Abstract: Disclosed is a pharmaceutical inhibitor for the treatment of lipedema in a subject. The inhibitor comprises a mast cell stabilizer comprising sodium cromoglycate, but can be selected from a group of compounds that includes nedocromil, ketotifen, disodium chromoglycate, olopatadine, and amlexanox. The inhibitor can be administered as a composition or topical cream. The dosage of sodium cromoglycate can be about 500 mg for the composition or a 4% concentration for the topical cream. The treatment regimen can involve oral administration of the sodium cromoglycate composition or epicutaneous administration of the sodium cromoglycate cream. The treatment reduces histamine levels and mast cell degranulation, thereby inhibiting the growth and proliferation of adipose tissue cells, which prevents an increase in the size or mass of the tissue. This invention provides a new approach for treating lipedema, which can improve the quality of life for individuals affected by this condition.

Abstract: The traditional filters used in cigarettes are found to be ineffective in trapping the toxic chemical compounds which cigarette produces during combustion. The current invention aims to provide systems and methods (or to a universal filter) to reduce amines and nitrosamines in cigarette smoke vapors through a filter functionalized with olive tree polyphenols. Amines and Nitrosamines are highly toxic chemicals in the smoke and aerosol of a combusted cigarette. Olive polyphenols are able to trap amines and nitrosamines by establishing weak and strong interactions with these compounds by trapping these compounds in the filter.

Abstract: The present invention identifies further to AKR1C1 also AKR1C2 as a lipedema-associated gene. The invention provides methods for diagnosing or assessing an individual's susceptibility to lipedema by the analysis of the AKR1C genes, in particular of the AKR1C2 gene, or the expression levels of its product and related metabolites. Also provided are therapeutic methods for treating a patient or methods for prophylactically treating an individual susceptible to lipedema.