Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

Abstract: Operation of a DI HCCI engine is optimized for maximizing load capability and load ranges via matching fuel ignitability with the compression ratio of the engine.

Abstract: This invention relates to the newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 proteins.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: Invented is the compound (5Z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5H)-one, and/or pharmaceutically acceptable salts, hydrates, solvates and pro-drugs thereof. Also invented are pharmaceutical compositions containing this compound, methods of preparing this compound and pharmaceutically acceptable salts, hydrates, solvates and pro-drugs thereof. Also invented are methods of using this compound as an inhibitor of hYAK3 proteins.

Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

Abstract: A method of operating an internal combustion engine including at least one cylinder and a piston slidable in the cylinder is provided. In at least one embodiment, the method includes: supplying a mixture of pressurized air and recirculated exhaust gas from an intake manifold to an air intake port of a combustion chamber in the cylinder; operating an air intake valve to open the air intake port to allow the pressurized air and exhaust gas mixture to flow between the combustion chamber and the intake manifold during a portion of a compression stroke of the piston; and operably controlling a fuel supply system to inject fuel into the combustion chamber via a common rail fuel injector.

Abstract: An engine and a method of operating an internal combustion engine is provided. The method comprises supplying a pressurized air from an intake manifold to an air intake port of a combustion chamber in the cylinder, operating an air intake valve to open the air intake port to allow the pressurized air and exhaust gas mixture to flow between the combustion chamber and the intake manifold during a portion of a compression stroke of the piston, and operating the engine in an HCCI combustion mode. In at least some embodiments, a mixture of pressurized air and recirculated exhaust gas is supplied from an intake manifold to an air intake port of a combustion chamber in the cylinder. In some embodiments, the method further comprises causing an exhaust stream of an engine to contact a NOx adsorber.

Abstract: Engines and methods of controlling an engine may involve at least one fluid actuators associated with one or more engine intake and/or exhaust valves. Timing of valve closing/opening and use of an air supply system may enable engine operation according to a Miller cycle.

Abstract: An engine and method of operating an internal combustion engine with either a continuously variable speed transmission or electric drive is provided. The engine and method comprises operating the engine at its optimum engine speed throughout a range of vehicle speeds through, supplying pressurized air from an intake manifold to an air intake port of a combustion chamber in the cylinder, and operating an air intake valve to open the air intake port to allow the pressurized air to flow between the combustion chamber and the intake manifold during a portion of a compression stroke of the piston. In at least one embodiment, the engine and method further comprises using a mixture of pressurized air and recirculated exhaust gas.

Abstract: An engine and method of operating an internal combustion engine is provided. The method comprises supplying pressurized air from an intake manifold to an air intake port of a combustion chamber in the cylinder, operating an air intake valve to open the air intake port to allow the pressurized air to flow between the combustion chamber and the intake manifold during a portion of a compression stroke of the piston, and filtering particulate matter from an exhaust stream of the engine with a particulate filter.

Abstract: A method of operating an engine system should produce relatively low concentrations of various emissions without compromising a desired power output of the system. In order to operate an engine system of the present disclosure, a predetermined total amount of fuel injected into at least one combustion chamber is apportioned into at least a first amount and a second amount of fuel. The first amount of fuel is injected into the at least one combustion chamber during non-auto ignition conditions. The second amount of fuel is injected into the at least one combustion chamber during auto-ignition conditions. When the engine system is in a mid-low engine load range, the second amount of fuel is one of equal to or less than 15% of the predetermined total amount of fuel. When the engine system is in a high engine load range, the second amount of fuel is greater than 15% of the predetermined total amount of fuel.

Abstract: A method of mixed mode operation of an internal combustion engine includes the steps of controlling a homogeneous charge combustion event timing in a given engine cycle, and controlling a conventional charge injection event to be at least a predetermined time after the homogeneous charge combustion event. An internal combustion engine is provided, including an electronic controller having a computer readable medium with a combustion timing control algorithm recorded thereon, the control algorithm including means for controlling a homogeneous charge combustion event timing and means for controlling a conventional injection event timing to be at least a predetermined time from the homogeneous charge combustion event.

Abstract: A method of operating an internal combustion engine is provided. The method includes injecting a first fuel charge into at least one cylinder of the engine. The method further includes determining a value indicative of at least one of a cylinder pressure and a rate of change in cylinder pressure. The method further includes injecting a second fuel charge into the at least one cylinder, upon the occurrence of a predetermined contingency, which may be a determined cylinder pressure or rate in change thereof exceeding a predetermined threshold. An internal combustion engine is further provided, including an electronic controller having a control algorithm. The control algorithm includes software for determining a value indicative of at least one of a cylinder pressure and a rate of change in cylinder pressure of at least one cylinder of the engine.

Abstract: The present invention comprises an impermeable coating on an organic substrate resulting in a material that is inert, environmentally safe, impermeable and fully compostable and biodegradable. The present invention, therefore, is ideally suited to meet the ever-growing demand for compostable containers, as used in the food, beverage, agricultural, consumer products, medical, and waste industries, for example, including vacuum packaging and anti-static packaging. A possible substrate, such as a cellulose or polyactide (PLA) film and a possible coating, such as a ceramic coating of SiO2 (silicon di-oxide), are derived from organic substances and, thus, both completely degrade under natural conditions. Moreover, this biodegradation can occur under compost conditions as defined in numerous international standards, including at least ASTM D 6400.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: A method and apparatus for operating a compression ignition engine having a cylinder wall, a piston, and a head defining a combustion chamber. The method and apparatus includes delivering fuel substantially uniformly into the combustion chamber, the fuel being dispersed throughout the combustion chamber and spaced from the cylinder wall, delivering an oxidant into the combustion chamber sufficient to support combustion at a first predetermined combustion duration, and delivering a diluent into the combustion chamber sufficient to change the first predetermined combustion duration to a second predetermined combustion duration different from the first predetermined combustion duration.

Abstract: A method of operating an internal combustion engine includes operating the engine in a first combustion mode. The method also includes switching operation of the engine to a second combustion mode. The method includes directing an exhaust stream of the engine into contact with a NOx adsorber substantially only during the operation in the second combustion mode.