Abstract: The technology is directed to HIV envelopes which comprise sequence modifications wherein these modifications prevent CD4-induced transitions of the HIV Env. Provided also are compositions comprising envelopes of the technology, and methods of use.

Abstract: This disclosure relates to compounds of Formula (A): Formula (A), or a pharmaceutically acceptable salt thereof, wherein DSM is a degradation signaling moiety that is covalently attached to the linker L, L is a linker that covalently attaches IRAK to DSM; and IRAK is an IRAK4 binding moiety represented by Formula (I) that is covalently attached to linker L; Formula (I) in which all of the variables are as defined in the application. Compounds or pharmaceutically acceptable salts thereof as described herein are capable of activating the selective ubiqitination of IRAK4 proteins via the ubiquitin-proteasome pathways (UPP) and cause degradation of IRAK4 proteins. The present disclosure also provides methods of treating disorders responsive to modulation of IRAK4 activity and/or degradation of IRAK4 with at least one compound described herein.

Abstract: A portable grain storage bin including a circular sidewall having a top edge and a bottom edge, a conical cover coupled to and extending upwardly and radially inwardly from the top edge of the circular sidewall, to an opening and a partial floor extending radially inwardly from the bottom edge of the circular sidewall and terminating at a free edge. The circular sidewall, conical cover and partial floor are movable between a collapsed configuration when empty and a deployed configuration when filled.

Abstract: Electronic locks, electronic lock systems, and electronic lock networks are provided, and can include a latch, an interior unit including an interior handle operable to place the latch in the unlatched position, an interior user-interface, and an interior controller coupled to the interior user-interface; an exterior unit including an exterior handle having an active mode and a non-active mode, the exterior handle operable to place the latch in the unlatched position when in the active mode, an exterior user-interface, a fingerprint sensor configured to sense fingerprint data, and an exterior controller configure to receive the sensed fingerprint data, output the sensed fingerprint data, and place the exterior handle in the active mode upon receiving an active signal; and a main controller coupled to the interior controller and the exterior controller, the main controller configured to receive the sensed fingerprint data from the exterior controller, compare the sensed fingerprint data to a known fingerprint

Abstract: A fob includes a housing, a processor positioned within the housing, and a transceiver positioned within the housing and coupled to the processor. The transceiver is configured to send signals to a remote device. The fob also includes a touchpad supported by the housing and coupled to the processor. The touchpad is operable to discern a plurality of different gestures. Each gesture corresponds to a different signal being sent by the transceiver.

Abstract: Door locks, door locking and unlocking methods, and door security and communications devices are provided, and can include an exterior module mountable on an exterior surface of a door; an interior module mountable on an interior surface of a door; a deadbolt movable between an unlocked position allowing opening of the door from a closed state and a locked position preventing opening of the door from the closed state; a camera and/or a microphone provided on the exterior module; and a wireless communication device configured to communicate images from the camera and/or sound from the microphone to a smart phone or computer of an authorized user for remote observation of an area adjacent the exterior surface of the door.

Abstract: An electronic lock includes a lock mechanism, an actuator coupled to the lock mechanism and configured to lock and release the lock mechanism, and an actuator control circuit coupled to the actuator. The electronic lock also includes a battery electrically coupled to the actuator, a super capacitor electrically coupled to the battery, and a processor coupled to the actuator, the battery, and the super capacitor. The processor is configured to selectively receive power from the battery and the super capacitor, wherein the processor receives power from the super capacitor when a state of charge of the battery is below a predetermined voltage threshold, and provide control signals to the actuator control circuit to control operation of the actuator.

Abstract: Electronic locks, electronic lock systems, and electronic lock networks are provided, and can include a latch, an interior unit including an interior handle operable to place the latch in the unlatched position, an interior user-interface, and an interior controller coupled to the interior user-interface; an exterior unit including an exterior handle having an active mode and a non-active mode, the exterior handle operable to place the latch in the unlatched position when in the active mode, an exterior user-interface, a fingerprint sensor configured to sense fingerprint data, and an exterior controller configure to receive the sensed fingerprint data, output the sensed fingerprint data, and place the exterior handle in the active mode upon receiving an active signal; and a main controller coupled to the interior controller and the exterior controller, the main controller configured to receive the sensed fingerprint data from the exterior controller, compare the sensed fingerprint data to a known fingerprint

Abstract: An electronic lock includes a lock mechanism, an actuator coupled to the lock mechanism and configured to lock and release the lock mechanism, and an actuator control circuit coupled to the actuator. The electronic lock also includes a battery electrically coupled to the actuator, a super capacitor electrically coupled to the battery, and a processor coupled to the actuator, the battery, and the super capacitor. The processor is configured to selectively receive power from the battery and the super capacitor, wherein the processor receives power from the super capacitor when a state of charge of the battery is below a predetermined voltage threshold, and provide control signals to the actuator control circuit to control operation of the actuator.

Abstract: A security system includes a door having a door latch operable between a first position maintaining a closed state and a second position in which movement to an open state is enabled. A door handle on the door is graspable by a human hand to manipulate the door. A biometric scanner in the door handle is configured to detect a biometric parameter of an individual user. A biometric module receives an output of the biometric scanner to identify an authorized individual user. An actuator is operable in response to identification of the authorized individual user to move the door latch from the first position to the second position, or to release a lock which selectively retains the door latch in the first position so that the door is openable by manipulation of the door handle. Biometric scanners and modules for identifying users and triggering retrieval of vehicle settings of the users are also provided.

Abstract: Systems and methods for building an electronic device. One system includes a circuit board. A master controller and a plurality of modules are secured to the circuit board. Each of the plurality of modules is associated with manually-operable selection mechanism that allows the module to be placed in an active state or a deactivated state. The master controller can be configured to automatically identify a subset of the plurality of modules placed in the active state and to communicate with a software application executed on an external computing device to output identifying information for the subset of the plurality of modules to the software application. The master controller can also be configured to receive a configuration file from the software application, parse the configuration file, and transmit configuration data to each module included in the subset of the plurality of modules based at least in part on the parsed configuration file.

Abstract: A process is described for the production of propane-1,3-diol. The process comprises subjecting a vaporous feed mixture comprising a hydrogen-containing gas and a feedstock selected from 3-hydroxypropanal, ?-propiolactone, oligomers of ?-propiolactone, esters of 3-hydroxypropanoic acid, and mixtures of two or more thereof to hydrogenation conditions in a hydrogenation zone in the presence of a heterogeneous hydrogenation catalyst, and recovering a reaction product comprising propane-1,3-diol.

Abstract: This invention relates to a multilayer film comprising (a) a base layer having a first and second surface, wherein the base layer is comprised of at least one polyolefin, and (b) a skin layer on the first surface of the base layer, wherein the skin layer comprises at least about 70% by weight propylene homopolymer, and wherein the multilayer film has a deadfold value from about 45,000 to about 110,000 psi in the machine direction.

Abstract: A process is described for the production of propane-1,3-diol. The process comprises subjecting a vaporous feed mixture comprising a hydrogen-containing gas and a feedstock selected from 3-hydroxypropanal, &bgr;-propiolactone, oligomers of &bgr;-propiolactone, esters of 3-hydroxypropanoic acid, and mixtures of two or more thereof to hydrogenation conditions in a hydrogenation zone in the presence of a heterogeneous hydrogenation catalyst, and recovering a reaction product comprising propane-1,3-diol.

Abstract: A protective bumper and placemat in combination which is removably attachable to substantially any furniture edge. The apparatus is washable, portable and sanitary, and allows a child when seated at a table, to enjoy eating on a sanitary surface, or the child may use the apparatus as a play surface.

Abstract: An electrical connector comprises a housing of electrically insulative material and defining an interior compartment and passages extending from the interior compartment to an exterior surface of the housing. Electrical contact members are resident in the housing passages. At least one of the passages is circular in configuration and a power contact member resident in the one passage has a portion resident in the one passage circular in configuration and in press-fit sealed relation with the housing. The contact member resident in the one passage has a further portion resident in the interior compartment of blade-shaped configuration. A method of making the connector includes a step of press-fitting the power contact member into the one passage from the interior compartment with the contact member circular portion leading the contact member blade portion, such that the circular portion is in interference fit in the one passage and that the blade portion is resident in the interior compartment.

Abstract: A statement presenter for an automated teller machine includes a pair of upper belts (30) and a pair of lower belts (32). A paper stop (28) is mounted on a frame assembly (40). Cooperating arm members (42, 52) are operable to move the upper belts downwardly as the paper stop is moved upwardly and vice versa. In operation, the upper belts are moved upwardly while said paper stop is moved downwardly and a stack of papers (12) is accumulated. After accumulation of the stack, the paper stop is moved upwardly as the upper belt moves downwardly to engage the stack. Thereafter, the stack is moved outward to an exit slot (32) where the stack may be taken by a customer. If the customer fails to take the stack the direction of the belts is reversed until the stack engages a diverter plate (36) and passes into a storage bin (39) wherein the stack is held within the automated teller machine.