Abstract: In one aspect, the disclosure relates to substituted N-(2-(2,6-dioxopiperidinyl-3-yl)-1,3-dioxoisoindolin-5-yl)arylsulfonamide analogs that useful as modulators of cereblon (CRBN) activity, methods of making same, pharmaceutical compositions comprising same, and methods of treating various clinical conditions and disorders using same, e.g., a disorder of uncontrolled cellular proliferation, such as a cancer, which may be associated with cereblon protein dysfunction and/or a GSPT1 dysfunction. In various further aspects, the disclosed compounds can selectively modulate the degradation of GSPT1 protein, i.e., the disclosed compounds can act as GSPT1 degraders. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: Z maps combined with a standardized stimulus in the form of a targeted arterial partial pressures of carbon dioxide provide suprisingly enhanced images for the assessment of pathological CVR. For example, the z-map assessment of patients with known steno-occlusive diseases of the cervico-cerebral vasculature showed an enhanced resolution of the presence, localization, and severity of the pathological CVR. Z-map have been found to be useful to reduce the confounding effects of test-to-test, subject-to-subject, and platform-to-platform variability for comparison of CVR images showing the importance of combining this analysis with the standardized stimulus.

Abstract: Data account management systems and methods are described. A server is in communication with one or more information source systems, at least one user device associated with at least one user and one or more electronic data accounts associated with the user. The server links the electronic data accounts, monitors data among the information source systems and the linked accounts for any changes in activity associated with the user, predicts a behavioral activity of the user via machine learning based on at least one of the monitored data and historical data associated with the user, identifies at least one notification instruction specific to the user based on the predicted behavioral activity, and generates an interactive graphical user interface (GUI) for display on the user device. The interactive GUI presents one or more of the notification instruction and a user profile of the at least one user among the linked accounts.

Abstract: An Antenna Positioning System for missile seeker and system development and test comprises an antenna module, and a plurality of tethers, wherein the antenna module is suspended in a position by the tethers and the position is capable of being changed and the antenna module manoeuvred by pulling at least one tether and simultaneously releasing at least one tether. The system is useful for testing and developing Radio Frequency (RF) missile technology in a controlled, simulated environment rather than by live missile firings.

Abstract: A proppant container facilitates the transportation of wet sand for use in a hydraulic fracturing operation. The container is mounted in a cradle that tips downward in arcuate motion for discharge or proppant through a top opening The tipping mechanism may be driven by a system of gears or a hydraulic ram.

Abstract: A proppant container facilitates the transportation of wet sand for use in a hydraulic fracturing operation. The container is mounted in a cradle that tips downward in arcuate motion for discharge or proppant through a top opening The tipping mechanism may be driven by a system of gears or a hydraulic ram.

Abstract: A proppant container facilitates the transportation of wet sand for use in a hydraulic fracturing operation. The proppant container is provided with a system for dislodging the wet sand for subsequent use. This may be done by use of a vibrator or an umbrella valve. In another aspect, the proppant container may be used in combination with a rack having a wash system that slurries the proppant for delivery to a blender tub without necessarily resorting to use of a conveyor belt.

Abstract: A tailsitter aircraft includes an airframe having first and second wings with first and second pylons extending therebetween, a thrust array attached to the airframe, payloads and payload saddle assemblies coupled to the pylons each configured to secure a respective payload. The thrust array includes propulsion assemblies configured to transition the airframe between a forward flight orientation for wing-borne lift and a VTOL orientation for thrust-borne lift. Each payload saddle assembly includes a latch assembly and a retainer configured to secure the respective payload against a respective pylon. A latch assembly is movable between various positions including an open position and a closed position and is configured to secure the respective payload in the closed position and release the respective payload in the open position. Each latch assembly is configured to move from the closed position to the open position to release the respective payload in the VTOL orientation.

Abstract: Data account management systems and methods are described. A server is in communication with one or more information source systems, at least one user device associated with at least one user and one or more electronic data accounts associated with the user. The server links the electronic data accounts, monitors data among the information source systems and the linked accounts for any changes in activity associated with the user, predicts a behavioral activity of the user via machine learning based on at least one of the monitored data and historical data associated with the user, identifies at least one notification instruction specific to the user based on the predicted behavioral activity, and generates an interactive graphical user interface (GUI) for display on the user device. The interactive GUI presents one or more of the notification instruction and a user profile of the at least one user among the linked accounts.

Abstract: Data account management systems and methods are described. A server is in communication with one or more information source systems, at least one user device associated with at least one user and one or more electronic data accounts associated with the user. The server links the electronic data accounts, monitors data among the information source systems and the linked accounts for any changes in activity associated with the user, predicts a behavioral activity of the user via machine learning based on at least one of the monitored data and historical data associated with the user, identifies at least one notification instruction specific to the user based on the predicted behavioral activity, and generates an interactive graphical user interface (GUI) for display on the user device. The interactive GUI presents one or more of the notification instruction and a user profile of the at least one user among the linked accounts.

Abstract: A proppant container facilitates the transportation of wet sand for use in a hydraulic fracturing operation. The container is mounted in a cradle that tips downward in arcuate motion for discharge or proppant through a top opening The tipping mechanism may be driven by a system of gears or a hydraulic ram.

Abstract: A proppant container facilitates the transportation of wet sand for use in a hydraulic fracturing operation. A metering conveyor is positioned between a blender tub and a proppant motive mechanism, such as a conveyor or wash system that receives discharge direct from proppant containers of the type normally used to transport sand in support of a hydraulic fracturing operation. The metering conveyor is fitted with equipment including an intermediate surge hopper with a vibration system and a knife-edge gate that may be used to facilitate the operational movement of sand.

Abstract: A proppant container facilitates the transportation of wet sand for use in a hydraulic fracturing operation. A metering conveyor is positioned between a blender tub and a proppant motive mechanism, such as a conveyor or wash system that receives discharge direct from proppant containers of the type normally used to transport sand in support of a hydraulic fracturing operation. The metering conveyor is fitted with equipment including a knife-edge gate that may be used to facilitate flow control operations.

Abstract: A proppant container facilitates the transportation of wet sand for use in a hydraulic fracturing operation. The proppant container is provided with a system for dislodging the wet sand for subsequent use. This may be done by use of a vibrator or an umbrella valve. In another aspect, the proppant container may be used in combination with a rack having a wash system that slurries the proppant for delivery to a blender tub without necessarily resorting to use of a conveyor belt.

Abstract: A conveyor sled assembly is utilized to supply proppant in support of oilfield hydraulic fracturing operations. The conveyor sled assembly includes precisely positioned components where tolerances between components are so small as to prevent significant spillage at component junction boundaries. This manner of fitting proppant pods onto the conveyor sled assembly increases predictability of which pods will discharge their proppant load first. This enhances reliability of the overall proppant delivery system.

Abstract: A proppant container facilitates the transportation of wet sand for use in a hydraulic fracturing operation. The proppant container is provided with a system for dislodging the wet sand for subsequent use. This may be done by use of a vibrator or an umbrella valve. In another aspect, the proppant container may be used in combination with a rack having a wash system that slurries the proppant for delivery to a blender tub without necessarily resorting to use of a conveyor belt.

Abstract: An engine system includes a gearbox assembly that includes a housing having plural interconnected gears disposed between an engine side of the housing and an alternator side of the housing, a rotatable engine coupler connected with the engine side of the housing, the engine coupler configured to engage a rotatable shaft of an engine, and a rotatable alternator coupler connected with the alternator side of the housing, the alternator coupler configured to engage a rotor of a first alternator. The housing is configured to be positioned between the engine and the first alternator. The engine coupler is configured to engage the engine that is resiliently mounted in the powered system and the alternator coupler is configured to engage the first alternator that is rigidly mounted in the powered system to transfer rotation of the shaft of the engine to rotation of the rotor of the first alternator.

Abstract: An article of footwear includes a sole, an upper defining a foot cavity, and a brace member. The brace member is comprised of a non-elastic resilient material. The brace member is positioned within a pocket in the upper and extends from a heel portion to above an ankle portion of the upper. The brace member may be provided with a top plate member and a base plate member with a central shaft extending between the top plate member and the base plate member. The central shaft may have a C-shape that curves around an ankle of a human foot positioned within the foot cavity.

Abstract: Data account management systems and methods are described. A server is in communication with one or more information source systems, at least one user device associated with at least one user and one or more electronic data accounts associated with the user. The server links the electronic data accounts, monitors data among the information source systems and the linked accounts for any changes in activity associated with the user, predicts a behavioral activity of the user via machine learning based on at least one of the monitored data and historical data associated with the user, identifies at least one notification instruction specific to the user based on the predicted behavioral activity, and generates an interactive graphical user interface (GUI) for display on the user device. The interactive GUI presents one or more of the notification instruction and a user profile of the at least one user among the linked accounts.

Abstract: A proppant container facilitates the transportation of wet sand for use in a hydraulic fracturing operation. A metering conveyor is positioned between a blender tub and a proppant motive mechanism, such as a conveyor or wash system that receives discharge direct from proppant containers of the type normally used to transport sand in support of a hydraulic fracturing operation. The metering conveyor is fitted with sensors and/or a knife-edge gate that may be used to facilitate flow control operations.