Patents by Inventor Kevin Holden

Kevin Holden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240082046
    Abstract: An ostomy pouch, comprises: inner and outer walls of flexible sheet material defining a cavity for containing a stomal output; a deployable drain for draining stomal output from the cavity; and at least one sheet of comfort material. The drain moves between an extended configuration for draining the stomal output and a retracted configuration for storage of the drain. A first sheet of comfort material is attached to the outer wall, and a portion of the first sheet of comfort material forms a flap. The flap folds along a fold line, between a covering position and an access position; and the fold line is located between the deployable drain in the retracted position and an uppermost edge of the ostomy pouch.
    Type: Application
    Filed: November 22, 2023
    Publication date: March 14, 2024
    Inventors: Clare Holden, Alice Young, Kevin Evans
  • Publication number: 20210348173
    Abstract: The disclosure relates to recombinant host cells including strain modifications effective to improve titer, yield and/or productivity of fatty acid derivatives. The disclosure further relates to cell cultures including the recombinant host cells for the fermentative production of fatty acid derivatives and compositions thereof.
    Type: Application
    Filed: June 1, 2021
    Publication date: November 11, 2021
    Inventors: Derek L. GREENFIELD, Andreas W. SCHIRMER, Elizabeth J. CLARKE, Eli S. GROBAN, Bernardo M. DA COSTA, Zhihao HU, Kevin HOLDEN, Noah HELMAN
  • Publication number: 20210324431
    Abstract: Recombinant microbial cells are provided which have been engineered to produce fatty acid derivatives having linear chains containing an odd number of carbon atoms by the fatty acid biosynthetic pathway. Also provided are methods of making odd chain fatty acid derivatives using the recombinant microbial cells, and compositions comprising odd chain fatty acid derivatives produced by such methods.
    Type: Application
    Filed: February 8, 2021
    Publication date: October 21, 2021
    Inventors: Grace J. LEE, John HALIBURTON, Zhihao HU, Andreas W. SCHIRMER, Kevin HOLDEN
  • Publication number: 20210309979
    Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.
    Type: Application
    Filed: December 9, 2020
    Publication date: October 7, 2021
    Inventors: Andrew M. SHUMAKER, Bernardo M. DA COSTA, Kevin HOLDEN, Louis G. HOM, Tarah S. BARON, Noah HELMAN
  • Patent number: 11060099
    Abstract: The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: July 13, 2021
    Assignee: Genomatica, Inc.
    Inventors: Derek L. Greenfield, Andreas W. Schirmer, Elizabeth J. Clarke, Eli S. Groban, Bernardo M. Da Costa, Zhihao Hu, Kevin Holden, Noah Helman
  • Patent number: 10894953
    Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: January 19, 2021
    Assignee: Genomatica, Inc.
    Inventors: Andrew M. Shumaker, Bernardo M. da Costa, Kevin Holden, Louis G. Hom, Tarah S. Baron, Noah Helman
  • Publication number: 20180327728
    Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.
    Type: Application
    Filed: January 18, 2018
    Publication date: November 15, 2018
    Inventors: Andrew M. SHUMAKER, Bernardo M. da Costa, Kevin HOLDEN, Louis G. HOM, Tarah S. BARON, Noah HELMAN
  • Patent number: 9879239
    Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 30, 2018
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Andrew M. Shumaker, Bernardo M. Da Costa, Kevin Holden, Louis G. Hom, Tarah S. Baron, Noah Helman
  • Publication number: 20180010137
    Abstract: The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell.
    Type: Application
    Filed: July 14, 2017
    Publication date: January 11, 2018
    Inventors: Derek L. GREENFIELD, Andreas W. Schirmer, Elizabeth J. CLARKE, Eli S. GROBAN, Bernardo M. Da Costa, Zhihao Hu, Kevin Holden, Noah Helman
  • Publication number: 20160002681
    Abstract: The disclosure relates to recombinant microorganisms that exhibit an increased expression of an acyl carrier protein (ACP) resulting in production of fatty acid derivatives. The disclosure further relates to methods of using the recombinant microorganisms in fermentation cultures in order to produce fatty acid derivatives and related compositions.
    Type: Application
    Filed: December 11, 2013
    Publication date: January 7, 2016
    Applicant: REG LIFE SCIENCES, LLC
    Inventors: David SIMPSON, Bernardo DA COSTA, Mathew RUDE, Na TRINH, Emanuela POPOVA, Sankaranarayanan VENKITESWARAN, Noah HELMAN, Kevin HOLDEN
  • Publication number: 20150299679
    Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.
    Type: Application
    Filed: March 15, 2013
    Publication date: October 22, 2015
    Applicant: REG Life Sciences, LLC.
    Inventors: Andrew M. SHUMAKER, Bernardo M. DA COSTA, Kevin HOLDEN, Louis G. HOM, Tarah S. BARON, Noah HELMAN
  • Patent number: 8530221
    Abstract: Recombinant microbial cells are provided which have been engineered to produce branched chain products such as branched fatty acid derivatives by the fatty acid biosynthetic pathway, and methods of making branched fatty acid derivatives using the recombinant microbial cells.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: September 10, 2013
    Assignee: LS9, Inc.
    Inventors: Zhihao Hu, Grace J. Lee, Andreas W. Schirmer, Kseniya Zakharyevich, Derek L. Greenfield, Tarah S. Baron, Kevin Holden
  • Publication number: 20110244532
    Abstract: Recombinant microbial cells are provided which have been engineered to produce branched chain products such as branched fatty acid derivatives by the fatty acid biosynthetic pathway, and methods of making branched fatty acid derivatives using the recombinant microbial cells.
    Type: Application
    Filed: May 10, 2011
    Publication date: October 6, 2011
    Applicant: LS9, INC.
    Inventors: Zhihao Hu, Grace J. Lee, Andreas W. Schirmer, Kseniya Zakharyevich, Derek L. Greenfield, Tarah S. Baron, Kevin Holden