Abstract: The present invention relates generally to a mathematical and computer model of diabetes related disorders (e.g., human type 2 diabetes) within the framework of multiple macronutrient metabolism. The model includes a representation of complex physiological control mechanisms directing, for example, fat metabolism, protein metabolism and/or carbohydrate metabolism. In one embodiment, for example, the model can account for the interconversion between macronutrients, as well as their digestion, absorption, storage, mobilization, and adaptive utilization, as well as the endocrine control of these processes. In this embodiment, the model can simulate, for example, a heterogeneous group of diabetes related disorders, from insulin resistant to severe diabetic, and can predict the likely effects of therapeutic interventions.

Abstract: Apparatus (1) and process for the manufacture of lollipops in which lollipops (3) are transferred from a substantially horizontal condition in a hopper (4), to a substantially vertical condition in a stick retainer (7) prior to placement in sugar confectionery. The apparatus comprises a hopper (4) for holding the sticks (3) with their longitudinal axes substantially horizontal, means (5) for ejecting a stick from the hopper in a substantially horizontal direction and feeder means (6) for feeding the ejected stick downwardly into a stick retainer (7) prior to placement in the sugar confectionery, the feeder means comprising a flexible tube (8) operable to conduct the stick from the hopper to the stick retainer whilst simultaneously changing the orientation at the stick to that of a downward direction.

Abstract: Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected subset of cells obtained from the biological sample are described. A set of chromosomal probes and kits for detecting cancer that include sets of chromosomal probes, are also described.

Abstract: Generally, the present invention (referred to also as the “suspension system”) is incorporated in a system for suspending an HVAC unit from one or more wood truss members through the use of one or more top lock plates connected to the wood truss, one or more bottom lock plates connected to the HVAC unit, and one or more suspension chains connected between the top lock plates and the bottom lock plates. The suspension system provides a system for suspending HVAC equipment in residential and light commercial applications that is safer, quicker, cheaper, more reliable and more accurate than systems currently in use.

Abstract: A digital apparatus having a cable comprising a plurality of high-speed and low-speed signal carrying conductors, the conductors carrying the low-speed signals are bypassed to a signal ground with selected values of capacitance so as to become virtual signal ground return conductors for the high-speed signal conductors. The selected values of capacitance have a lower impedance then the characteristic impedance of the conductors in the cable. The cable may be a multi conductor cable, a ribbon cable, a flex cable, a twisted pair cable, etc. In a similar fashion, signal conductors on a printed circuit board, not having a separate ground plane layer, may create virtual signal ground returns from the low-speed signal carrying conductors that are proximate to the high-speed signal carrying conductors for reduction of radiated electromagnetic radio frequency interference.

Abstract: The present invention describes a process for the production of ethanol by harvesting starch-accumulating filament-forming or colony-forming algae to form a biomass, initiating cellular decay of the biomass, fermenting the biomass in the presence of a yeast, and the isolating the ethanol produced. The present invention further relates to processing of the biomass remaining after ethanol production to recovering biodiesel starting materials and/or generation of heat and carbon dioxide via combustion.

Abstract: Nucleic acids and methods for amplifying and detecting mutant BRAF sequences are provided herein. In particular, nucleic acids and methods for amplifying and detecting BRAF sequences that encode the V600E BRAF mutant are provided herein.

Abstract: A marking sphere dispensing apparatus for dispensing fluid-assisted marking spheres into pavement marking materials applied to a surface has a frame defining a marking sphere receptacle having a valve seat defining an opening between the marking sphere receptacle and an expulsion duct. A plunger is disposed coaxially to the longitudinal axis of the dispensing apparatus and defines an internal fluid passage for providing pressurized fluid. The plunger is moveable in a longitudinal direction within the marking sphere dispensing frame between a first position at which a plunger head of the plunger is seated against the valve seat to close the opening, and a second position at which the plunger head is axially offset from the valve seat to define a marking sphere inlet gap across the opening. A method for apply marking spheres uses the marking sphere dispensing apparatus.

Abstract: Probe sets and methods of using probes and probe sets for selectively detecting high grade dysplasia and esophageal adenocarcinoma or low grade dysplasia from biologic samples are described. Methods of the invention include contacting a biological sample obtained from a subject with a set of chromosomal probes to selectively detect an esophageal carcinoma or precursor lesion in the sample, if any, under conditions for specifically hybridizing the probes to their nucleic targets present in the sample. The presence or absence of high grade dysplasia and esophageal adenocarcinoma or low grade dysplasia is thereafter specifically determined from the hybridization pattern detected for the set of chromosomal probes to the biological sample.

Abstract: Probe sets and methods of using probes and probe sets for the detection of cancer are described. Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if cancer cells are present the sample. Also included are methods of selecting a combination of probes for the detection of cancer.

Abstract: A special effects device is disclosed having a transparent, flexible, static cling backing for removable attachment to glass or other smooth surfaces, a shatter object attached to the backing, and a shatter pattern imprinted on the backing. When attached to a surface such as glass or plastic, the device gives the visual effect of the shatter object having broken and partially penetrated the surface. A message, logo, or other alphanumeric identification can be imprinted on the shatter object for advertising purposes.

Abstract: Apparatus and methods for assessing metabolic substrate utilization are described. In one embodiment, a processor-readable medium includes code to receive data indicative of a plasma glucose concentration, a plasma free fatty acid concentration, and a respiratory quotient of a subject. The processor-readable medium also includes code to calculate, based on the data, respective values of a set of metabolic parameters. The set of metabolic parameters includes a first metabolic parameter and a second metabolic parameter. The value of the first metabolic parameter is indicative of whether the subject has a predisposition towards oxidation of a first type of metabolic substrate or a second type of metabolic substrate, and the value of the second metabolic parameter is indicative of the subject's responsiveness to a change in availability of the first type of metabolic substrate or the second type of metabolic substrate.

Abstract: An assembly and method for distributing lollipop sticks (9) from a common supply (5) to a plurality of stick holders (14), the assembly comprising an elongated conveyor chamber (3) for containing lollipop sticks as they are conveyed from the common supply to the stick holders, a plurality of stick holding channels, (14) spaced apart and leading from the base of the chamber, the conveyor chamber containing basal surfaces (11), (13) operative to move in each of two substantially opposite directions, and in use the base supporting a plurality of lollipop sticks, the basal surfaces comprising a first basal surface portion (11) and a second basal surface portion (13), the first basal surface portion (11) being obstructive to sticks in contact with the first basal surface portion as said first basal surface portion moves in a first direction away from the common supply (5), and the second basal surface portion (13) being relatively less obstructive to sticks in contact with said second basal surface portion (13) wh

Abstract: Apparatus (1) and process for the manufacture of lollipops in which lollipops (3) are transferred from a substantially horizontal condition in a hopper (4), to a substantially vertical condition in a stick retainer (7) prior to placement in sugar confectionery. The apparatus comprises a hopper (4) for holding the sticks (3) with their longitudinal axes substantially horizontal, means (5) for ejecting a stick from the hopper in a substantially horizontal direction and feeder means (6) for feeding the ejected stick downwardly into a stick retainer (7) prior to placement in the sugar confectionery, the feeder means comprising a flexible tube (8) operable to conduct the stick from the hopper to the stick retainer whilst simultaneously changing the orientation at the stick to that of a downward direction.

Abstract: For EMI reduction the current modulation profile is preferably used for frequencies over 1 GHz while the frequency deviation is increased at least to ±2.5 MHz and the modulation frequency is increased to at least 150 kHz, preferably about 260 kHz. In an alternative embodiment, the modification frequency is 1 MHz or greater so that a segmented spectrum is achieved. For clocks having basic frequency below 1 GHz, but having strong harmonics higher than 1 GHz, modulation of the foregoing is combined with the slower modulation currently used. EMI reduction is realized both at the lower and the higher harmonics.

Abstract: A method of manufacturing an ophthalmic lens, involves contacting the lens with an aqueous solution comprising a surfactant to remove debris from the lens, prior to inspecting and packaging the lens. The aqueous solution may further comprise a buffering agent and/or sodium chloride. Preferred surfactants include polyoxyethylene-polyoxypropylene block copolymer, nonionic surfactants, such as a poloxamer or a poloxamine. The methods may also be employed for additional biomedical devices, such as ophthalmic implants.

Abstract: A double door assembly having an active door and a passive door includes an astragal that is formed of a composite of aluminum and wood. The astragal is formed of an aluminum rail with a U-shaped cross section that receives a wooden insert. The astragal is mounted to a passive door such that the U-shaped cross section opens to the active door and the wooden insert presents a mounting surface for hardware.

Abstract: A special effects device is disclosed having a transparent, flexible, static-cling backing for removable attachment to glass or other smooth surfaces, a shatter object attached to the backing, and a shatter pattern imprinted on the backing. When attached to a surface such as glass or plastic, the device gives the visual effect of the shatter object having broken and partially penetrated the surface. A message, logo, or other alphanumeric identification can be imprinted on the shatter object for advertising purposes.

Abstract: The present invention relates generally to a mathematical and computer model of diabetes related disorders (e.g., human type 2 diabetes) within the framework of multiple macronutrient metabolism. The model includes a representation of complex physiological control mechanisms directing, for example, fat metabolism, protein metabolism and/or carbohydrate metabolism. In one embodiment, for example, the model can account for the interconversion between macronutrients, as well as their digestion, absorption, storage, mobilization, and adaptive utilization, as well as the endocrine control of these processes. In this embodiment, the model can simulate, for example, a heterogeneous group of diabetes related disorders, from insulin resistant to severe diabetic, and can predict the likely effects of therapeutic interventions.

Abstract: A wheel end is provided where the spindle is an integral cast and machined trumpet-shaped arm made from high strength ductile iron, and a seal retainer is provided to locate and protect the inner wheel bearing and wheel end from debris. The trumpet-shaped arm is formed with a long parabolic radius machined with a reasonable surface finish to reduce or significantly eliminate stress concentrations. The mating cast iron seal retainer is employed to provide proper location for the inner wheel bearing and to transfer axial loads of the bearing to the spindle shoulder. In addition, the seal retainer retains the inner half of the seal face and provides a sealing surface to prevent escape of the axle wheel end oil. In this design, the outside diameter of the seal retainer is made to fit inside the wheel hub bore where it is protected from rocks, stumps, other debris, etc.