Abstract: The present disclosure relates to compounds that act as inhibitors of NLRP3 inflammasomes; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with inflammation and inflammaging, including hearing loss and other diseases associated with aging.

Abstract: An erratic driver detection system for a host vehicle. The system includes a sensor configured to measure a distance between the host vehicle and a detected neighboring vehicle, and output sensor data. The system also includes an electronic processor connected to the sensor and configured to build an expected driving behavior model and a target driving behavior model corresponding to the detected neighboring vehicle based on the sensor data. The target driving behavior model includes past, present, and predicted trajectories of the detected neighboring vehicle. The electronic processor is also configured to determine a difference between the target driving behavior model and the expected driving behavior model, identify an instance of erratic driving with respect to the detected neighboring vehicle based on the difference. In response to identifying the instance of erratic driving, the electronic processor controls the vehicle to perform a safety action.

Abstract: The present disclosure relates to compounds that act as inhibitors of NLRP3 inflammasomes; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with inflammation and inflammaging, including hearing loss and other diseases associated with aging.

Abstract: The present disclosure relates to compounds that act as inhibitors of NLRP3 inflammasomes; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with inflammation and inflammaging, including hearing loss and other diseases associated with aging.

Abstract: Controlled-release preparations of oxcarbazepine and derivatives thereof for once-a-day administration are disclosed. The inventive compositions comprise solubility- and/or release enhancing agents to provide tailored drug release profiles, preferably sigmoidal release profiles. Methods of treatment comprising the inventive compositions are also disclosed.

Abstract: A hybrid water storage system for an aircraft includes separate variable volumes for respectively storing/holding potable water and gray water occupying a common container. The hybrid water storage system is generally configured to draw potable water from a first variable volume in order to provide fresh water to one or more aircraft appliances (e.g., sinks, showers, ice-makers, etc.), and the used potable water (i.e., the potable water that is collected in drains from the aircraft appliances), referred to herein as gray water, is routed to a second variable volume that occupies the same container as the first variable volume.

Abstract: Disclosed is an encoding and decoding system and associated methods for producing a compressed waveform that encodes data points of a point cloud in a format and size that may be transmitted over a data network, decompressed, decoded, and rendered on a remote device without the buffering or lag associated with transmitting and rendering an uncompressed point cloud. The encoder receives a request from a remote device to access the point cloud, encodes a set of data points from the point cloud as one or more signals derived from values defined for the positional and non-positional elements of each data point from the set of data points, generates one or more compressed waveforms from compressing the one or more signals and transmits the one or more compressed waveforms to the remote device in response to the request for decompression, decoding, and image rendering.

Abstract: A thermal management system of a gas turbine engine, the thermal management system including: a thermal transport bus configured to have a heat exchange fluid flowing therethrough and including a pump including a plurality of bearings; an auxiliary thermal bus in thermal communication with the plurality of bearings; and an auxiliary heat exchanger in thermal communication with the auxiliary thermal bus.

Abstract: A thermal management system including a fluid flow mechanism. The fluid flow mechanism includes an electric machine. A conduit is formed through the electric machine allowing a heat transfer fluid to flow therethrough. The fluid flow mechanism includes a flow device configured to provide a first portion of the heat transfer fluid to a first heat exchange circuit and a second portion of heat transfer fluid to a second heat exchange circuit. The conduit is in fluid communication with the second heat exchange circuit.

Abstract: The various implementations described herein include a video camera assembly that includes: (1) a housing; (2) an image sensor encased in the housing and configured to capture activity of the smart home environment; (3) a wireless radio configured to transmit video frames captured by the image sensor to an electronic device via a remote server; (4) at least one infrared transmitter configured to selectively illuminate the smart home environment; (5) one or more circuit boards encased in the housing, the one or more circuit boards including at least one processor mounted thereon; and (6) a heating component coupled to the image sensor, the heating component configured to continuously maintain the image sensor at a temperature above a threshold temperature while the image sensor is capturing the activity of the smart home environment.

Abstract: A hybrid water storage system for an aircraft includes separate variable volumes for respectively storing/holding potable water and gray water occupying a common container. The hybrid water storage system is generally configured to draw potable water from a first variable volume in order to provide fresh water to one or more aircraft appliances (e.g., sinks, showers, ice-makers, etc.), and the used potable water (i.e., the potable water that is collected in drains from the aircraft appliances), referred to herein as gray water, is routed to a second variable volume that occupies the same container as the first variable volume.

Abstract: The present disclosure relates to compounds that act as inhibitors of NLRP3 inflammasomes; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with inflammation and inflammaging, including hearing loss and other diseases associated with aging.

Abstract: A pump system to pressurize a fluid within a closed loop transport bus is disclosed herein. The example of the pump system disclosed herein includes a pump, including an impeller, to increase kinetic energy of a fluid flowing through the impeller; an electric motor, including a rotor shaft connected to the impeller, to provide torque to the rotor shaft; a first bearing to support the rotor shaft at a first operational speed range, the first bearing coupled to an inner race; a second bearing to support the rotor shaft at a second operational speed range, the rotor shaft coupled to an outer race; and one or more sprag elements configured to: engage the inner race with the outer race at the first operational speed range; and disengage the inner race from the outer race at the second operational speed range.

Abstract: A system and process use artificial intelligence to evaluate the toxicity of drugs on cells. In some embodiments, a convolutional neural network is trained to identify features in cells and thereafter identify when structural changes in cells are signs of damage from exposure to a drug. Some embodiments use a 2-class deep neural network, comparing drug-treated cells to controls, to learn which images may show signs of toxicity as a result of the drug. In some applications, the system may capture images from a time-lapse experiment to determine from the cell cultures how a drug affects a cell type over time.

Abstract: Disclosed is a system and associated methods for generating a mutable tree to efficiently access data within a three-dimensional (“3D”) environment. The system generates the mutable tree with a root node defined at a root node position, a first branch with nodes for each of a first set of subdivided regions that are a first distance from the root node position, and a second branch with nodes for each of a second set of subdivided regions that are a second distance from the root node position. The system sorts the mutable tree in response to a request to access data from a first position within the 3D environment so that the first node in the first branch is the first subtree node that is closest to the first position, and the first node in the second branch is the second subtree node that is closest to the first position.

Abstract: A gas turbine engine assembly includes a gas turbine engine with a combustion section, a fuel delivery system, and a thermal energy management system. The fuel delivery assembly provides a fuel to the combustion section of the gas turbine engine. The thermal energy management system includes a thermal transport bus, a heat source heat exchanger, and a heat sink heat exchanger. The thermal transport bus has a portion of the fuel configured to flow therethrough. The fuel is disposed as a heat exchange fluid of the thermal energy management system. The heat source heat exchanger is in thermal communication with the flow of fuel through the transport bus. The heat sink heat exchanger is in thermal communication with the flow of fuel through the transport bus.

Abstract: Disclosed are a mobile device and method which include acquiring, by an image acquisition unit installed in a mobile device, an image of eyes of a patient while light provided by a light source reflects from an optical surface of the eyes of the patient; and obtaining, by a processor installed in the mobile device, ocular misalignment measurements, including a magnitude and a direction of ocular misalignment in the eyes of the patient, using the acquired image or set of images.

Abstract: A method is provided for operating a thermal management system of a gas turbine engine. The method includes: operating the gas turbine engine to start-up the gas turbine engine; receiving data indicative of a state of a thermal transport bus of the thermal management system using a sensor, the state of the thermal transport bus including a phase of a thermal fluid within the thermal transport bus; and starting a pump of a pump assembly in response to receiving data indicative of the state of the thermal transport bus of the thermal management system, the pump in fluid communication with the thermal transport bus.

Abstract: Disclosed is an encoding and decoding system and associated methods for producing a compressed waveform that encodes data points of a point cloud in a format and size that may be transmitted over a data network, decompressed, decoded, and rendered on a remote device without the buffering or lag associated with transmitting and rendering an uncompressed point cloud. The encoder receives a request from a remote device to access the point cloud, encodes a set of data points from the point cloud as one or more signals derived from values defined for the positional and non-positional elements of each data point from the set of data points, generates one or more compressed waveforms from compressing the one or more signals and transmits the one or more compressed waveforms to the remote device in response to the request for decompression, decoding, and image rendering.

Abstract: The present disclosure relates to compounds that act as inhibitors of NLRP3 inflammasomes; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with inflammation and inflammaging, including hearing loss and other diseases associated with aging; wherein the inhibitors of NLRP3 inflammasomes are compounds of Formula VII: or a pharmaceutically acceptable salt thereof.