Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting X-Box Protein 1 (XBP-1), and methods of using the dsRNA to inhibit expression of XBP-1.

Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the proprotein convertase subtilisin kexin 9 (PCSK9) gene, comprising an antisense strand having a nucleotide sequence which is less than 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; and methods for treating diseases caused by PCSK9 gene expression by using the pharmaceutical composition.

Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for treating human papilloma virus (HPV) infection. The dsRNA comprises an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an HPV Target gene selected from among HPV E1, HPV E6 and the human E6AP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HPV infection and the expression of the E6AP gene using the pharmaceutical composition; and methods for inhibiting the expression of the HPV Target genes in a cell.

Abstract: A method is provided for selecting membrane-translocating peptides (MTPs) from a peptide display library that are capable of crossing or penetrating a lipid membrane. A plurality of nucleic acid constructs that encode displayed peptides are expressed, resulting in the formation of a plurality of nucleic acid-peptide complexes, each complex comprising at least one displayed peptide associated with the corresponding nucleic acid construct encoding the displayed peptide; the complexes are exposed to a population of membrane-encapsulated compartments, allowing a translocating reaction to occur; complexes that remain unassociated with the membrane are removed; optionally complexes that are associated with the membrane are removed; and internalised nucleic acid-peptide complexes are recovered. The membrane-encapsulated compartments may be artificial vesicles such as liposomes, or populations of one or more cell types.

Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene.

Abstract: The present invention provides methods that are useful for the treatment or prevention of smooth muscle disorders such as urinary incontinence and compounds that are useful in such methods.

Abstract: An inflator includes a distributed charge to be distributed within an inflatable component of an inflatable system and a housing. The housing includes a combustion chamber and a gas storage chamber. The combustion chamber includes an initiator and a gas propellant. The gas storage chamber includes an inert gas at a high pressure. The housing also includes a gas nozzle. The distributed charge is connected to the housing through the gas nozzle. The distributed charge may be mechanically joined to the housing by a ferrule. Upon receiving an electrical signal from a crash sensor or other activator, the initiator ignites the gas propellant in the combustion chamber. The hot gas and hot particles from the burning gas propellant and the initiator flow into the gas storage chamber and heat the compressed inert gas in the gas storage chamber. The heated, compressed gas in the gas storage chamber flows through the gas nozzle and ignites the distributed charge.

Abstract: An inflatable system includes an inflatable component and an distributed charge inflator disposed in the inflatable component. The distributed charge inflator includes a first charge for generating inflating gas and a housing body connected to the first charge. The housing body includes an initiator and a second charge that has relatively long burn time. Upon receiving a signal from a sensor, the initiator ignites the first charge and the second charge simultaneously. The first charge inflates the inflatable component and the second charge sustains the inflation of the inflatable component.

Abstract: An inflatable system includes an inflatable component and an distributed charge inflator disposed in the inflatable component. The distributed charge inflator includes a first charge for generating inflating gas and a housing body connected to the first charge. The housing body includes an initiator and a second charge that has relatively long burn time. Upon receiving a signal from a sensor, the initiator ignites the first charge and the second charge simultaneously. The first charge inflates the inflatable component and the second charge sustains the inflation of the inflatable component.

Abstract: The present invention concerns methods and reagents useful in modulating transcription factor gene expression in a variety of applications, including methods of use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), and doublestranded RNA (dsRNA) molecules capable of mediating RNA interference (RNAi) against E2F1 gene expression, useful in the treatment of cell cycle disorders, inflammatory conditions, reproductive disorders, cancers and any other condition that responds to modulation of E2F1 expression and/or activity.

Abstract: A wheel upon which interchangeable components may be mounted to the change the appearance thereof, is provided. The wheel may include a base wheel skeleton including a rim, a hub and spokes. Each spoke may include threaded holes adjacent the rim. Additional threaded holes may be disposed generally around a periphery of the hub. A hub cap may be attachable to the wheel on a first side of the wheel and include mounting extensions for attachment of the hub cap to the threaded holes around hub. Skin elements may be attachable to the wheel and include holes for attachment of one end of the skin element to one of the threaded holes adjacent the connection of the spokes to the rim. The skin elements may further include an extension disposable under a portion of the hub cap for retention of another end of the skin element by the hub cap.

Abstract: A fishing rod and tackle transport and storage container for a camping unit such as a travel trailer or a camper which is attachable to the underside of a travel trailer or camper. The container has a rod segment with rod tubes and a tackle segment with a tackle enclosure. The rod tubes are connected to the rear wall of the tackle enclosure and open into the tackle enclosure. The tackle enclosure has a lockable access cover.

Abstract: A wheel arrangement is provided which has reinforcing rings adjacent inboard and outboard tire bead seats. The outboard reinforcement ring has a radial width which is substantially greater than the radial width of the inboard reinforcement ring.