Abstract: Proteins, nucleic acids encoding the proteins, compositions comprising the proteins, and methods are provided. The proteins have the ability to be self-targeted to ICAM-1 and, if desired, enzymatically-released at acidic pH. The ICAM-1-targeting peptides are provided as single copies or multiples repeats, and can be separated by linkers from the enzyme segment, from which the ICAM-1 targeting peptides can be released, if desired, at acidic pH. These fusion proteins enhance the activity of the enzyme segment within or liberated from the fusion protein, and provide increased recognition and targeting of diseased organs, transport from the bloodstream across the endothelium into said diseased organ, and intracellular uptake and lysosomal trafficking by cells in them, both in peripheral tissues and the central nervous system. Representative nucleotide and amino acid sequences of these fusion proteins, as well as in vitro, cellular, and in vivo animal data are provided.

Abstract: An automated gate actuator system is provided for use in selectively opening and closing a gate that dispenses proppant from a proppant container during the course of a hydraulic fracturing operation. A lever arm is pivotally mounted for movement to place a drive gear in contact with a driven gear to open and close the gate. The gate may be remotely or autonomously actuated in this manner utilizing an electronic control triggered by human and/or sensor input.

Abstract: Systems, devices, and methods for localizing magnets are useful for biological tissue analysis and other applications. Tissue analysis systems for use with a tissue analysis device may include a storage medium storing computer readable instructions that cause the execution of magnet localization methods. The system may include the tissue analysis device, which includes a magnet and a magnetometer array disposed adjacent to the magnet. When executed by a processor, the instructions cause operations, including recording a magnetic field of the magnet with the magnetometer array, simulating a simulated magnetic field at each magnetometer of the magnetometer array, and estimating positional information of the magnet based upon iterating simulated positional information of the simulated magnet.

Abstract: Proteins, nucleic acids encoding the proteins, compositions comprising the proteins, and methods are provided. The proteins have the ability to be self-targeted to ICAM-1 and, if desired, enzymatically-released at acidic pH. The ICAM-1-targeting peptides are provided as single copies or multiples repeats, and can be separated by linkers from the enzyme segment, from which the ICAM-1 targeting peptides can be released, if desired, at acidic pH. These fusion proteins enhance the activity of the enzyme segment within or liberated from the fusion protein, and provide increased recognition and targeting of diseased organs, transport from the bloodstream across the endothelium into said diseased organ, and intracellular uptake and lysosomal trafficking by cells in them, both in peripheral tissues and the central nervous system. Representative nucleotide and amino acid sequences of these fusion proteins, as well as in vitro, cellular, and in vivo animal data are provided.

Abstract: A system and method for performing service actions on a vehicle according to a ruleset. The ruleset classifies serviceable conditions of the vehicle according to rules defined within the ruleset. A diagnostic tool is utilized to perform the service actions and is configured to establish data communication with other diagnostic devices that the rules indicate may be required for a certified service action. After the completion of the service actions, certified repair results are generated indicating successful completion of the service action.

Abstract: A system and method for performing service actions on a vehicle according to a ruleset. The ruleset classifies serviceable conditions of the vehicle according to rules defined within the ruleset. A diagnostic tool is utilized to perform the service actions and is configured to establish data communication with other diagnostic devices that the rules indicate may be required for a certified service action. After the completion of the service actions, certified repair results are generated indicating successful completion of the service action.

Abstract: Methods and systems for generating three-dimensional (3D) engineered tissues (ETs), and for electrical stimulation of same, are provided. Provided is an ET assembly comprising an ET lid with first post and second post assemblies coupled thereto. Provided is a casting assembly comprising the ET assembly and a casting plate. Provided are stimulation methods and systems for stimulating tissue constructs.

Abstract: Proteins, nucleic acids encoding the proteins, compositions comprising the proteins, and methods are provided. The proteins have the ability to be self-targeted to ICAM-1 and, if desired, enzymatically-released at acidic pH. The ICAM-1-targeting peptides are provided as single copies or multiples repeats, and can be separated by linkers from the enzyme segment, from which the ICAM-1 targeting peptides can be released, if desired, at acidic pH. These fusion proteins enhance the activity of the enzyme segment within or liberated from the fusion protein, and provide increased recognition and targeting of diseased organs, transport from the bloodstream across the endothelium into said diseased organ, and intracellular uptake and lysosomal trafficking by cells in them, both in peripheral tissues and the central nervous system. Representative nucleotide and amino acid sequences of these fusion proteins, as well as in vitro, cellular, and in vivo animal data are provided.

Abstract: Proteins, nucleic acids encoding the proteins, compositions comprising the proteins, and methods are provided. The proteins have the ability to be self-targeted to ICAM-1 and, if desired, enzymatically-released at acidic pH. The ICAM-1-targeting peptides are provided as single copies or multiples repeats, and can be separated by linkers from the enzyme segment, from which the ICAM-1 targeting peptides can be released, if desired, at acidic pH. These fusion proteins enhance the activity of the enzyme segment within or liberated from the fusion protein, and provide increased recognition and targeting of diseased organs, transport from the bloodstream across the endothelium into said diseased organ, and intracellular uptake and lysosomal trafficking by cells in them, both in peripheral tissues and the central nervous system. Representative nucleotide and amino acid sequences of these fusion proteins, as well as in vitro, cellular, and in vivo animal data are provided.

Abstract: An electric machine is described together with a stator. The electric machine comprises a stator, said stator comprising a cylindrical stator core having an end face; slots provided on the end face, each slot running through the stator core; a plurality of conductor bars disposed within the slots; and an end face assembly electrically connecting at least two of the conductor bars; a rotor having a plurality of magnetic pole pairs; and a controller electrically connected to said stator for regulating an excitation current supplied to or from the conductor bars, wherein the controller regulates an amplitude of the excitation current independently of a frequency of the excitation current. This arrangement simplifies stator construction and allows for optimisation of the electric machine.

Abstract: Proteins, nucleic acids encoding the proteins, compositions comprising the proteins, and methods are provided. The proteins have the ability to be self-targeted to ICAM-1 and, if desired, enzymatically-released at acidic pH. The ICAM-1-targeting peptides are provided as single copies or multiples repeats, and can be separated by linkers from the enzyme segment, from which the ICAM-1 targeting peptides can be released, if desired, at acidic pH. These fusion proteins enhance the activity of the enzyme segment within or liberated from the fusion protein, and provide increased recognition and targeting of diseased organs, transport from the bloodstream across the endothelium into said diseased organ, and intracellular uptake and lysosomal trafficking by cells in them, both in peripheral tissues and the central nervous system. Representative nucleotide and amino acid sequences of these fusion proteins, as well as in vitro, cellular, and in vivo animal data are provided.

Abstract: An electric machine is described together with a stator. The electric machine comprises a stator, said stator comprising a cylindrical stator core having an end face; slots provided on the end face, each slot running through the stator core; a plurality of conductor bars disposed within the slots; and an end face assembly electrically connecting at least two of the conductor bars; a rotor having a plurality of magnetic pole pairs; and a controller electrically connected to said stator for regulating an excitation current supplied to or from the conductor bars, wherein the controller regulates an amplitude of the excitation current independently of a frequency of the excitation current. This arrangement simplifies stator construction and allows for optimisation of the electric machine.

Abstract: A graphical user interface is provided that can be used on a diagnostic tool. The graphical user interface allows a technician to operate various functions of the diagnostic tool including searching for additional information on the Internet, receiving weather information that is relevant to certain diagnostic tests, and displaying in certain formats the retrieved vehicle data and when certain vehicles were last scanned or diagnosed.

Abstract: A system and method for creating and distributing diagnostic tests to diagnostic devices. The system includes user devices, diagnostic devices, diagnostic development system and validation/authentication system. The system can create, validate and distribute one or more diagnostic tests to various diagnostic devices. This allows user to have the latest diagnostic tests in a timely manner.

Abstract: A graphical user interface is provided that can be used on a diagnostic tool. The graphical user interface allows a technician to operate various functions of the diagnostic tool including searching for additional information on the Internet, receiving weather information that is relevant to certain diagnostic tests, and displaying in certain formats the retrieved vehicle data and when certain vehicles were last scanned or diagnosed.

Abstract: A graphical user interface is provided that can be used on a diagnostic tool. The graphical user interface allows a technician to operate various functions of the diagnostic tool including searching for additional information on the Internet, receiving weather information that is relevant to certain diagnostic tests, and displaying in certain formats the retrieved vehicle data and when certain vehicles were last scanned or diagnosed.

Abstract: A graphical user interface is provided that can be used on a diagnostic tool. The graphical user interface allows a technician to operate various functions of the diagnostic tool including searching for additional information on the Internet, receiving weather information that is relevant to certain diagnostic tests, and displaying in certain formats the retrieved vehicle data and when certain vehicles were last scanned or diagnosed.

Abstract: A graphical user interface that is capable of being used on a computing device, such as a vehicle diagnostic tool. The graphical user interface includes various buttons that when actuated causes the vehicle diagnostic tool to perform a corresponding functionality such as read diagnostic trouble codes and collect and display a data stream of diagnostic data of a vehicle. The graphical user interface also displays buffered data in a data window and the data may be moved using various input buttons.