Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: A molten metal processing device including an assembly mounted on the casting wheel, including at least one vibrational energy source which supplies vibrational energy to molten metal cast in the casting wheel while the molten metal in the casting wheel is cooled, and a support device holding the vibrational energy source. An associated method for forming a metal product which provides molten metal into a containment structure included as a part of a casting mill, cools the molten metal in the containment structure, and couples vibrational energy into the molten metal in the containment structure.

Abstract: The disclosure relates to an anti-inflammatory composition containing humate, such as insoluble, granular, other insoluble, or soluble humate, particularly Menefee Humate®. The disclosure also includes other anti-inflammatory compositions containing humate and at least one additional anti-inflammatory agent such as indomethacin or another nonsteroidal anti-inflammatory drug. The disclosure includes a method of treating acute or chronic inflammation in an animal, including a human, by administering one of these compositions. A method of facilitating the therapeutic effect of a therapeutic drug in an animal by co-administering humate is also provided.

Abstract: The invention relates to an anti-inflammatory composition containing humate, such as insoluble, granular, other insoluble, or soluble humate, particularly Menefee Humate®. The invention also includes other anti-inflammatory compositions containing humate and at least one additional anti-inflammatory agent such as indomethacin or another nonsteroidal anti-inflammatory drug. The invention includes a method of treating acute or chronic inflammation in an animal, including a human, by administering one of these compositions. A method of facilitating the therapeutic effect of a therapeutic drug in an animal by co-administering humate is also provided.

Abstract: The invention relates to a novel anti-inflammatory composition containing humate, such as insoluble, granular, other insoluble, or soluble humate, particularly Menefee Humate®. The invention also includes other anti-inflammatory compositions containing humate and at least one additional anti-inflammatory agent such as indomethacin or another nonsteroidal anti-inflammatory drug. The invention includes a method of treating acute or chronic inflammation in an animal, including a human, by administering one of these compositions. A method of facilitating the therapeutic effect of a therapeutic drug in an animal by co-administering humate is also provided.