Abstract: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-c-Met antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-c-Met antibodies.

Abstract: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-c-Met antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-c-Met antibodies.

Abstract: The present invention provides genes that are differentially expressed during neoplasia. These genes and gene products comprise panels for use in screening candidate agents for therapeutic intervention in lung cancers, and for use in therapeutic, prognostic and diagnostic methods and compositions. Therapeutic agents are also provided by the invention. Diagnostic compositions include compositions comprising detection agents for detecting one or more genes that have been shown to be up-or down-regulated in pathogenesis of lung cancer. Exemplary detection agents include nucleic acid probes, which can be in solution or attached to a solid surface, e.g., in the form of a microarray. The invention also provides computer-readable media comprising values of levels of expression of one or more genes that are modulated in lung cancer.

Abstract: The invention features non-human mammals and animal cells that contain a targeted disruption of an Akt2 gene.

Abstract: Novel peptide and peptide mimetic ligands which act as inhibitors of p34.sup.cdc2 kinase, p33.sup.cdk2 kinase and human papillomavirus transforming protein E7 (HPV E7) are disclosed. The inhibitors are derived from the binding domains of a retinoblastoma tumor suppressor protein (Rb), p107 and a cyclin.

Abstract: A computer security system employs a first telephone line for controlling a security unit which connects a second telephone line to the computer. Each authorized user must have a user security unit generating a control signal, such as an audio signal modulated by a pulse signal having a selectable pulse frequency, pulse duration and/or duration between pulses.

Abstract: A door message apparatus has a control unit which responds to operation of a doorbell switch to connect a door speaker/microphone to an automatic telephone answering and recording machine. The control unit applies a ring signal to the answering machine so that the machine then plays back a prerecorded message which is broadcast to the door caller. After the playback, the door caller may talk into the door speaker/microphone to produce a message which is recorded by the answering machine.

Abstract: An alarm system for an electric range which detects when a burner is energized without a utensil in place on the burner wherein the sensing means comprises an electrical switch mounted below the stovetop having a first switch position and a second switch position, a pin slidably passing through an opening in the stovetop beneath the rim of the dish under the heating element in contact with the underside of the rim and biased against the rim with a pressure sufficient to lift the rim from the stovetop when no utensil is present on the heating element, but insufficient to lift the rim when a utensil is in place on the heating element; and means connecting said pin with the switch to operate the switch between first and second positions corresponding to the position of the pin when a utensil is present or absent from the heating element.