Abstract: A vehicle water jacket assembly includes a first water jacket portion establishing a plurality of first fluid channels that are situated to facilitate fluid movement along at least a first plane. A second water jacket portion is situated near the first water jacket portion. The second water jacket portion establishes a plurality of second fluid channels that are situated to facilitate fluid movement along at least a second plane that is generally parallel to the first plane. At least one connector portion establishes a plurality of connector fluid channels that are situated to facilitate fluid movement between at least one of the first fluid channels and at least one of the second fluid channels along a direction that is transverse to the first and second planes.

Abstract: A vehicle water jacket assembly includes a first water jacket portion establishing a plurality of first fluid channels that are situated to facilitate fluid movement along at least a first plane. A second water jacket portion is situated near the first water jacket portion. The second water jacket portion establishes a plurality of second fluid channels that are situated to facilitate fluid movement along at least a second plane that is generally parallel to the first plane. At least one connector portion establishes a plurality of connector fluid channels that are situated to facilitate fluid movement between at least one of the first fluid channels and at least one of the second fluid channels along a direction that is transverse to the first and second planes.

Abstract: The invention relates to compounds, pharmaceutical compositions thereof, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease,

Abstract: The invention relates to substituted adamantane compounds, pharmaceutical compositions thereof, processes for their preparation, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease.

Abstract: The invention includes processes mainly for the treatment of a inflammatory diseases, such as inflammatory bowel disease, arthritis, atherosclerosis, asthma, allergy, inflammatory kidney disease, circulatory shock, multiple sclerosis, chronic obstructive pulmonary disease, skin inflammation, periodontal disease, psoriasis and T cell-mediated diseases of immunity, including allergic encephalomyelitis, allergic neuritis, transplant allograft rejection, graft versus host disease, myocarditis, thyroiditis, nephritis, systemic lupus erthematosus, and insulin-dependent diabetes mellitus. The processes involve treating a patient with a pharmaceutical composition containing an active ingredient that inhibits the activity of sphingosine kinase.

Abstract: The invention includes processes mainly for the treatment of angiogenic diseases, such as diabetic retinopathy, arthritis, cancer, psoriasis, Kaposi's sarcoma, hemangiomas, myocardial angiogenesis, atherosclerosis, and ocular angiogenic diseases such as choroidal neovascularization, retinopathy of prematurity (retrolental fibroplasias), macular degeneration, corneal graft rejection, rubeosis, neuroscular glacoma and Oster Webber syndrome. The processes involve treating a patient with a pharmaceutical composition containing an active ingredient that inhibits the activity of sphingosine kinase.

Abstract: A method for dynamically personalizing transportation in a vehicle comprises the steps of providing a vehicle including a messaging device for displaying messages, providing a central dispatch system for managing passenger allocation to the vehicle, receiving passenger specific information at the dispatch system, providing data relating to the passenger specific information from the dispatch system to the messaging device, and selecting and displaying a message based on the data for display. Further, a method is disclosed in which messages depending on passenger specific information, and messages independent form passenger specific information are selected and displayed. The messaging device is in communication with a video display unit or with a printing device for displaying messages received.

Abstract: A method for dynamically personalizing transportation in a vehicle comprises the steps of providing a vehicle including a messaging device for displaying messages, providing a central dispatch system for managing passenger allocation to the vehicle, receiving passenger specific information at the dispatch system, providing data relating to the passenger specific information from the dispatch system to the messaging device, and selecting and displaying a message based on the data for display. Further, a method is disclosed in which messages depending on passenger specific information, and messages independent form passenger specific information are selected and displayed. The messaging device is in communication with a video display unit or with a printing device for displaying messages received.