Abstract: The present invention relates to dermal vaccine formulations, designed for targeted delivery of an immunogenic composition to a dermal compartment of skin including the intradermal and epidermal compartments. The dermal vaccine formulations of the invention comprise an antigenic or immunogenic agent, and at least one molecule, e.g., a chemical agent, which enhances the presentation and/or availability of the antigenic or immunogenic agent to the immune cells of the intradermal compartment or epidermal compartment resulting in an enhanced immune response. The dermal vaccine formulations of the invention have enhanced efficacy as the antigenic or immunogenic agent is delivered to the intradermal compartment or epidermal compartment with enhanced presentation and/or availability to the immune cells that reside therein.

Abstract: An extended coverage ceiling sprinkler includes a generally tubular body having an inlet open end and an opposing, outlet open end with a minimal internal diameter greater than 0.65 inches and a K-factor of between about 14 and about 15. A plug at least essentially closes the outlet open end and an element releasably retains the plug in the outlet end. A deflector support extends away from the outlet end of the tubular body and a deflector is coupled to the tubular body through the deflector support. The deflector has a major surface facing, spaced from and aligned with the outlet open end with a circular outer perimeter less than 1.7 inches in outer diameter and a central area without water passing openings therethrough at least 0.75 inches in diameter. Slots extend generally radially inwardly from the perimeter and surround the central area which is slotless. The ratio of deflector outer diameter to slot depth is greater than 10 and up to about 14.