Abstract: A device is for estimating the central blood pressure of a subject. The device comprises a sensor patch comprising an array of sensors configured to measure an indication of the blood pressure of a peripheral blood vessel and perform ultrasound imaging of the peripheral blood vessel. The device also comprises a processor configured to obtain a peripheral pressure signal comprising a pressure waveform from the indication of the blood pressure from the sensor patch and derive an image of the peripheral blood vessel from the signals received from the sensor patch. A vessel diameter is determined from the image of the peripheral blood vessel over time comprising a vessel diameter waveform and an estimate of the central blood pressure of the subject is derived from the pressure waveform and/or the vessel diameter waveform.

Abstract: The invention provides a system for determining a real-time valve function of a subject. The system comprises a processing unit adapted to: obtain a numerical model of a cardiac system, the numerical model being a 0D numerical model or a 1D numerical model, wherein the numerical model is adapted to receive physiological data as an input and output a simulated function of the cardiac system in real-time, wherein the simulated function of the cardiac system comprises a simulated function of a valve within the cardiac system. The processor is further adapted to obtain a continuous stream of physiological data from the subject; provide the continuous stream of physiological data as an input to the numerical model of the cardiac system, thereby generating a simulated real-time function of the cardiac system of the subject; and determine a real-time valve function of the subject based on the simulated real-time function of the cardiac system of the subject.

Abstract: The invention provides a method for calculating an end-diastolic pressure-volume relationship. The method includes obtaining a cardiac input representing a region of interest, wherein the region of interest comprises a left ventricle and a left atrium of a subject. An end of diastasis volume of the left ventricle is then determined based on the cardiac input, wherein diastasis is a stage of diastole during a heart cycle before atrial contraction. Further, an end of diastasis pressure in the left atrium is determined based on the cardiac input and a linearized ventricular pressure-volume relationship is generated based on the end of diastasis volume of the left ventricle and the end of diastasis pressure in the left atrium. An end-diastolic pressure-volume relationship is then determined based on an end-diastolic volume of the left ventricle and the linearized ventricular pressure-volume relationship.

Abstract: The invention provides a method for obtaining a physiological measure from a subject, in particular a P-V loop. The method includes obtaining a numerical model of a cardiac system and obtaining, in a non-invasive manner, physiological data from the subject. The numerical model is then updated based on the physiological data. The physiological data is then provided to the updated numerical model and a physiological measure is derived based on an output of the updated numerical model, wherein the physiological measure includes a P-V loop.