Patents by Inventor Kevin H. Hazen

Kevin H. Hazen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9766126
    Abstract: An analyzer apparatus and method of use thereof is described to dynamically irradiate a sample with incident light where the incident light is varied in time in terms of any of: position, radial position relative to a point of the skin of a subject, solid angle, incident angle, depth of focus, energy, and/or intensity. For example, the incident light is varied in radial position as a function of time relative to one or more of a sample site, a point on skin of the subject, a detection optic, and/or a sample volume observed by a detection system. The radially varied incident light is used to enhance and/or vary light probing the epidermis, the dermis, and/or the subcutaneous fat of the subject or of a group of subjects.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: September 19, 2017
    Assignee: Zyomed Corp.
    Inventors: Sandeep Gulati, Thomas George, Timothy L. Ruchti, Alan Abul-Haj, Kevin H. Hazen
  • Publication number: 20160249836
    Abstract: A noninvasive analyzer apparatus and method of use thereof is described for spatially separating light for use in noninvasively determining an analyte concentration of a subject through use of detectors linked to multiple controlled sample illumination zone to sample detection zone distances. The controlled radial separation of illumination and detection zones yields reduced deviation in total observed optical pathlength and/or control of pathlengths in a desired tissue volume for each element of a set of detector elements. Performance using the discrete detection zones is enhanced using a combination of segmented spacers, arcs of detector elements, use of micro-optics, use of optical filters associated with individual detector elements, control of detector response shapes, and/or outlier analysis achievable through use of multiple separate and related observed signals of a detector array.
    Type: Application
    Filed: December 10, 2015
    Publication date: September 1, 2016
    Inventors: Sandeep Gulati, Timothy Ruchti, Kevin H. Hazen
  • Publication number: 20160242682
    Abstract: A noninvasive analyzer apparatus and method of use thereof is described for spatially separating light having noninvasively probed a tissue volume into groups, which narrows standard deviations of probed tissue pathlength for each of the groups. Reduction in tissue pathlength uncertainty subsequently enhances noninvasive analyte concentration determination accuracy. Control of individual detector distance from an illumination zone in combination with control of area of a detection zone coupled to an individual detector yields intensity control of the various groups.
    Type: Application
    Filed: December 10, 2015
    Publication date: August 25, 2016
    Inventors: Sandeep Gulati, Timothy Ruchti, Kevin H. Hazen
  • Publication number: 20150045636
    Abstract: A noninvasive analyzer apparatus and method of use thereof is described using a plurality of time resolved sample illumination zones coupled to at least one two-dimensional detector array monitoring a plurality of detection zones. Control of illumination times and/or patterns along with selected detection zones yields pathlength resolved groups of spectra. Sectioned pixels and/or zones of the detector are optionally filtered for different light throughput as a function of wavelength. The pathlength resolved groups of spectra are subsequently analyzed to determine an analyte property. Optionally, in the mapping and/or collection phase, incident light is controllably varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, intensity, and/or detection angle. Optionally, one or more physiological property and/or model property related to a physiological property is used in the analyte property determination.
    Type: Application
    Filed: August 9, 2013
    Publication date: February 12, 2015
    Inventors: Vlad Novotny, Sandeep Gulati, Thomas George, Timothy Ruchti, Alan Abul-Haj, Kevin H. Hazen
  • Publication number: 20150041656
    Abstract: A noninvasive analyzer apparatus and method of use thereof is described using a plurality of time resolved sample illumination zones coupled to at least one two-dimensional detector array monitoring a plurality of detection zones. Control of illumination times and/or patterns along with selected detection zones yields pathlength resolved groups of spectra. Sectioned pixels and/or zones of the detector are optionally filtered for different light throughput as a function of wavelength. The pathlength resolved groups of spectra are subsequently analyzed to determine an analyte property. Optionally, in the mapping and/or collection phase, incident light is controllably varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, intensity, and/or detection angle. Optionally, one or more physiological property and/or model property related to a physiological property is used in the analyte property determination.
    Type: Application
    Filed: August 9, 2013
    Publication date: February 12, 2015
    Inventors: Vlad Novotny, Sandeep Gulati, Thomas George, Timothy Ruchti, Alan Abul-Haj, Kevin H. Hazen
  • Publication number: 20150018642
    Abstract: An analyzer apparatus and method of use thereof is configured to dynamically interrogate a sample. For example, an analyzer using light interrogates a tissue sample using a temporal resolution system on a time scale of less than about one hundred nanoseconds. Optionally, near-infrared photons are introduced to a sample with a known illumination zone to detection zone distance allowing calculation of parameters related to photon pathlength in tissue and/or molar absorptivity of an individual or group through the use of the speed of light and/or one or more indices of refraction. Optionally, more accurate estimation of tissue properties are achieved through use of: knowledge of incident photon angle relative to skin, angularly resolved detector positions, anisotropy, skin temperature, environmental information, information related to contact pressure, blood glucose concentration history, and/or a skin layer thickness, such as that of the epidermis and dermis.
    Type: Application
    Filed: July 12, 2013
    Publication date: January 15, 2015
    Inventors: Sandeep Gulati, Thomas George, Timothy Ruchti, Alan Abul-Haj, Kevin H. Hazen
  • Publication number: 20150018646
    Abstract: A noninvasive analyzer apparatus and method of use thereof is described using a sample mapping phase to establish one or more analyzer/software parameters used in a subsequent individual and/or group specific data collection phase. For example, in the sample mapping phase distance between incident and collected light is varied as a function of time for collected noninvasive spectra. Spectra collected in the sample mapping phase are analyzed to determine a physiological property of the subject, such as dermal thickness, hydration, collagen density, epidermal thickness, and/or subcutaneous fat depth. Using the physiological property or measure thereof, the analyzer is optically reconfigured for the individual to yield subsequent spectra having enhanced features for noninvasive analyte property determination.
    Type: Application
    Filed: July 12, 2013
    Publication date: January 15, 2015
    Inventors: Sandeep Gulati, Thomas George, Timothy Ruchti, Alan Abul-Haj, Kevin H. Hazen
  • Publication number: 20150015888
    Abstract: An analyzer apparatus and method of use thereof is described to dynamically irradiate a sample with incident light where the incident light is varied in time in terms of any of: position, radial position relative to a point of the skin of a subject, solid angle, incident angle, depth of focus, energy, and/or intensity. For example, the incident light is varied in radial position as a function of time relative to one or more of a sample site, a point on skin of the subject, a detection optic, and/or a sample volume observed by a detection system. The radially varied incident light is used to enhance and/or vary light probing the epidermis, the dermis, and/or the subcutaneous fat of the subject or of a group of subjects.
    Type: Application
    Filed: July 12, 2013
    Publication date: January 15, 2015
    Inventors: Sandeep Gulati, Thomas George, Timothy Ruchti, Alan Abul-Haj, Kevin H. Hazen
  • Patent number: 8504128
    Abstract: Sampling is controlled in order to enhance analyte concentration estimation derived from noninvasive sampling. More particularly, sampling is controlled using controlled fluid delivery to a region between a tip of a sample probe and a tissue measurement site. The controlled fluid delivery enhances coverage of a skin sample site with the thin layer of fluid. Delivery of contact fluid is controlled in terms of spatial delivery, volume, thickness, distribution, temperature, and/or pressure.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: August 6, 2013
    Assignee: GLT Acquisition Corp.
    Inventors: Thomas B. Blank, Stephen L. Monfre, Kevin H. Hazen, Timothy L. Ruchti, Christopher Slawinski, Sedar R. Brown
  • Patent number: 7787924
    Abstract: The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.
    Type: Grant
    Filed: January 3, 2006
    Date of Patent: August 31, 2010
    Assignee: Sensys Medical, Inc.
    Inventors: George M. Acosta, James R. Henderson, N. Alan Abul Haj, Timothy L. Ruchti, Stephen L. Monfre, Thomas B. Blank, Kevin H. Hazen
  • Patent number: 7751192
    Abstract: A heatsink having tapered geometry that improves passive cooling efficiency is discussed. A tapered geometry between heatsink heat dissipation elements, as a function of distance along a z-axis opposing gravity, decreases resistance to rarification of passively flowing cooling gas upon heating. Thus, the tapered heatsink elements result in higher velocity of gas flow and increased cooling efficiency of the heatsink. Optionally, the heatsink is made from a thermally conductive polymer allowing the heatsink to be created in complex shapes using injection molding.
    Type: Grant
    Filed: August 9, 2007
    Date of Patent: July 6, 2010
    Assignee: Sensys Medical, Inc.
    Inventors: Roxanne E. Abul-Haj, N. Alan Abul-Haj, Timothy W. Stippick, Kevin H. Hazen
  • Patent number: 7697966
    Abstract: The invention provides a targeting system used to direct a measuring system to a targeted sample site or volume. The targeting system increases analyte estimation performance by increasing precision and accuracy of sampling and/or by targeting an analyte rich tissue volume.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: April 13, 2010
    Assignee: Sensys Medical, Inc.
    Inventors: Stephen L. Monfre, Thomas B. Blank, Kevin H. Hazen, Alan Abul-Haj, Tim Ruchti, James Ryan Henderson, Tim Stippick, Roxanne Abul-Haj
  • Patent number: 7698105
    Abstract: The invention relates to noninvasive analyte property determination. More particularly, the invention relates to a method and apparatus for performing conditional additional acquisition of noninvasive spectra to improve analyzer performance. Conditional additional data acquisition is used to confirm, update, and/or supplement spectral data.
    Type: Grant
    Filed: June 27, 2005
    Date of Patent: April 13, 2010
    Assignee: Sensys Medical, Inc.
    Inventors: Timothy L. Ruchti, Linda Hockersmith, Stephen L. Monfre, Kevin H. Hazen
  • Publication number: 20090318786
    Abstract: Sampling is controlled in order to enhance analyte concentration estimation derived from noninvasive sampling. More particularly, sampling is controlled using controlled fluid delivery to a region between a tip of a sample probe and a tissue measurement site. The controlled fluid delivery enhances coverage of a skin sample site with the thin layer of fluid. Delivery of contact fluid is controlled in terms of spatial delivery, volume, thickness, distribution, temperature, and/or pressure.
    Type: Application
    Filed: April 25, 2008
    Publication date: December 24, 2009
    Inventors: Thomas B. BLANK, Timothy L. RUCHTI, Stephen L. MONFRE, Kevin H. HAZEN, Sedar BROWN, Christopher SLAWINSKI
  • Patent number: 7620674
    Abstract: The invention comprises transformation of a section of a data block independently of the transformation of separate or overlapping data blocks to determine a property related to the original matrix, where each of the separate or overlapping data blocks are derived from an original data matrix. The transformation enhances parameters of a first data block over a given region of an axis of the data matrix, such as signal-to-noise, without affecting analysis of a second data block derived from the data matrix. This allows for enhancement of analysis of an analyte property, such as concentration, represented within the original data matrix. A separate decomposition and factor selection for each selected data matrix is performed with subsequent score matrix concatenization. The combined score matrix is used to generate a model that is subsequently used to estimate a property, such as concentration represented in the original data matrix.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: November 17, 2009
    Assignee: Sensys Medical, Inc.
    Inventors: Timothy L. Ruchti, Alexander D. Lorenz, Kevin H. Hazen
  • Patent number: 7606608
    Abstract: An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.
    Type: Grant
    Filed: December 8, 2004
    Date of Patent: October 20, 2009
    Assignee: Sensys Medical, Inc.
    Inventors: Thomas B. Blank, George Acosta, Mutua Mattu, Marcy Makarewicz, Stephen L. Monfre, Alexander D. Lorenz, Timothy L. Ruchti, Kevin H. Hazen, Donovan D. Berry, Roxanne E. Abul-Haj
  • Patent number: 7593230
    Abstract: The invention relates to a heatsink. More particularly, the invention relates to a heatsink having tapered geometry that improves passive cooling efficiency. A tapered geometry between heatsink heat dissipation elements, as a function of distance along a z-axis opposing gravity, decreases resistance to rarification of passively flowing cooling gas upon heating. Thus, the tapered heatsink elements result in higher velocity of gas flow and increased cooling efficiency of the heatsink. Optionally, the heatsink is made from a thermally conductive polymer allowing the heatsink to be created in complex shapes using injection molding.
    Type: Grant
    Filed: July 14, 2005
    Date of Patent: September 22, 2009
    Assignee: Sensys Medical, Inc.
    Inventors: Roxanne E. Abul-Haj, N. Alan Abul-Haj, Timothy W. Stippick, Kevin H. Hazen
  • Publication number: 20090098587
    Abstract: A method of screening for disorders of glucose metabolism such as impaired glucose tolerance and diabetes allows prevention, or early detection and treatment of diabetic complications such as cardiovascular disease, retinopathy, and other disorders of the major organs and systems. A mathematical algorithm evaluates the shape of a subject's glucose profile and classifies the profile into one of several predefined clusters, each cluster corresponding either to a normal condition or one of several abnormal conditions. The series of blood glucose values making up the glucose tolerance curve may be measured using any glucose analyzer including: invasive, minimally invasive and noninvasive types. The method is executed on a processing device programmed to perform the steps of the method. Depending on the outcome of the screening, a subject may be provided with additional information concerning their condition and/or counseled to consult further with their health care provider.
    Type: Application
    Filed: April 8, 2008
    Publication date: April 16, 2009
    Applicant: SENSYS MEDICAL, INC.
    Inventors: Donald Hetzel, Stephen L. Monfre, Kevin H. Hazen, Timothy L. Ruchti, Thomas B. Blank, Linda Hockersmith, Andrew Cone
  • Patent number: 7519406
    Abstract: A method and apparatus are provided for noninvasive sampling. More particularly, the method and apparatus relate to control of motion of an optical sample probe interface relative to a tissue sample site. A dynamic probe interface, is used to collect spectra of a targeted sample, control positioning of the sample probe relative to the tissue sample in terms of at least one of x-, y-, and z-axes, and/or control of sample tissue displacement to minimize spectral variations resulting from the sampling process and increase analyte property estimation precision and accuracy.
    Type: Grant
    Filed: April 27, 2005
    Date of Patent: April 14, 2009
    Assignee: Sensys Medical, Inc.
    Inventors: Thomas B. Blank, George M. Acosta, Timothy L. Ruchti, Mutua Mattu, Alexander D. Lorenz, Kevin H. Hazen, James R. Henderson
  • Patent number: 7505801
    Abstract: A placement guide apparatus with an improved hydration inducing plug used in coupling a noninvasive analyzer to a sampling site to determine analyte in the human body is disclosed. The hydration inducing plug includes at least one fluoropolymer that may be used as a coupling agent. The guide apparatus may further include an automated or semi-automated coupling fluid delivery system. Use of either of these couplers mitigates issues associated with related technology and enhances noninvasive analyte measurements, such as a near-IR diffuse reflectance based noninvasive glucose concentration analyzer.
    Type: Grant
    Filed: August 30, 2007
    Date of Patent: March 17, 2009
    Assignee: Sensys Medical, Inc.
    Inventors: Stephen L. Monfre, George M. Acosta, Thomas B. Blank, Kevin H. Hazen