Abstract: Devices, systems, and techniques are disclosed for delivering electric field therapy to tissue of a subject. In one example, a technique includes removing a tumor from tissue to create a resection cavity, implanting a plurality of leads into the tissue adjacent to the resection cavity, and affixing the plurality of leads at least one of the tissue or bone. The example technique also includes tunneling proximal ends of the leads to an implantation pocket and coupling the proximal ends of the leads to an implantable medical device configured to be placed within the implantation pocket, wherein the implantable medical is configured to deliver electric field therapy via the plurality of implantable leads disposed adjacent to the resection cavity.

Abstract: A fluid regulator includes a poppet valve within a flow path that selectively allows a flow of fluid to move from an inlet to an outlet. A threaded regulating interface adjusts a spring tension exerted toward the poppet valve and defines a regulated flow of the fluid through the flow path. A fluid purge mechanism is positioned within the threaded regulating interface. The fluid purge mechanism operates along a rotational axis of the threaded regulating interface and adjusts a boundary of the flow path and manipulates the poppet valve to a maximum operating position to define a purging flow of the fluid. A programmable logic controller cooperates with the powered actuator and a pressure sensor to define a closed-loop interface that adjusts the regulated flow of the fluid through the flow path.

Abstract: A hybrid electric propulsion system includes a gas turbine engine having at least one compressor section and at least one turbine section operably coupled to a shaft. The hybrid electric propulsion system includes an electric motor configured to augment rotational power of the shaft of the gas turbine engine. A controller is operable to determine hybrid electric propulsion system parameters based on a composite system model and sensor data, determine a prediction based on the hybrid electric propulsion system parameters and the composite system model, determine a model predictive control optimization for a plurality of hybrid electric system control effectors based on the prediction using a plurality of reduced-order partitions of the composite system model, and actuate the hybrid electric system control effectors based on the model predictive control optimization.

Abstract: Various embodiments for system and method for cerebral implantation strategy for delivery of alternating electric field therapy are described. For example, a system may include processing circuitry configured for operative communication with a conformable grid comprising a plurality of modular grid elements having a plurality of electrodes configured for implantation in a cerebrum, and wherein the processing circuitry is configured to execute instructions stored in the memory to model brain tissue to define inter-contact and intra-contact distances along the conformable grid and each of the plurality of electrodes; determine the spacing between the plurality of modular grid elements of the conformable grid. A user interface may display a visual representation of the cerebrum including identification of a sub-region of the cerebrum and display a representation of the spacing between the plurality of modular grid elements of the conformable grid and a depth of each electrode of the plurality of electrodes.

Abstract: A hybrid electric propulsion system includes a gas turbine engine having at least one compressor section and at least one turbine section operably coupled to a shaft. The hybrid electric propulsion system includes an electric motor configured to augment rotational power of the shaft of the gas turbine engine. A controller is operable to determine an estimate of hybrid electric propulsion system parameters based on a composite system model and sensor data, determine a model predictive control state and a prediction based on the hybrid electric propulsion system parameters and the composite system model, determine a model predictive control optimization for a plurality of hybrid electric system control effectors based on the model predictive control state and the prediction using a plurality of reduced-order partitions of the composite system model, and actuate the hybrid electric system control effectors based on the model predictive control optimization.

Abstract: A hybrid electric propulsion system includes a gas turbine engine having at least one compressor section and at least one turbine section operably coupled to a shaft. The hybrid electric propulsion system includes an electric motor configured to augment rotational power of the shaft of the gas turbine engine. A controller is operable to determine an estimate of hybrid electric propulsion system parameters based on a composite system model and sensor data, determine a model predictive control state and a prediction based on the hybrid electric propulsion system parameters and the composite system model, determine a model predictive control optimization for a plurality of hybrid electric system control effectors based on the model predictive control state and the prediction using a plurality of reduced-order partitions of the composite system model, and actuate the hybrid electric system control effectors based on the model predictive control optimization.