Abstract: The present invention is directed to a CH3-containing molecule comprising (a) a first polypeptide comprising a CH3 domain and a negatively charged domain comprising consecutive negatively charged amino acid residues; and (b) a second polypeptide comprising a CH3 domain and a positively charged domain comprising consecutive positively charged amino acid residues. Also provided are methods for conjugating synthetic molecules to a multi-specific antigen binding molecule.

Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

Abstract: The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.

Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

Abstract: A staple includes a length of metal wire shaped to form a crown and two spikes. Each spike depends from a respective end of the crown and includes a shoulder at each end of the crown, a sharpened tip portion and an elbow interposed between each tip portion and shoulder, the elbow comprised of a proximal limb and a distal limb such that the tip portions depend from respective distal limbs. An included angle between each shoulder and the crown is between about 91° and 96°, an included angle between each proximal limb and the crown is between about 60° and 85° and an included angle between each distal limb and the crown is between about 95° and 130°.

Abstract: An accessory for a fastening gun includes a magazine assembly with a feed end and a discharge end and configured to support a series of staples in a pre-discharge orientation and with a feed mechanism for feeding the staples from the feed end to the discharge end. A drive member guide assembly is mounted on the magazine assembly and is configured so that a staple drive member can be mounted in the drive member guide assembly and can be driven and retracted along a predetermined path with respect to the magazine assembly, so that, when driven, the drive member can engage a staple to drive legs of the staple into respective components, the drive member guide assembly being configured for mounting on the fastening gun with the drive member connected to a piston or the like of the fastening gun.

Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

Abstract: A detergent pack comprising a plurality of water-soluble unit-dose detergent products the products comprising a detergent composition and an enveloping material the detergent composition comprising: a) a malodour-generating amine-containing cleaning active; and b) a malodour reducing agent comprising a carboxylic functionality. wherein the composition comprises from about 15% to 50% of amine-containing cleaning active.

Abstract: A consumer product composition comprises a non-porous dissolvable solid structure comprising from about 30% to about 95%, by weight of the consumer product composition, of a carrier material, and from about 5% to about 50%, by weight of the consumer product composition, of a hydrophobic conditioning agent disposed within the carrier material of the non-porous dissolvable solid structure. The carrier material comprises a polyethylene glycol material, or mixtures thereof, having a molecular weight of from about 200 to about 50,000. The hydrophobic conditioning agent is selected from the group consisting of silicone materials, organic conditioning oils, hydrocarbon oils, fatty esters, metathesized unsaturated polyol esters, silane-modified oils, and mixtures thereof.

Abstract: A consumer product composition comprises a non-porous dissolvable solid structure comprising a carrier material and at least about 5%, by weight of said consumer product composition, of a hydrophobic conditioning agent disposed within said carrier material.

Abstract: A consumer product composition comprises a non-porous dissolvable solid structure comprising a carrier material and a hydrophobic conditioning agent disposed within the carrier material, wherein the hydrophobic conditioning agent has a mean particle size of from about 2 ?m to about 2000 ?m.

Abstract: A consumer product composition comprises a non-porous dissolvable solid structure comprising a carrier material having a viscosity at 70° C., and a hydrophobic conditioning agent having a viscosity at 70° C. The hydrophobic conditioning agent is disposed within the carrier material of the non-porous dissolvable solid structure. A ratio of the viscosity of the hydrophobic conditioning agent at 70° C. to the viscosity of the carrier material at 70° C. is from about 1000:1 to about 1:1000.

Abstract: A consumer product composition comprises a non-porous dissolvable solid structure comprising from about 30% to about 95%, by weight of the consumer product composition, of a carrier material, and from about 5% to about 50%, by weight of the consumer product composition, of a hydrophobic conditioning agent disposed within the carrier material of the non-porous dissolvable solid structure. The carrier material comprises a polyethylene glycol material, or mixtures thereof, having a molecular weight of from about 200 to about 50,000. The hydrophobic conditioning agent is selected from the group consisting of silicone materials, organic conditioning oils, hydrocarbon oils, fatty esters, metathesized unsaturated polyol esters, silane-modified oils, and mixtures thereof.

Abstract: A consumer product composition comprises a non-porous dissolvable solid structure comprising a carrier material and a hydrophobic conditioning agent disposed within the carrier material, wherein the hydrophobic conditioning agent has a viscosity at 25° C. of at least about 0.01 Pa·s.

Abstract: A process of making a consumer product composition comprising a non-porous dissolvable solid structure comprises the steps of: providing a carrier material having a melting point of greater than 25° C.; heating the carrier material to a temperature greater than the melting point of the carrier material to form liquefied carrier material; mixing a hydrophobic conditioning agent with the liquefied carrier material to form a melt composition; and cooling the melt composition to a temperature below the melting point of the carrier material to form the non-porous dissolvable solid structure of the consumer product composition. The carrier material and hydrophobic conditioning agent are selected to provide a Modified Capillary Number of less than about 10 with respect to the melt composition of the process.

Abstract: A detergent pack comprising a plurality of water-soluble unit-dose detergent products the products comprising a detergent composition and an enveloping material the detergent composition comprising: a) a malodour-generating amine-containing cleaning active; and b) a malodour reducing agent comprising a carboxylic functionality. wherein the composition comprises from about 15% to 50% of amine-containing cleaning active.

Abstract: A staple includes a length of metal wire shaped to form a crown and two spikes. Each spike depends from a respective end of the crown and includes a shoulder at each end of the crown, a sharpened tip portion and an elbow interposed between each tip portion and shoulder, the elbow comprised of a proximal limb and a distal limb such that the tip portions depend from respective distal limbs. An included angle between each shoulder and the crown is between about 91° and 96°, an included angle between each proximal limb and the crown is between about 60° and 85° and an included angle between each distal limb and the crown is between about 95° and 130°.

Abstract: An accessory for a fastening gun includes a magazine assembly with a feed end and a discharge end and configured to support a series of staples in a pre-discharge orientation and with a feed mechanism for feeding the staples from the feed end to the discharge end. A drive member guide assembly is mounted on the magazine assembly and is configured so that a staple drive member can be mounted in the drive member guide assembly and can be driven and retracted along a predetermined path with respect to the magazine assembly, so that, when driven, the drive member can engage a staple to drive legs of the staple into respective components, the drive member guide assembly being configured for mounting on the fastening gun with the drive member connected to a piston or the like of the fastening gun.

Abstract: Technologies are described herein for generating a user interface based on a relational data model. A relational data model may be received. The relational data model may define a plurality of tables including a first table and a second table. The first table may include a first plurality of fields, and the second table may include a second plurality of fields. Relationships between the plurality of tables in the relational data model may be identified. A plurality of forms may be generated based on the relationships as identified. Each of the plurality of forms may correspond to one plurality of tables. The plurality of forms may be linked based on the relationship. The user interface including the plurality of forms as linked may be generated.