Abstract: An intravenous drug access system. In one embodiment of the invention, the drug access system includes an IV bag having an inlet port and outlet port, whereby the inlet port is a female luer integral therewith. The integral female luer fitting may be fitted with a sealed end cap comprising a male luer insert with a closed end. An alternative embodiment of the present invention comprises a discrete pre-molded connector made with one spike at one end and a female luer fitting at the opposing end. The spike is used to penetrate a standard IV bag through a conventional inlet port.