Patents by Inventor Kevin Hinkle

Kevin Hinkle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PATATIN-LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 (PNPLA3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20240148773
    Abstract: The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the Patatin-Like Phospholipase Domain Containing 3 (PNPLA3) gene, and methods of using such RNAi agents to inhibit expression of a PNPLA3 gene and methods of treating subjects having Nonalcoholic Fatty Liver Disease (NAFLD) and/or a PNPLA3-associated disorder.
    Type: Application
    Filed: June 1, 2023
    Publication date: May 9, 2024
    Inventors: Kevin Fitzgerald, Gregory Hinkle
  • Chemical Compounds
    Publication number: 20120277258
    Abstract: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Application
    Filed: July 10, 2012
    Publication date: November 1, 2012
    Inventors: Amogh Boloor, Mui Cheung, Philip Anthony Harris, Kevin Hinkle, Christopher P. Laudeman, Jeffrey Alan Stafford, James Marvin Veal
  • Chemical compounds
    Patent number: 8114885
    Abstract: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Grant
    Filed: July 30, 2007
    Date of Patent: February 14, 2012
    Assignee: GlaxoSmithKline LLC
    Inventors: Amogh Boloor, Mui Cheung, Philip Anthony Harris, Kevin Hinkle, Jeffery Alan Stafford, James Marvin Veal
  • Pyrimidineamines as angiogenesis modulators
    Patent number: 7858626
    Abstract: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Grant
    Filed: July 30, 2007
    Date of Patent: December 28, 2010
    Assignee: GlaxoSmithKline LLC
    Inventors: Amogh Boloor, Mui Cheung, Ronda Gayle Davis-Ward, Philip Anthony Harris, Kevin Hinkle, Christopher P. Lauderman, Robert Anthony Mook, Jr., Jeffery Alan Stafford, James Marvin Veal
  • CHEMICAL COMPOUNDS
    Publication number: 20100105712
    Abstract: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Application
    Filed: October 30, 2009
    Publication date: April 29, 2010
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Amogh Boloor, Mui Cheung, Philip Anthony Harris, Kevin Hinkle, Jeffery Alan Stafford, James Marvin Veal
  • CHEMICAL COMPOUNDS
    Publication number: 20070292513
    Abstract: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Application
    Filed: July 30, 2007
    Publication date: December 20, 2007
    Inventors: Amogh Boloor, Mui Cheung, Ronda Davis, Philip Harris, Kevin Hinkle, Robert Mook, Jeffery Stafford, James Veal
  • Byrostatin analogues, synthetic methods and uses
    Publication number: 20070270485
    Abstract: Biologically active compounds related to the bryostatin family of compounds, having simplified spacer domains and/or improved recognition domains are disclosed, including methods of preparing and utilizing the same.
    Type: Application
    Filed: July 3, 2007
    Publication date: November 22, 2007
    Inventors: Paul Wender, Blaise Lippa, Cheol-Min Park, Kevin Hinkle
  • CHEMICAL COMPOUNDS
    Publication number: 20070270427
    Abstract: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Application
    Filed: July 30, 2007
    Publication date: November 22, 2007
    Inventors: Amogh Boloor, Mui Cheung, Ronda Davis, Philip Harris, Kevin Hinkle, Robert Mook, Jeffery Stafford, James Veal
  • Pyrimidineamines as angiogenesis modulators
    Patent number: 7262203
    Abstract: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: August 28, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Amogh Boloor, Mui Cheung, Ronda Davis, Philip Anthony Harris, Kevin Hinkle, Robert Anthony Mook, Jr., Jeffery Alan Stafford, James Marvin Veal
  • Chemical compounds
    Publication number: 20070015756
    Abstract: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Application
    Filed: May 15, 2006
    Publication date: January 18, 2007
    Inventors: Amogh Boloor, Mui Cheung, Ronda Davis, Philip Harris, Kevin Hinkle, Robert Mook, Jeffery Stafford, James Veal
  • Pyrimidineamines as angiogenesis modulators
    Patent number: 7105530
    Abstract: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also Includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: September 12, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Amogh Boloor, Mui Cheung, Ronda Davis, Philip Anthony Harris, Kevin Hinkle, Robert Anthony Mook, Jr., Jeffery Alan Stafford, James Marvin Veal
  • Pyrimidineamines as angiogenesis modulators
    Publication number: 20040242578
    Abstract: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Application
    Filed: June 9, 2004
    Publication date: December 2, 2004
    Inventors: Amogh Boloor, Mui Cheung, Ronda Davis, Philip Amthony Harris, Kevin Hinkle, Robert Anthony Mook, Jeffrey Alan Stafford, James Marvin Veal