Abstract: Anti-PSMA antibodies (e.g., UniAbs™) and CAR-T structures are disclosed, along with methods of making such antibodies and CAR-T structures, compositions, including pharmaceutical compositions, comprising such antibodies and CAR-T structures, and their use to treat disorders that are characterized by the expression of PSMA.

Abstract: The present invention relates to an intranasal pharmaceutical dosage form comprising a dosing unit comprising naloxone or a pharmaceutically acceptable salt thereof in an amount of equivalent to ?0.5 mg naloxone HCl dissolved in an application fluid of a volume of ?250 ?l. Furthermore, the present invention relates to such an intranasal pharmaceutical dosage form for use in the treatment of opioid overdosing and/or at least one symptom thereof.

Abstract: A device may receive security data identifying assets of an entity, security issues associated with the assets, and objectives associated with the assets and may utilize a data model to generate, based on the security data, asset related data identifying mapped sets of security data. The device may process a first portion of the asset related data, with a first model, to calculate an asset risk likelihood score for an asset of the assets and may process a second portion of the asset related data, with a second model, to calculate an asset criticality score for the asset. The device may process a third portion of the asset related data, with a third model, to calculate an asset control effectiveness score for the asset and may combine the scores to generate a security risk score for the asset. The device may provide the security risk score for display.

Abstract: A device may receive security data identifying assets of an entity, security issues associated with the assets, and objectives associated with the assets and may utilize a data model to generate, based on the security data, asset related data identifying mapped sets of security data. The device may process a first portion of the asset related data, with a first model, to calculate an asset risk likelihood score for an asset of the assets and may process a second portion of the asset related data, with a second model, to calculate an asset criticality score for the asset. The device may process a third portion of the asset related data, with a third model, to calculate an asset control effectiveness score for the asset and may combine the scores to generate a security risk score for the asset. The device may provide the security risk score for display.

Abstract: Flood Hinge is a novel system that allows an object to remain on its foundation in its normal resting position, to vertically and asymmetrically separate from this foundation upon application of an external force, while remaining securely tethered to the foundation, only to be guided to return to its original resting position as the external force subsides or is removed. This is accomplished by use of multiple parallel strut systems, each arranged in opposing positions.

Abstract: The present disclosure relates generally to computer architecture and infrastructure for guest operating systems executing on a host operating system. A method of authenticating and authorizing a user in an emulated computing environment is disclosed. The method includes receiving a request by a user operating on a guest operating system and having user credentials to invoke a process in a secure sandbox on a host operating system; searching a pool of credentials for the user credentials in the host operating system; associating the user credentials with the process such that all services running on a guest operating system have the same credentials as a host operating system; and after the process has completed, returning the user credentials to the pool.

Abstract: The present disclosure relates generally to computer architecture and infrastructure for guest operating systems executing on a host operating system. According to one embodiment, a method of allowing root file access includes receiving a request from a guest operating system to have root file access in a host operating system; determining, by the host operating system, if the request is asking for information relevant to the guest operating system itself, and if the request is asking for information that has the same credentials as the request; and if the information is relevant to the guest operating system itself and the information has the same credentials as the request, then providing a secure path to the relevant root file system on the host operating system.

Abstract: The present disclosure relates generally to computer architecture and infrastructure for guest operating systems executing on a host operating system. A method of allowing command sessions in a guest operating system includes receiving, by a host operating system, a request to invoke a command session by a guest operating system; receiving, by the host operating system, a request to invoke a bash interceptor; and loading bash code into a secure sandbox on the host operating system.

Abstract: The present disclosure relates generally to computer architecture and infrastructure for guest operating systems executing on a host operating system. A method of creating a guest-native executable includes receiving, by a host operating system, a call from a guest operating system to construct an executable from a guest-native source; creating an ecosystem for the guest-native source in a secure sandbox running on a host operating system; receiving the guest-native source; and executing the guest-native source in the ecosystem on the host operating system.

Abstract: The present disclosure elates generally to a computer architecture and infrastructure for guest operating systems executing on a host operating system. More particularly, it relates to methods and systems for allowing a guest operating system to control the resources of a commodity server system. A method of allowing a guest operating system to control and manage computer resources includes receiving, by a host operating system, a call from a guest operating system to control and manage computer resources; creating, by the host operating system, a secure sandbox executing on the host operating system; and creating, by the host operating system, a secure tunnel between the secure sandbox and the guest operating system, the secure tunnel having loopback networking. The secure sandbox is controlled and managed by the guest operating system but executing on the host operating system.

Abstract: The present disclosure relates generally to computer architecture and infrastructure for guest operating systems executing on a host operating system. A method of compiling and executing a new program in a secure sandbox. The method includes receiving, by a host operating system, a request from a guest operating system to invoke an execution environment in a secure sandbox on a host operating system; and execute the execution environment in the secure sandbox. The user can use the execution environment in the secure sand box from a guest operating system to compile and execute the new program on the host operating system.

Abstract: The present disclosure relates generally to computer architecture and infrastructure for guest operating systems executing on a host operating system. A method of invoking a native process as a called procedure, the method including receiving, by a host operating system, a request to invoke a native process as a called procedure form a guest operating system; loading the native process executable into a secure sandbox running on the host operating system; and transforming data from the native process into a representation appropriate for the called the procedure in the host operating environment.

Abstract: A tape wrap dispenser comprising an outer enclosure having a first side with a first aperture, a center section with a tape exit slot, and a second side with a second aperture. Also included are a first release/cut button which is attached to the first side, a second release/cut button which is attached to the second side, and a neck lanyard having a safety quick release routed through both the first aperture and the second aperture. There is a central hub inside the outer enclosure and a tape wrap roll mounted on the central hub and which extends through the tape exit slot. A mechanical linkage connected to the first and second release/cut buttons moves a cutter that cuts the tape at the tape exit slot. The outer enclosure should have a flat surface to prevent rolling.

Abstract: Disclosed herein is a diffuser module that can be used to air condition a space. The space may comprise the interior space(s) of buildings such as hospitals, enclosed shopping malls, warehouses, factories, etc. The module may comprise a body defining an interior chamber, the body having an upper end able to be connected to the air conditioning unit (AHU) and an opposing lower end. The module may also comprise a first channel disposed in the chamber for receiving a first air stream from the unit. The module may also comprise at least one diffuser connected to the lower end of the body, the at least one diffuser able to receive the first air stream from the first channel and discharge it to the space.

Abstract: The techniques described herein provide for a career management platform accessed by users (e.g., employees) through many mediums to help them manage and navigate their careers, skills, and/or experiences. The platform allows users to discover other potential opportunities that they may be interested in, provide relevant resources, and provide a means to gain experiences to help close various skills gaps and/or develop vital skills related to their current career, selected career destination, and/or defined career goals (purpose) statement. In one embodiment, opportunities are recommended to the user through the career management platform.

Abstract: Systems and methods for executing non-native instructions in a computing system having a processor configured to execute native instructions are provided. A dynamic translator uses instruction code translation in parallel with just-in-time (JIT) compilation to execute the non-native instructions. Non-native instructions may be interpreted to generate instruction codes, which may be stored in a shadow memory. During a subsequent scheduling of a non-native instruction for execution, the corresponding instruction code may be retrieved from the shadow memory and executed, thereby avoiding reinterpreting the non-native instruction. In addition, the JIT compiler may compile instruction codes to generate native instructions, which may be made available for execution, further speeding up the execution process.

Abstract: Systems and methods for executing non-native instructions in a computing system having a processor configured to execute native instructions are provided. A dynamic translator uses instruction code translation in parallel with just-in-time (JIT) compilation to execute the non-native instructions. Non-native instructions may be interpreted to generate instruction codes, which may be stored in a shadow memory. During a subsequent scheduling of a non-native instruction for execution, the corresponding instruction code may be retrieved from the shadow memory and executed, thereby avoiding reinterpreting the non-native instruction. In addition, the JIT compiler may compile instruction codes to generate native instructions, which may be made available for execution, further speeding up the execution process.

Abstract: An improved mechanically secured block building system generally for concrete masonry structures comprising a masonry block unit with a height and width essentially one-half the length of the unit, with multiple cavities through the block and with a recessed channel; an anchor bar with a plurality of threaded and non-threaded apertures in a special configuration to match the cavities in the block unit and able to lay in the recessed channel of the block; and a fastener wherein the mechanical secured block building system can be assembled in unique ways due to a cube effect of the masonry block to construct multiple width walls, grade beams, and horizontal decks. An alternative embodiment includes the preferred mechanical secured block building system further comprised of (d) a footer block and (e) a footer plate.