Abstract: An oral feline feed and a method of controlling ticks in a feline in need thereof by orally administering to the feline a daily feed comprising an effective amount of a isoxazoline for an effective time to thereby cause the amount of isoxazoline in the feline's blood to rise to and maintain at a therapeutically effective level for controlling ticks.

Abstract: An oral feline feed and a method of controlling fleas in a feline in need thereof by orally administering to the feline a daily feed comprising an effective amount of an isoxazoline for an effective time to thereby cause the amount of isoxazoline in the feline's blood to rise to and maintain at a therapeutically effective level for controlling fleas.

Abstract: An oral feline feed and a method of controlling fleas in a feline in need thereof by orally administering to the feline a daily feed comprising an effective amount of a spinosyn for an effective time to thereby cause the amount of spinosyn in the feline's blood to rise to and be maintained at a therapeutically effective level for controlling fleas.

Abstract: An oral canine feed and a method of controlling fleas in a canine in need thereof by orally administering to the canine a daily feed comprising an effective amount of a isoxazoline for an effective time to thereby cause the amount of isoxazoline in the canine's blood to rise to and maintain at a therapeutically effective level for controlling fleas.

Abstract: An oral animal feed and a method of controlling ticks in a mammal in need thereof by orally administering to the mammal an effective amount of a spinosyn for an effective time to thereby cause the amount of spinosyn in the mammal's blood to rise to and maintain at a therapeutically effective level for controlling ticks.

Abstract: An oral animal feed and a method of controlling fleas in a canine in need thereof by orally administering to the canine a daily feed comprising an effective amount of a spinosyn for an effective time to thereby cause the amount of spinosyn in the canine's blood to rise to and be maintained at a therapeutically effective level for controlling fleas.

Abstract: An oral canine feed and a method of controlling ticks in a canine in need thereof by orally administering to the canine an effective amount of a isoxazoline for an effective time to thereby cause the amount of isoxazoline in the canine's blood to rise to and maintain at a therapeutically effective level for controlling ticks.

Abstract: Orally administrating an active material to a mammal on a substantially daily basis, thereby increasing the blood concentration of the active material to an amount effective to control a flea and/or tick infestation in the mammal. Discontinuing administration for at least one day, while maintaining the concentration of the active material at a level that controls the flea and/or tick infestation. After the period of time has elapsed, resuming substantially daily dosing to maintain the blood concentration of the active material in an amount effective to control the flea and/or tick infestation. Also disclosed is a method for establishing a regimen for administering an active material for controlling flea and/or tick infestations in a mammal using a dosage that lower than the label dose for a corresponding time-period.