Abstract: In some aspects, the disclosure relates methods for treating ventricular tachycardia in a subject. In some embodiments, methods of the disclosure comprise measuring action potential durations and/or expression levels of KCNE3 and/or KCNE4 in a subject. In some aspects, the disclosure relates to methods and compositions for reducing or inhibiting the activity of KCNE3 and/or KCNE4, for example, in subjects having ventricular tachycardia.

Abstract: In some aspects, the disclosure relates methods for identifying ventricular tachycardia in subjects, e.g., subjects who have previously experienced a myocardial infarction. In some embodiments, methods of the disclosure comprise measuring action potential durations and/or expression levels of KCNE3 and/or KCNE4 in a subject. In some aspects, the disclosure relates to methods and compositions for reducing or inhibiting the activity of KCNE3 and/or KCNE4, for example, in subjects having ventricular tachycardia.

Abstract: The systems and methods of the present disclosure provide connectable tiles that can form a self-contained illuminated sign of potentially unlimited size. The self-contained illuminated sign can include one or more tiles. A tile can include a diffusion film having a surface to be illuminated. The tile can include a light guide plate coupled to the diffusion film. The light guide can be configured to evenly distribute light through the diffusion film. The tile can include a solar panel coupled to the light guide. The solar panel can capture light that passes through the diffusion film and the light guide. The tile can include a light source positioned adjacent to the light guide that receives stored electrical power from a battery electrically coupled to the solar panel. The tile can include a connector configured to attach the tile to a second tile.

Abstract: The systems and methods of the present disclosure provide connectable tiles that can form a self-contained illuminated sign of potentially unlimited size. The self-contained illuminated sign can include one or more tiles. A tile can include a diffusion film having a surface to be illuminated. The tile can include a light guide plate coupled to the diffusion film. The light guide can be configured to evenly distribute light through the diffusion film. The tile can include a solar panel coupled to the light guide. The solar panel can capture light that passes through the diffusion film and the light guide. The tile can include a light source positioned adjacent to the light guide that receives stored electrical power from a battery electrically coupled to the solar panel. The tile can include a connector configured to attach the tile to a second tile.

Abstract: The systems and methods of the present disclosure provide connectable tiles that can form a self-contained illuminated sign of potentially unlimited size. The self-contained illuminated sign can include one or more tiles. A tile can include a diffusion film having a surface to be illuminated. The tile can include a light guide plate coupled to the diffusion film. The light guide can be configured to evenly distribute light through the diffusion film. The tile can include a solar panel coupled to the light guide. The solar panel can capture light that passes through the diffusion film and the light guide. The tile can include a light source positioned adjacent to the light guide that receives stored electrical power from a battery electrically coupled to the solar panel. The tile can include a connector configured to attach the tile to a second tile.

Abstract: Light guides for solar-powered signs are disclosed. The light guide can include a sheet of at least partially transparent material configured to transmit light. The light guide can include a plurality of light-extraction features formed on a surface of the sheet. Each light-extraction feature of the plurality of light-extraction features can include a reflective mirror layer deposited on a surface of the light-extraction feature. The solar-powered sign can include the light guide, a diffusion film coupled to the light guide, and a solar panel coupled to the light guide that captures light passing through the diffusion film and the light guide.

Abstract: A method of forming a one-way see-through illumination device including a light guide and a pattern of pixels on a surface of the light guide. The method includes forming pixel wells corresponding to the pixels, via a formation method including photolithography, on the surface of the light guide. The pixels, including a light diffusing layer and a light reflecting layer, are formed using the pixel wells, wherein the pattern of pixels and the light guide are arranged to generate transparent illumination by the frustration of total internal reflection of light injected into the light guide.

Abstract: A device includes a light source and a light guide. The light source is configured to emit photoresist-curative electromagnetic radiation. The light guide is arranged to receive the photoresist-curative electromagnetic radiation from the light source and to guide the received radiation by total internal reflection, the light guide including a pattern of emission points on at least one surface of the light guide, the emission points emitting the photoresist-curative electromagnetic radiation out of the light guide by frustration of total internal reflection caused by the emission points.

Abstract: A device (100) includes a light source (130) and a light guide (110). The light source (130) is configured to emit photoresist-curative electromagnetic radiation. The light guide (110) is arranged to receive the photoresist-curative electromagnetic radiation from the light source (130) and to guide the received radiation by total internal reflection, the light guide (110) including a pattern of emission points (210) on at least one surface of the light guide (110), the emission points (210) emitting the photoresist-curative electromagnetic radiation out of the light guide (110) by frustration of total internal reflection caused by the emission points (210).

Abstract: The systems and methods of the present disclosure provide an opto-electronic print media. The opto-electronic print media can include a diffusion film having a printable surface and a second surface opposite the printable surface. The opto-electronic print media can include a light guide coupled to the second surface of the diffusion film. The opto-electronic print media can include a solar panel coupled to the light guide that captures light passing through the diffusion film and the light guide. The opto-electronic print media is feedable through a printer. The systems and methods of this present disclosure further provide a printable solar-powered sign. The printable solar powered sign can include a sheet structure. The sheet structure can include a diffusion film, a light guide, a solar panel, and a light source. The sheet structure can be passable through a printer such that the printer can print on the diffusion film.

Abstract: The systems and methods of the present disclosure provide film-ready solar signs and assemblies for installations of solar signs.

Abstract: The systems and methods of the present disclosure provide connectable tiles that can form a self-contained illuminated sign of potentially unlimited size. The self-contained illuminated sign can include one or more tiles. A tile can include a diffusion film having a surface to be illuminated. The tile can include a light guide plate coupled to the diffusion film. The light guide can be configured to evenly distribute light through the diffusion film. The tile can include a solar panel coupled to the light guide. The solar panel can capture light that passes through the diffusion film and the light guide. The tile can include a light source positioned adjacent to the light guide that receives stored electrical power from a battery electrically coupled to the solar panel. The tile can include a connector configured to attach the tile to a second tile.

Abstract: A targeted drug delivery device comprises a brush for use in delivery of one or more therapeutic agents during surgical procedures, including but not limited to, heart, chest, abdominal, brain, limb, vascular, eye, organ transplantation surgery or cancer surgical treatment. The therapeutic agent is selected from the group consisting of genetically engineered vectors or cells, proteins, stem cells, small molecule pharmaceuticals, drugs or biologics. Methods of treating diseases comprising delivering at least one therapeutic agent to a patient's organs or tissues using any one of the targeted drug delivery devices are disclosed.

Abstract: The present invention relates to a targeted cardiac therapy device that can precisely deliver therapeutic compounds to desired locations on, around or within the heart of a patient, and methods of treating conduction system disease, sinus node dysfunction, atrial fibrillation, myocardial infarction, and heart failure, using the described devices to deliver genetically engineered vectors or cells, proteins, stem cells, small molecule pharmaceuticals and biologics.

Abstract: The present invention relates to a targeted cardiac therapy device that can precisely deliver therapeutic compounds to desired locations on, around or within the heart of a patient, and methods of treating conduction system disease, sinus node dysfunction, atrial fibrillation, myocardial infarction, heart failure, and muscular diseases with cardiac involvement, using the described devices to deliver genetically engineered vectors or cells, proteins, stem cells, small molecule pharmaceuticals and biologics.

Abstract: In some aspects, the disclosure relates methods for identifying ventricular tachycardia in subjects, e.g., subjects who have previously experienced a myocardial infarction. In some embodiments, methods of the disclosure comprise measuring action potential durations and/or expression levels of KCNE3 and/or KCNE4 in a subject. In some aspects, the disclosure relates to methods and compositions for reducing or inhibiting the activity of KCNE3 and/or KCNE4, for example, in subjects having ventricular tachycardia.

Abstract: A clamping and connection system configured to be pivotally attached to two pieces of equipment such as an IV pole and a hospital bed. The clamping and connection system includes a clamping portion and an attachment portion. The system is configured to be rotatable around the attachment portion to allow optimal placement of the pole while in transport and connected to the bed.

Abstract: A one-way see-through illumination device includes a light guide, a light source at an edge of the light guide and a pattern of pixels on a surface of the light guide. The light guide has an illumination surface and a non-illumination surface opposite to the illumination surface. The light source is configured to inject light into the edge of the light guide. The pattern of pixels and the light guide are arranged to generate transparent illumination by the frustration of total internal reflection of light injected into the light guide such that light from the light source is emitted through the illumination surface. The pixels are arranged to prevent the generation of a diffraction grating in the light guide.

Abstract: A device (100) includes a light source (130) and a light guide (110). The light source (130) is configured to emit photoresist-curative electromagnetic radiation. The light guide (110) is arranged to receive the photoresist-curative electromagnetic radiation from the light source (130) and to guide the received radiation by total internal reflection, the light guide (110) including a pattern of emission points (210) on at least one surface of the light guide (110), the emission points (210) emitting the photoresist-curative electromagnetic radiation out of the light guide (110) by frustration of total internal reflection caused by the emission points (210).

Abstract: A clamp for mounting a structure on a support. The clamp includes a fixed jaw, a base, and a moveable thruster plate between the fixed jaw and the base. The clamp includes a thruster cylinder configured to be rotatably received through the clamp body and having threads that engage a screw so that when the thruster cylinder rotates, the screw is advanced or retracted to move the thruster plate into and out of engagement with the support. A knob is used to rotate the thruster cylinder. The clamp includes a friction washer or collet located between the thruster cylinder and the clamp body. The clamp is configured so that when the thruster plate engages the support, further axial movement of the screw is prevented and further rotation of the knob and thruster cylinder compresses the friction washer or collet.