Patents by Inventor Kevin Gray
Kevin Gray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240327475Abstract: Proteins, nucleic acids encoding the proteins, compositions comprising the proteins, and methods are provided. The proteins have the ability to be self-targeted to ICAM-1 and, if desired, enzymatically-released at acidic pH. The ICAM-1-targeting peptides are provided as single copies or multiples repeats, and can be separated by linkers from the enzyme segment, from which the ICAM-1 targeting peptides can be released, if desired, at acidic pH. These fusion proteins enhance the activity of the enzyme segment within or liberated from the fusion protein, and provide increased recognition and targeting of diseased organs, transport from the bloodstream across the endothelium into said diseased organ, and intracellular uptake and lysosomal trafficking by cells in them, both in peripheral tissues and the central nervous system. Representative nucleotide and amino acid sequences of these fusion proteins, as well as in vitro, cellular, and in vivo animal data are provided.Type: ApplicationFiled: January 18, 2024Publication date: October 3, 2024Inventors: Silvia Muro, Jing Chen, Melani Solomon, Kevin Gray
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Publication number: 20240286829Abstract: An automated gate actuator system is provided for use in selectively opening and closing a gate that dispenses proppant from a proppant container during the course of a hydraulic fracturing operation. A lever arm is pivotally mounted for movement to place a drive gear in contact with a driven gear to open and close the gate. The gate may be remotely or autonomously actuated in this manner utilizing an electronic control triggered by human and/or sensor input.Type: ApplicationFiled: November 22, 2023Publication date: August 29, 2024Inventors: Marc Kevin Fisher, Brian Dorfman, Kevin Gray, Cory Snyder, Matthew Oehler, Mark John D’Agostino
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Publication number: 20240281614Abstract: Various aspects of the subject technology relate to systems, methods, and machine-readable media for providing open-ended input data and prompting a response to solicit additional information from a user. A method comprises receiving initial input data. The method includes determining a plurality of categories associated with the initial input data; determining for each category in the plurality of categories, a threshold value and a category likeliness score value; and determining a category match between a category and the input data, where the category is one of a plurality of categories, by calculating when the likeliness score value exceeds the threshold value. The method further includes providing a probe request associated with each category match and determining a prediction score associated with each probe request.Type: ApplicationFiled: June 10, 2022Publication date: August 22, 2024Inventors: Kevin GRAY, Julia HEDRICK, Aaron TOPINKA, Brandy STANSELL, Alexandre de SAINT-LEON
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Publication number: 20240094186Abstract: Systems, devices, and methods for localizing magnets are useful for biological tissue analysis and other applications. Tissue analysis systems for use with a tissue analysis device may include a storage medium storing computer readable instructions that cause the execution of magnet localization methods. The system may include the tissue analysis device, which includes a magnet and a magnetometer array disposed adjacent to the magnet. When executed by a processor, the instructions cause operations, including recording a magnetic field of the magnet with the magnetometer array, simulating a simulated magnetic field at each magnetometer of the magnetometer array, and estimating positional information of the magnet based upon iterating simulated positional information of the simulated magnet.Type: ApplicationFiled: February 9, 2023Publication date: March 21, 2024Applicant: Curi Bio, Inc.Inventors: Kevin Gray, Jason Silver
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Patent number: 11912745Abstract: Proteins, nucleic acids encoding the proteins, compositions comprising the proteins, and methods are provided. The proteins have the ability to be self-targeted to ICAM-1 and, if desired, enzymatically-released at acidic pH. The ICAM-1-targeting peptides are provided as single copies or multiples repeats, and can be separated by linkers from the enzyme segment, from which the ICAM-1 targeting peptides can be released, if desired, at acidic pH. These fusion proteins enhance the activity of the enzyme segment within or liberated from the fusion protein, and provide increased recognition and targeting of diseased organs, transport from the bloodstream across the endothelium into said diseased organ, and intracellular uptake and lysosomal trafficking by cells in them, both in peripheral tissues and the central nervous system. Representative nucleotide and amino acid sequences of these fusion proteins, as well as in vitro, cellular, and in vivo animal data are provided.Type: GrantFiled: January 7, 2022Date of Patent: February 27, 2024Assignee: University of Maryland, College ParkInventors: Silvia Muro, Jing Chen, Melani Solomon, Kevin Gray
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Publication number: 20230215223Abstract: A system and method for performing service actions on a vehicle according to a ruleset. The ruleset classifies serviceable conditions of the vehicle according to rules defined within the ruleset. A diagnostic tool is utilized to perform the service actions and is configured to establish data communication with other diagnostic devices that the rules indicate may be required for a certified service action. After the completion of the service actions, certified repair results are generated indicating successful completion of the service action.Type: ApplicationFiled: December 20, 2022Publication date: July 6, 2023Inventors: Matthew Gerald Pasztor, Kevin Gray, James Williams
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Publication number: 20230215222Abstract: A system and method for performing service actions on a vehicle according to a ruleset. The ruleset classifies serviceable conditions of the vehicle according to rules defined within the ruleset. A diagnostic tool is utilized to perform the service actions and is configured to establish data communication with other diagnostic devices that the rules indicate may be required for a certified service action. After the completion of the service actions, certified repair results are generated indicating successful completion of the service action.Type: ApplicationFiled: December 20, 2022Publication date: July 6, 2023Inventors: Matthew Gerald Pasztor, Kevin Gray, Troy Leibl
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Publication number: 20230109347Abstract: Methods and systems for generating three-dimensional (3D) engineered tissues (ETs), and for electrical stimulation of same, are provided. Provided is an ET assembly comprising an ET lid with first post and second post assemblies coupled thereto. Provided is a casting assembly comprising the ET assembly and a casting plate. Provided are stimulation methods and systems for stimulating tissue constructs.Type: ApplicationFiled: February 25, 2021Publication date: April 6, 2023Applicant: CURI BIO, INC.Inventors: Kevin Gray, Samir Kharoufeh, Elliot Fisher, Jason Silver, Nicholas Geisse
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Publication number: 20220204573Abstract: Proteins, nucleic acids encoding the proteins, compositions comprising the proteins, and methods are provided. The proteins have the ability to be self-targeted to ICAM-1 and, if desired, enzymatically-released at acidic pH. The ICAM-1-targeting peptides are provided as single copies or multiples repeats, and can be separated by linkers from the enzyme segment, from which the ICAM-1 targeting peptides can be released, if desired, at acidic pH. These fusion proteins enhance the activity of the enzyme segment within or liberated from the fusion protein, and provide increased recognition and targeting of diseased organs, transport from the bloodstream across the endothelium into said diseased organ, and intracellular uptake and lysosomal trafficking by cells in them, both in peripheral tissues and the central nervous system. Representative nucleotide and amino acid sequences of these fusion proteins, as well as in vitro, cellular, and in vivo animal data are provided.Type: ApplicationFiled: January 7, 2022Publication date: June 30, 2022Inventors: Silvia Muro, Jing Chen, Melani Solomon, Kevin Gray
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Patent number: 11248029Abstract: Proteins, nucleic acids encoding the proteins, compositions comprising the proteins, and methods are provided. The proteins have the ability to be self-targeted to ICAM-1 and, if desired, enzymatically-released at acidic pH. The ICAM-1-targeting peptides are provided as single copies or multiples repeats, and can be separated by linkers from the enzyme segment, from which the ICAM-1 targeting peptides can be released, if desired, at acidic pH. These fusion proteins enhance the activity of the enzyme segment within or liberated from the fusion protein, and provide increased recognition and targeting of diseased organs, transport from the bloodstream across the endothelium into said diseased organ, and intracellular uptake and lysosomal trafficking by cells in them, both in peripheral tissues and the central nervous system. Representative nucleotide and amino acid sequences of these fusion proteins, as well as in vitro, cellular, and in vivo animal data are provided.Type: GrantFiled: November 18, 2020Date of Patent: February 15, 2022Assignee: University of Maryland, College ParkInventors: Silvia Muro, Jing Chen, Melani Solomon, Kevin Gray
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Publication number: 20220021264Abstract: An electric machine is described together with a stator. The electric machine comprises a stator, said stator comprising a cylindrical stator core having an end face; slots provided on the end face, each slot running through the stator core; a plurality of conductor bars disposed within the slots; and an end face assembly electrically connecting at least two of the conductor bars; a rotor having a plurality of magnetic pole pairs; and a controller electrically connected to said stator for regulating an excitation current supplied to or from the conductor bars, wherein the controller regulates an amplitude of the excitation current independently of a frequency of the excitation current. This arrangement simplifies stator construction and allows for optimisation of the electric machine.Type: ApplicationFiled: September 17, 2021Publication date: January 20, 2022Inventors: Bryn Geoffrey Roddick Richards, Luke Read, Kevin Gray, Martin Palmer
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Publication number: 20210270801Abstract: Topographically-guided cell migration devices include a substrate, an ion-permeable surface layer having a unidirectional textured first side, and an electrode pair having interdigitated electrode digits disposed between the substrate and the ion-permeable surface layer. The unidirectional texture of the ion-permeable surface layer is configured to guide migration of a cell culture in a substantially linear migration direction. Other topographically-guided cell migration devices include a substrate, a surface layer having a unidirectional textured first side, and a cell confinement structure with two walls that run substantially parallel to the unidirectional texture in order to guide migration of the cell culture in a substantially linear migration direction.Type: ApplicationFiled: July 2, 2019Publication date: September 2, 2021Applicants: Curi Bio, Inc., University of WashingtonInventors: Deok-Ho KIM, Kevin GRAY, Jongseob CHOI
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Publication number: 20210147495Abstract: Proteins, nucleic acids encoding the proteins, compositions comprising the proteins, and methods are provided. The proteins have the ability to be self-targeted to ICAM-1 and, if desired, enzymatically-released at acidic pH. The ICAM-1-targeting peptides are provided as single copies or multiples repeats, and can be separated by linkers from the enzyme segment, from which the ICAM-1 targeting peptides can be released, if desired, at acidic pH. These fusion proteins enhance the activity of the enzyme segment within or liberated from the fusion protein, and provide increased recognition and targeting of diseased organs, transport from the bloodstream across the endothelium into said diseased organ, and intracellular uptake and lysosomal trafficking by cells in them, both in peripheral tissues and the central nervous system. Representative nucleotide and amino acid sequences of these fusion proteins, as well as in vitro, cellular, and in vivo animal data are provided.Type: ApplicationFiled: November 18, 2020Publication date: May 20, 2021Inventors: Silvia Muro, Jing Chen, Melani Solomon, Kevin Gray
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Publication number: 20200055041Abstract: An apparatus for biological analysis includes a substrate, and an ion-permeable material with a textured surface on a first side of the ion-permeable material. The substrate is disposed proximate to a second side of the ion-permeable material, opposite the first side. A plurality of electrodes is disposed between the substrate and the ion-permeable material, where individual electrodes in the plurality of electrodes are positioned to measure an electrical signal that passes through the ion-permeable material.Type: ApplicationFiled: April 6, 2018Publication date: February 20, 2020Inventors: Deok-Ho KIM, Alec S.T. SMITH, Eunpyo CHOI, Kevin GRAY
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Publication number: 20190229575Abstract: An electric machine is described together with a stator. The electric machine comprises a stator, said stator comprising a cylindrical stator core having an end face; slots provided on the end face, each slot running through the stator core; a plurality of conductor bars disposed within the slots; and an end face assembly electrically connecting at least two of the conductor bars; a rotor having a plurality of magnetic pole pairs; and a controller electrically connected to said stator for regulating an excitation current supplied to or from the conductor bars, wherein the controller regulates an amplitude of the excitation current independently of a frequency of the excitation current. This arrangement simplifies stator construction and allows for optimisation of the electric machine.Type: ApplicationFiled: August 21, 2017Publication date: July 25, 2019Inventors: Bryn Geoffrey Roddick Richards, Luke Read, Kevin Gray, Martin Palmer
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Patent number: 9858731Abstract: A graphical user interface is provided that can be used on a diagnostic tool. The graphical user interface allows a technician to operate various functions of the diagnostic tool including searching for additional information on the Internet, receiving weather information that is relevant to certain diagnostic tests, and displaying in certain formats the retrieved vehicle data and when certain vehicles were last scanned or diagnosed.Type: GrantFiled: July 31, 2013Date of Patent: January 2, 2018Assignee: Bosch Automotive Service Solutions Inc.Inventors: James Fish, David Richard Moulton, Kevin Gray
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Patent number: 9688243Abstract: A system and method for creating and distributing diagnostic tests to diagnostic devices. The system includes user devices, diagnostic devices, diagnostic development system and validation/authentication system. The system can create, validate and distribute one or more diagnostic tests to various diagnostic devices. This allows user to have the latest diagnostic tests in a timely manner.Type: GrantFiled: March 12, 2013Date of Patent: June 27, 2017Assignees: Robert Bosch GmbH, Bosch Automotive Service Solutions Inc.Inventors: Kevin Gray, Matthew Pasztor, William W. Wittliff, III
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Patent number: 9613469Abstract: A graphical user interface is provided that can be used on a diagnostic tool. The graphical user interface allows a technician to operate various functions of the diagnostic tool including searching for additional information on the Internet, receiving weather information that is relevant to certain diagnostic tests, and displaying in certain formats the retrieved vehicle data and when certain vehicles were last scanned or diagnosed.Type: GrantFiled: July 31, 2013Date of Patent: April 4, 2017Assignees: Bosch Automotive Service Solutions Inc., Robert Bosch GmbHInventors: James Fish, David Richard Moulton, Kevin Gray
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Patent number: 9595140Abstract: A graphical user interface is provided that can be used on a diagnostic tool. The graphical user interface allows a technician to operate various functions of the diagnostic tool including searching for additional information on the Internet, receiving weather information that is relevant to certain diagnostic tests, and displaying in certain formats the retrieved vehicle data and when certain vehicles were last scanned or diagnosed.Type: GrantFiled: July 31, 2013Date of Patent: March 14, 2017Assignee: Bosch Automotive Service Solutions Inc.Inventors: James Fish, David Richard Moulton, Kevin Gray
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Patent number: 9563985Abstract: A graphical user interface is provided that can be used on a diagnostic tool. The graphical user interface allows a technician to operate various functions of the diagnostic tool including searching for additional information on the Internet, receiving weather information that is relevant to certain diagnostic tests, and displaying in certain formats the retrieved vehicle data and when certain vehicles were last scanned or diagnosed.Type: GrantFiled: July 31, 2013Date of Patent: February 7, 2017Assignee: Bosch Automotive Service Solutions Inc.Inventors: James Fish, David Richard Moulton, Kevin Gray