Abstract: The present invention relates to Human Immunodeficiency Virus (HIV) prevention and treatment. In particular, the invention relates to a pharmaceutical composition comprising: cabotegravir; a wetting agent; a stabilizer; and a tonicity adjuster; wherein cabotegravir is present in the form of particles having a mass median diameter (X50) of between (and including) 2.5 ?m and 10 ?m.

Abstract: There is provided a seal assembly comprising: a first component and a second component spaced apart from the first component so as to define a passage for the transfer of fluid from an inlet of the seal assembly to an outlet of the seal assembly, wherein the first component comprises a concavity at least partially defining the passage, and wherein no part of the second component extends into the portion of the passage bounded by the concavity.

Abstract: A tubing spool of a wellhead assembly can include a body having a body cavity, a first channel, and a second channel disposed therein, where the body cavity is configured to receive a tubing hanger used to couple to and suspend a tubing string, where the first channel is configured to be in communication with a tubing string cavity within the tubing string, where the second channel is configured to be in communication with an annulus located between the tubing string and a production casing, and where the first channel and the second channel are each configured to facilitate flow of at least one of a plurality of fluids in either direction independently of each other. The tubing spool can also include a first back pressure valve disposed within the first channel and a second back pressure valve disposed within the second channel.

Abstract: A hybrid drive carrier frame includes a front rail comprising a first end, a second end, and a body extending along a transverse direction between the first and second ends. The frame comprises a first side rail extending from the first end of the front rail perpendicular to the transverse direction and a second side rail extending from the second end of the front rail perpendicular to the transverse direction and parallel to the first side rail. The first side rail is formed from a metal material and includes a locking tab extending along the transverse direction. The front and second side rails are formed from a plastic material. The front rail includes a locking channel at the first end of the front rail and the first side rail is connected to the first end of the front rail via engagement of the locking tab within the locking channel.

Abstract: A drive carrier comprises a front portion, a first lateral rail extending from the front portion, and a second lateral rail extending from the front portion. The front portion and first and second lateral rails form a frame configured to receive a media drive between the first and second lateral rails. The first lateral rail is formed from plastic and comprises a screw hole. When the media drive is received in the frame, the media drive is coupled to the first lateral rail by a screw inserted through the screw hole. The drive carrier also has a metal screw plate in-molded into the plastic of the first lateral rail surrounding the screw hole. The screw plate strengthens the first lateral rail around the rim of the screw hole to prevent the head of the screw from cracking the plastic and/or tearing through the plastic.

Abstract: A tubing spool of a wellhead assembly can include a body having a body cavity, a first channel, and a second channel disposed therein, where the body cavity is configured to receive a tubing hanger used to couple to and suspend a tubing string, where the first channel is configured to be in communication with a tubing string cavity within the tubing string, where the second channel is configured to be in communication with an annulus located between the tubing string and a production casing, and where the first channel and the second channel are each configured to facilitate flow of at least one of a plurality of fluids in either direction independently of each other. The tubing spool can also include a first back pressure valve disposed within the first channel and a second back pressure valve disposed within the second channel.

Abstract: A tubing spool of a wellhead assembly can include a body having a body cavity, a first channel, and a second channel disposed therein, where the body cavity is configured to receive a tubing hanger used to couple to and suspend a tubing string, where the first channel is configured to be in communication with a tubing string cavity within the tubing string, where the second channel is configured to be in communication with an annulus located between the tubing string and a production casing, and where the first channel and the second channel are each configured to facilitate flow of at least one of a plurality of fluids in either direction independently of each other. The tubing spool can also include a first back pressure valve disposed within the first channel and a second back pressure valve disposed within the second channel.

Abstract: A magnetic flowmeter assembly is provided having a tubular body, having opposing open ends and defining a fluid flow path therebetween along a longitudinal axis (Ax). A pair of coil assemblies is coupled to the tubular body in an intermediate region thereof supported by an adjustable brace. A pair of measuring electrodes is attached to the tubular body in electrical communication with the fluid with the flow path and aligned along an axis (Ay) orthogonal to the longitudinal axis (Ax) and orthogonal to the axis (Az). Auxiliary electrodes are disposed upstream and downstream of the pair of measuring electrodes.

Abstract: There is provided a seal assembly comprising: a first component and a second component spaced apart from the first component so as to define a passage for the transfer of fluid from an inlet of the seal assembly to an outlet of the seal assembly, wherein the first component comprises a concavity at least partially defining the passage, and wherein no part of the second component extends into the portion of the passage bounded by the concavity.

Abstract: A bioreactor includes a bioreactor container, and a root stand. The container has a base and one or more sidewalls connected to the base, the base and sidewalls together defining an interior bioreactor volume. The root stand is supported by the container within the bioreactor volume, and includes a first support comb and a second support comb, each support comb having a plurality of spaced apart teeth. The teeth of the first support comb extend in length in a first direction and the teeth of the second support comb extend in length in a second direction different from the first direction. The first support comb overlaying the second support comb when the root stand is supported in the container, and the first support comb being separable from the second support comb when the root stand is removed from the container. A gravity well and atmosphere control container are also disclosed.

Abstract: A user interface that facilitates the selection and purchase of an item may be presented on a display. The user interface includes a presentation section and one or more other sections, such as a title section, buy section, alternate image section, package art section, review section, rating section, or other section. The presentation section may extend a full-width of a display or window available for display, while maintaining a desired aspect ratio. Video, slideshows, or other visual information may be played within the presentation section. One or more sections may overlay the presentation section. For example, at least a portion of the buy section may overlay at least a portion of the presentation section.

Abstract: A magnetic flowmeter assembly is provided having electrodes disposed about a tubular body, wherein at least one of the electrodes includes a temperature sensing element inserted therein. The magnetic flowmeter assembly is configured to measure the flow rate of fluid flowing through the tubular body. The temperature sensing element can be inserted within an electrode such that it is well heatsinked to the electrode surface in contact with the fluid flow, thus placing the temperature sensing element in effective thermal contact with the fluid. As such, the magnetic flowmeter assembly enables simultaneous measurement of the fluid flow rate and fluid temperature.

Abstract: A magnetic flowmeter assembly is provided having a tubular body, e.g, formed of plastic material, having opposing open ends and defining a fluid flow path therebetween along a longitudinal axis (Ax). A pair of coil assemblies is coupled to the tubular body in an intermediate region thereof. The pair of coil assemblies is each disposed external to the tubular body on opposing sides of the body aligned along an axis (Az), to generate a magnetic field within the fluid flow path of the tubular body. A pair of measuring electrodes is attached to the tubular body. The pair of electrodes is coupled to a corresponding aperture of the plurality of apertures to be in electrical communication with the fluid with the flow path. The pair of electrodes are aligned along an axis (Ay) orthogonal to the longitudinal axis (Ax) and orthogonal to the axis (Az).

Abstract: Techniques for generating and presenting user interfaces that provide a consolidated representation for same or similar products available for acquisition with variations of product attributes is described. A primary user interface (UI) for presenting a product having a product attribute may be presented via a device. The primary UI may present a representation of the product with an indication that alternate product(s) are available with alternate product attributes. Based on receiving a request to access information about the alternate product(s), a secondary UI may be generated for presenting the information about the alternate product(s). The secondary UI, which may overlay a portion of the primary UI, may be presented via the device. Based on receiving an indication of a selection of an alternate product, the presentation of the secondary UI may be terminated and the primary UI may be updated to reflect the selection of the alternate product.

Abstract: A user interface that facilitates the selection and purchase of an item may be presented on a display. The user interface includes a presentation section and one or more other sections, such as a title section, buy section, alternate image section, package art section, review section, rating section, or other section. The presentation section may extend a full-width of a display or window available for display, while maintaining a desired aspect ratio. Video, slideshows, or other visual information may be played within the presentation section. One or more sections may overlay the presentation section. For example, at least a portion of the buy section may overlay at least a portion of the presentation section.

Abstract: A bioreactor includes a bioreactor container, and a root stand. The container has a base and one or more sidewalls connected to the base, the base and sidewalls together defining an interior bioreactor volume. The root stand is supported by the container within the bioreactor volume, and includes a first support comb and a second support comb, each support comb having a plurality of spaced apart teeth. The teeth of the first support comb extend in length in a first direction and the teeth of the second support comb extend in length in a second direction different from the first direction. The first support comb overlaying the second support comb when the root stand is supported in the container, and the first support comb being separable from the second support comb when the root stand is removed from the container. A gravity well and atmosphere control container are also disclosed.

Abstract: The present disclosure is directed to a planning and navigation method. The planning and navigation method includes obtaining a plurality of images, rendering the plurality of images in three dimensions, automatically segmenting the plurality of images to demarcate a target area, and automatically determining a treatment plan based on the target area. The planning and navigation system also includes obtaining an ultrasound image of a scan plane including the target and obtaining a fiducial image of a fiducial pattern disposed on an ultrasound device using an image capture device on a surgical device. The obtained fiducial image is corrected for lens distortion and a correspondence between the fiducial image and a model image is found. After which a camera pose is a position of the surgical device is transformed to model coordinates.

Abstract: The present disclosure is directed to an ablation planning and navigation system. The planning system includes a memory configured to store a plurality of images and a controller configured to render the plurality of images in three dimensions, automatically segment the plurality of images to demarcate a target area, and automatically determine a treatment plan based on the target area. The navigation system includes an ultrasound device having a fiducial pattern that obtains an ultrasound image, an ablation needle having a image capture device that captures an image of the fiducial pattern, and a controller that receives the ultrasound image and the fiducial image. The controller determines a position of the ablation needle based on the fiducial image. The planning and navigation system also includes a controller that receives data from the planning system and the navigation system and a display configured to display the received information.