Patents by Inventor Kevin Douglas Kreutter

Kevin Douglas Kreutter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alkylquinoline and alkylquinazoline kinase modulators
    Patent number: 8071768
    Abstract: The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula I: wherein R1, R2, R3, B, Z, G, Q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3 and/or c-kit and/or TrkB, the use of such compounds to reduce or inhibit kinase activity of FLT3 and/or c-kit and/or TrkB in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 and/or c-kit and/or TrkB. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
    Type: Grant
    Filed: June 6, 2006
    Date of Patent: December 6, 2011
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Nand Baindur, Michael David Gaul, Kevin Douglas Kreutter, Christian Andrew Baumann, Alexander J. Kim, Guozhang Xu, Robert W. Tuman, Dana L. Johnson
  • Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
    Patent number: 7825244
    Abstract: The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: wherein R1, R2, R99, and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.
    Type: Grant
    Filed: June 6, 2006
    Date of Patent: November 2, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nand Baindur, Michael David Gaul, Kevin Douglas Kreutter, Guozhang Xu
  • THIENOPYRIMIDINE AND THIENOPYRIDINE KINASE MODULATORS
    Publication number: 20090163710
    Abstract: The invention is directed to thienopyrimidines and thienopyridines compounds of Formula I and Formula II: where R1, R3, B, Z, Q, p, q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3, the use of such compounds to reduce or inhibit kinase activity of FLT3 in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
    Type: Application
    Filed: January 30, 2009
    Publication date: June 25, 2009
    Inventors: Michael David Gaul, Kevin Douglas Kreutter, Christian Andrew Baumann
  • THIENOPYRIMIDINE AND THIENOPYRIDINE KINASE MODULATORS
    Publication number: 20090143378
    Abstract: The invention is directed to thienopyrimidines and thienopyridines compounds of Formula I and Formula II: where R1, R3, B, Z, Q, p, q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3, the use of such compounds to reduce or inhibit kinase activity of FLT3 in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
    Type: Application
    Filed: January 30, 2009
    Publication date: June 4, 2009
    Inventors: Michael David Gaul, Kevin Douglas Kreutter, Christian Andrew Baumann