Patents by Inventor Kevin Donald George Pfleger

Kevin Donald George Pfleger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240009191
    Abstract: A pharmaceutical formulation comprising at least one angiotensin type 1 receptor (AT1R) blocker and at least one CXC chemokine receptor 2 (CXCR2) pathway inhibitor.
    Type: Application
    Filed: September 18, 2020
    Publication date: January 11, 2024
    Inventors: Robert Pearson Shepherd, Kevin Donald George Pfleger
  • Publication number: 20220169693
    Abstract: The invention relates to modulators of activation of Immunoglobulin Superfamily Cell Adhesion Molecules (IgSF CAMs) and modulators of activation of Receptor for Advanced Glycation End Products (RAGE) as well as screening assays for identifying modulators of activation of molecules associated with certain diseases and/or conditions in which IgSF CAMs and/or RAGE are implicated, and to medicaments and methods of treatment comprising administration of such modulators.
    Type: Application
    Filed: December 10, 2019
    Publication date: June 2, 2022
    Inventors: Kevin Donald George PFLEGER, Merlin Christopher THOMAS, Raelene Jane PICKERING, Carlos ROSADO, Elizabeth Katherine Mary JOHNSTONE
  • Publication number: 20200207836
    Abstract: A method of screening candidate agents for their ability to modulate RAGE activity where such RAGE activity is induced by an active co-located GPCR, the method comprising the steps of: contacting a RAGE polypeptide with a GPCR polypeptide in the presence of a candidate agent where the GPCR polypeptide is constitutively active and/or is activated by addition of an agonist, partial agonist or allosteric modulator of that GPCR; and detecting whether the candidate agent is a modulator of RAGE ligand-independent activation of RAGE by activated co-located GPCR by detecting an effect indicative of modulation of RAGE activation by the presence of the candidate agent and/or by detecting RAGE-dependent signalling that is modulated by the presence of the candidate agent.
    Type: Application
    Filed: August 21, 2018
    Publication date: July 2, 2020
    Inventors: Kevin Donald George PFLEGER, Merlin Christopher THOMAS, Raelene Jane PICKERING, Carlos ROSADO, Christos TIKELLIS
  • Patent number: 8568997
    Abstract: A system for the detection of molecular associations, the system comprising: i) a first agent, comprising a first interacting group coupled to a first reporter component; ii) a second agent, comprising a second interacting group coupled to a second reporter component; iii) a third agent, comprising a third interacting group; iv) a modulator; and v) a detector; wherein proximity of the first and second reporter components generates a signal capable of detection by the detector; and wherein the modulator modulates the association of the second interacting group with the third interacting group; such that monitoring the signal generated by proximity of the first and second reporter components by the detector constitutes monitoring the association of the first and third agents.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: October 29, 2013
    Assignee: Dimerix Bioscience Pty Ltd.
    Inventors: Kevin Donald George Pfleger, Ruth Marie Seeber, Heng Boon See, Karin Ann Eidne
  • Publication number: 20120100130
    Abstract: A hetero-dimeric or hetero-oligomeric receptor, comprising at least one chemokine receptor subunit associated with at least one angiotensin receptor subunit.
    Type: Application
    Filed: March 26, 2010
    Publication date: April 26, 2012
    Applicant: DIMERIX BIOSCIENCE PTY LTD.
    Inventors: Kevin Donald George Pfleger, Matthew Blake Dalrymple, James Williams, Elizabeth McCall
  • Publication number: 20100234417
    Abstract: A hetero-dimeric or hetero-oligomeric receptor, comprising at least one thyrotropin releasing hormone receptor subunit associated with at least one orexin receptor subunit.
    Type: Application
    Filed: November 9, 2007
    Publication date: September 16, 2010
    Applicant: DIMERIX BIOSCIENCE PTY LTD.
    Inventors: Kevin Donald George Pfleger, Ruth Marie Seeber, Heng See Boon, Karin Ann Eidne
  • Publication number: 20100021457
    Abstract: A system for the detection of molecular associations, the system comprising: i) a first agent, comprising a first interacting group coupled to a first reporter component; ii) a second agent, comprising a second interacting group coupled to a second reporter component; iii) a third agent, comprising a third interacting group; iv) a modulator; and v) a detector; wherein proximity of the first and second reporter components generates a signal capable of detection by the detector; and wherein the modulator modulates the association of the second interacting group with the third interacting group; such that monitoring the signal generated by proximity of the first and second reporter components by the detector constitutes monitoring the association of the first and third agents.
    Type: Application
    Filed: November 9, 2007
    Publication date: January 28, 2010
    Applicant: DIMERIX BIOSCIENCE PTY LTD.
    Inventors: Kevin Donald George Pfleger, Ruth Marie Seeber, Heng Boon See, Karin Ann Eidne