electrocoated coating which is bonded with at least a portion of the substantially entirely silicate island free weld seam.

Abstract: A part, such as an automotive part, is provided. The part includes at least two work pieces which are joined together at a weld seam. The weld seam has a laser metal deposition layer with at least one of nickel and iron, and the laser metal deposition layer is substantially entirely free of silicate islands. The part further includes a painted, phosphate or electrocoated coating which is bonded with at least a portion of the laser metal deposition layer of the weld seam.