Abstract: A method for determining a zeitgeber, K(t), for use in a circadian entrainment system to entrain an individual's circadian clock from a current circadian trajectory, x(t), towards a target circadian trajectory, y(t), can reduce a cost function C=C(x(t), y(t), K(t)) given an initial circadian state, x0, and y(t), by (a) providing an initial zeitgeber, K0(t), setting K(t)=K0(t), (b) simulating x(t) in response to K0(t), (c) computing a global cost function, C(x(t), y(t), K0(t)), based on the simulation, (d) determining whether the global cost function meets a set of convergence criteria, and if not, (e) updating K(t) based on the global cost function, (f) updating the global cost function based on the updated zeitgeber K(t), (g) iterating until the global cost function meets the convergence criteria, and (h) providing the updated zeitgeber K(t) for use in the circadian entrainment system to entrain the individual's circadian clock.

Abstract: A method of extracting event information from calendar representations is provided. A calendar representation can be determined from an image of a calendar or schedule. A circadian state of a person might be determined by obtaining user data over a plurality of days, determining, for each of at least a subset of the plurality of days, an event type for each day, determining a circadian trajectory for a past day of the plurality of days, estimating a circadian trajectory and/or a circadian state for a future day and a mapping of the circadian trajectory and/or the circadian state to wall-clock time, and using the mapping to determine when to initiate or announce a biological treatment for the person based on a preference of circadian state for the biological treatment.

Abstract: A method of treatment and/or a treatment plan for administering a substance to a patient or performing a procedure on the patient can be timed using a modified scheduling process, implemented typically as a computer process, wherein a nonlinear treatment mapping is based on circadian trajectories computed from patient-specific inputs and uncertainty ranges.

Abstract: A goal of this invention is to minimize the cost of shifting a circadian state or entraining a state to a target cycle by identifying a preferred zeitgeber stimulus. Another goal of this invention is to provide a method to determine a person's circadian state trajectory given a stimulus time series.