Patents by Inventor Kevin Dinnell

Kevin Dinnell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indole Derivative Modulators of the alpha 7 nAChR
    Publication number: 20150038517
    Abstract: This invention relates to modulation of the ?7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a salt thereof: wherein R1 is imidazolyl, pyridinyl or pyrimidinyl, any of which is optionally substituted by one group independently selected from C1-3alkyl and C1-3alkoxy.
    Type: Application
    Filed: August 7, 2014
    Publication date: February 5, 2015
    Inventor: Kevin Dinnell
  • Indole and azaindole modulators of the alpha 7 nAChR
    Publication number: 20150005321
    Abstract: This invention relates to modulation of the ?7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I): or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 4, 2014
    Publication date: January 1, 2015
    Inventors: Kevin Dinnell, Andrew Lightfoot, Gillian Elizabeth Lunniss
  • Indole derivative modulators of the alpha 7 nAChR
    Patent number: 8829031
    Abstract: This invention relates to modulation of the ?7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a salt thereof: wherein R1 is imidazolyl, pyridinyl or pyrimidinyl, any of which is optionally substituted by one group independently selected from C1-3alkyl and C1-3alkoxy.
    Type: Grant
    Filed: April 14, 2010
    Date of Patent: September 9, 2014
    Assignee: Proximagen Ltd.
    Inventor: Kevin Dinnell
  • Indole and azaindole modulators of the alpha 7 nachr
    Patent number: 8796283
    Abstract: This invention relates to modulation of the ?7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I): or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: August 5, 2014
    Assignee: Proximagen Limited
    Inventors: Kevin Dinnell, Andrew Lightfoot, Gillian Elizabeth Lunniss
  • Indoles as modulators of nicotinic acetylcholine receptor subtype alpha-7
    Patent number: 8377941
    Abstract: The present invention relates to modulation of the ?7 nicotinic acetylcholine receptor (nAChR) by a compound of List A or a salt thereof, which may be represented, but is not limited to the compound N-[(2-Trifluoromethyl-1H-indol-5-yl)methyl]-2-(trifluoromethyl)-5-pyrimidinecarboxamide.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: February 19, 2013
    Assignee: Proximagen Limited
    Inventors: Kevin Dinnell, Andrew P Lightfoot, Howard Robert Marshall
  • INDOLE AND AZAINDOLE MODULATORS OF THE ALPHA 7 NACHR
    Publication number: 20120283273
    Abstract: This invention relates to modulation of the ?7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 14, 2010
    Publication date: November 8, 2012
    Applicant: PROXIMAGEN LIMITED
    Inventors: Kevin Dinnell, Andrew Lightfoot, Gillian Elizabeth Lunniss
  • Indole modulators of the alpha 7 nicotinic acetylcholine receptor
    Patent number: 8283365
    Abstract: This invention relates to modulation of the ?7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a salt thereof
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: October 9, 2012
    Assignee: Proximagen Limited
    Inventors: Kevin Dinnell, Andrew P Lightfoot, Howard Robert Marshall
  • INDOLE DERIVATIVE MODULATORS OF THE ALPHA 7 NACHR
    Publication number: 20120136009
    Abstract: This invention relates to modulation of the ?7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a salt thereof: wherein R1 is imidazolyl, pyridinyl or pyrimidinyl, any of which is optionally substituted by one group independently selected from C1-3alkyl and C1-3alkoxy.
    Type: Application
    Filed: April 14, 2010
    Publication date: May 31, 2012
    Inventor: Kevin Dinnell
  • INDOLE MODULATORS OF THE ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR
    Publication number: 20110034515
    Abstract: This invention relates to modulation of the ?7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a salt thereof
    Type: Application
    Filed: April 16, 2009
    Publication date: February 10, 2011
    Inventors: Kevin Dinnell, Andrew P. Lightfoot, Howard Robert Marshall
  • INDOLES AS MODULATORS OF NICOTICIC ACETYLCHOLINE RECEPTOR SUBTYPE ALPHA-7
    Publication number: 20110028486
    Abstract: The present invention relates to modulation of the ?7 nicotinic acetylcholine receptor (nAChR) by a compound of List A or a salt thereof, which may be represented, but is not limited to the compound N-[(2-Trifluoromethyl-1H-indol-5-yl)methyl]-5-(trifluoromethyl)-2-pyrimidinecarboxamide.
    Type: Application
    Filed: April 16, 2009
    Publication date: February 3, 2011
    Inventors: Kevin Dinnell, Andrew P. Lightfoot, Howard Robert Marshall
  • Sulphones which modulate the action of gamma-secretase
    Patent number: 7598386
    Abstract: Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of ?-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: October 6, 2009
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Jose Luis Castro Pineiro, Ian Churcher, Kevin Dinnell, Timothy Harrison, Sonia Kerrad, Alan John Nadin, Paul Joseph Oakley, Andrew Pate Owens, Duncan Edward Shaw, Martin Richard Teall, Susannah William, Brian John Williams
  • Sulphones which modulate the action of gamma secretase
    Patent number: 7595344
    Abstract: Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: May 6, 2008
    Date of Patent: September 29, 2009
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Jose Luis Castro Pineiro, Ian Churcher, Kevin Dinnell, Timothy Harrison, Sonia Kerrad, Alan John Nadin, Paul Joseph Oakley, Andrew Pate Owens, Duncan Edward Shaw, Martin Richard Teall, Susannah William, Brian John Williams
  • Sulphones which modulate the action of gamma secretase
    Publication number: 20090131419
    Abstract: Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: May 6, 2008
    Publication date: May 21, 2009
    Inventors: Jose Luis Castro Pineiro, Ian Churcher, Kevin Dinnell, Timothy Harrison, Sonia Kerrad, Alan John Nadin, Paul Joseph Oakley, Andrew Pate Owens, Duncan Edward Shaw, Martin Richard Teall, Susannah William, Brian John Williams
  • Cyclohexyl sulphones as gamma-secretase inhibitors
    Patent number: 7410964
    Abstract: Compounds of formula I: inhibit gamma-secretase and hence find use in treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: August 12, 2008
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Kevin Dinnell, Karl Richard Gibson, Timothy Harrison, Richard Alexander Jelley, Alan John Nadin, Paul Joseph Oakley, Andrew Pate Owens, Duncan Edward Shaw, Brian John Williams
  • Cyclic sulfonamides for inhibition of gamma-secretase
    Patent number: 7342009
    Abstract: Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: March 11, 2008
    Assignee: Merck & Co., Inc.
    Inventors: Kevin Dinnell, Timothy Harrison, Alan John Nadin, Andrew Pate Owens, Duncan Edward Shaw, Brian John Williams
  • Cyclic sulfonamides for inhibition of gamma-secretase
    Publication number: 20080045515
    Abstract: Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: August 1, 2007
    Publication date: February 21, 2008
    Inventors: Kevin Dinnell, Timothy Harrison, Alan Nadin, Andrew Owens, Duncan Shaw, Brian Williams
  • Novel cyclohexyl sulphones
    Publication number: 20080045533
    Abstract: Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: October 18, 2007
    Publication date: February 21, 2008
    Inventors: Ian Churcher, Kevin Dinnell, Timothy Harrison, Sonia Kerrad, Alan Nadin, Paul Oakley, Duncan Shaw, Martin Teall, Susannah Williams, Brian Williams
  • Cyclohexyl sulphones
    Patent number: 7304094
    Abstract: Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: December 4, 2007
    Assignee: Merck Sharp + Dohme
    Inventors: Ian Churcher, Kevin Dinnell, Timothy Harrison, Sonia Kerrad, Alan John Nadin, Paul Joseph Oakley, Duncan Edward Shaw, Martin Richard Teall, Susannah Williams, Brian John Williams
  • Sulphones which modulate the action of gammasecretase
    Publication number: 20070213329
    Abstract: Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of ?-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: April 23, 2007
    Publication date: September 13, 2007
    Inventors: Jose Castro Pineiro, Ian Churcher, Kevin Dinnell, Timothy Harrison, Sonia Kerrad, Alan Nadin, Paul Oakley, Andrew Owens, Duncan Shaw, Martin Teall, Susannah Williams, Brian Williams
  • Gem-disubstituted cyclohexane derivatives and their use as therapeutic agents
    Patent number: 7253205
    Abstract: The present invention relates compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 represent a variety of substituents, ring A is a phenyl or pyridyl ring; d is zero, 1 or 2; and pharmaceutically acceptable salts and N-oxides thereof.
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: August 7, 2007
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Jose Luis Castro Pineiro, Kevin Dinnell, Jason Matthew Elliott, Gregory John Hollingworth, Duncan Edward Shaw, Christopher John Swain