Patents by Inventor Kevin Holmes

Kevin Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230340057
    Abstract: The invention relates to parathyroid hormone (PTH) variants and pharmaceutical compositions comprising same. The invention further relates to PTH compositions with improved serum half-life and peak-trough ratios, and methods of controlling serum calcium levels with the PTH variants and compositions of the invention. The invention further relates to methods of treating hypoparathyroidism and/or hypocalcemia due to hypoparathyroidism with the PTH variants and compositions of the invention.
    Type: Application
    Filed: March 2, 2023
    Publication date: October 26, 2023
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Clark PAN, Angela NORTON, Kevin HOLMES, David LLOYD, Bryan GOODWIN, Rongxin SHI, Sujit JAIN, Chuan SHEN
  • Patent number: 11767743
    Abstract: A downhole fluid injection system comprising: a first fluid line including a first end, a second end, and an intermediate portion, the first end being connected to a fluid source, the first fluid line being extendable along a first portion of a wellbore; and a second fluid line including a first end section, a second end section, and an intermediate section, the second fluid line being extendable along a second portion of the wellbore that extends at an angle relative to the first portion and includes a plurality of fluid injectors arranged along the intermediate section.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: September 26, 2023
    Assignee: BAKER HUGHES, A GE COMPANY, LLC
    Inventors: David Lerohl, Pavel Nazarenko, Kevin Holmes, John Raggio
  • Patent number: 11634468
    Abstract: The invention relates to parathyroid hormone (PTH) variants and pharmaceutical compositions comprising same. The invention further relates to PTH compositions with improved serum half-life and peak-trough ratios, and methods of controlling serum calcium levels with the PTH variants and compositions of the invention. The invention further relates to methods of treating hypoparathyroidism and/or hypocalcemia due to hypoparathyroidism with the PTH variants and compositions of the invention.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: April 25, 2023
    Assignee: SHIRE-NPS PHARMACEUTICALS, INC.
    Inventors: Clark Pan, Angela Norton, Kevin Holmes, David Bruce Lloyd, Bryan James Goodwin, Rongxin Shi, Sujit Jain, Chuan Shen
  • Patent number: 11512554
    Abstract: A segmented backup ring including a plurality of individual segments each having curved surfaces that define an arcuate portion of the ring, each segment including a body section having the arcuate profile and defining a receptacle therein having a circumferential dimension, a projection section having a head portion and a neck portion and extending from the body section in a circumferential direction of the ring, the projection section being receivable and retainable in the receptacle of an adjacent segment body section, and the head portion having a dimension in line with the circumferential direction of the ring that is shorter than the circumferential dimension of the receptacle.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: November 29, 2022
    Assignee: BAKER HUGHES HOLDINGS LLC
    Inventors: Guijun Deng, Kevin Holmes, Daniel Ewing, Keith J. Murphy
  • Publication number: 20220133863
    Abstract: Among other things, the present invention provides methods and compositions of treating Sanfilippo syndrome type B (Sanfilippo B) by, e.g., intrathecal (IT) administration of a Naglu protein. A suitable Naglu protein can be a recombinant, gene-activated or natural protein. In some embodiments, a suitable Naglu protein is a recombinant Naglu protein. In some embodiments, a recombinant Naglu protein is a fusion protein containing a Naglu domain and a lysosomal targeting moiety. In some embodiments, the lysosomal targeting domain is an IGF-II moiety.
    Type: Application
    Filed: June 17, 2021
    Publication date: May 5, 2022
    Inventors: Michael F. Concino, Pericles Calias, Jing Pan, Kevin Holmes, Paolo Martini, Alla Romashko, Muthuraman Meiyappan, Bohong Zhang, Andrea Iskenderian, Dianna Lundberg, Angela Norton, Bettina Strack-Logue, Huang Yan, Mary Alessandrini, Richard Pfeifer
  • Publication number: 20220081991
    Abstract: A segmented backup ring including a plurality of individual segments each having curved surfaces that define an arcuate portion of the ring, each segment including a body section having the arcuate profile and defining a receptacle therein having a circumferential dimension, a projection section having a head portion and a neck portion and extending from the body section in a circumferential direction of the ring, the projection section being receivable and retainable in the receptacle of an adjacent segment body section, and the head portion having a dimension in line with the circumferential direction of the ring that is shorter than the circumferential dimension of the receptacle.
    Type: Application
    Filed: September 15, 2020
    Publication date: March 17, 2022
    Applicant: Baker Hughes Holdings LLC
    Inventors: Guijun Deng, Kevin Holmes, Daniel Ewing, Keith J. Murphy
  • Patent number: 11065307
    Abstract: Among other things, the present invention provides methods and compositions of treating Sanfilippo syndrome type B (Sanfilippo B) by, e.g., intrathecal (IT) administration of a Naglu protein. A suitable Naglu protein can be a recombinant, gene-activated or natural protein. In some embodiments, a suitable Naglu protein is a recombinant Naglu protein. In some embodiments, a recombinant Naglu protein is a fusion protein containing a Naglu domain and a lysosomal targeting moiety. In some embodiments, the lysosomal targeting domain is an IGF-II moiety.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: July 20, 2021
    Assignee: Shire Human Genetic Therapies, Inc.
    Inventors: Michael F. Concino, Pericles Calias, Jing Pan, Kevin Holmes, Paolo Martini, Alla Romashko, Muthuraman Meiyappan, Bohong Zhang, Andrea Iskenderian, Dianna Lundberg, Angela Norton, Bettina Strack-Logue, Huang Yan, Mary Alessandrini, Richard Pfeifer
  • Patent number: 10830012
    Abstract: A tubular system includes a side pocket mandrel having at least one side pocket defining a device storage zone. A conductor extends along the tubular system to the side pocket. A stored device is arranged in the device storage zone.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: November 10, 2020
    Assignee: BAKER HUGES, A GE COMPANY, LLC
    Inventors: Kevin Holmes, Pavel Nazarenko, Jason M. Harper
  • Publication number: 20200247865
    Abstract: The invention relates to parathyroid hormone (PTH) variants and pharmaceutical compositions comprising same. The invention further relates to PTH compositions with improved serum half-life and peak-trough ratios, and methods of controlling serum calcium levels with the PTH variants and compositions of the invention. The invention further relates to methods of treating hypoparathyroidism and/or hypocalcemia due to hypoparathyroidism with the PTH variants and compositions of the invention.
    Type: Application
    Filed: January 29, 2020
    Publication date: August 6, 2020
    Applicant: Shire-NPS Pharmaceuticals, Inc.
    Inventors: Clark PAN, Angela NORTON, Kevin HOLMES, David Bruce LLOYD, Bryan James GOODWIN, Rongxin SHI, Sujit JAIN, Chuan SHEN
  • Patent number: 10603364
    Abstract: The invention provides compositions and methods for effective lysosomal targeting mediated by SORT1. In particular, the compositions and methods provided by the invention may be used to treat lysosomal storage diseases such as Sanfilippo syndrome type B.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: March 31, 2020
    Assignee: Shire Human Genetic Therapies, Inc.
    Inventors: Michael F. Concino, Bettina Strack-Logue, Muthuraman Meiyappan, Angela W. Norton, Bohong Zhang, Andrea Iskenderian, Jianwen Feng, Kevin Holmes, Jing Pan
  • Publication number: 20200032632
    Abstract: A downhole fluid injection system comprising: a first fluid line including a first end, a second end, and an intermediate portion, the first end being connected to a fluid source, the first fluid line being extendable along a first portion of a wellbore; and a second fluid line including a first end section, a second end section, and an intermediate section, the second fluid line being extendable along a second portion of the wellbore that extends at an angle relative to the first portion and includes a plurality of fluid injectors arranged along the intermediate section.
    Type: Application
    Filed: July 26, 2019
    Publication date: January 30, 2020
    Applicant: Baker Hughes, a GE company, LLC
    Inventors: David Lerohl, Pavel Nazarenko, Kevin Holmes, John Raggio
  • Patent number: 10449441
    Abstract: In a method of notifying a user of an option to participate in a meta game, a presence of a player of a computer-implemented game at a location is detected. An association between a computer-implemented meta-game and the location is identified. The player of the computer-implemented game is presented with an option to participate in the computer-implemented meta-game. An indication of an acceptance of the option to participate in the computer-implemented meta game is received from the player of the computer-implemented game. A performance of an action within the computer-implemented game by the player of the computer-implemented game is reflected within the computer-implemented meta game.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: October 22, 2019
    Assignee: Zynga Inc.
    Inventors: Justin Rouse, Kevin Holme, Daniel Hurd, Jason Tomlinson, Grant Yang, Shawn Lohstroh, Jessica Oyhenart, David Chow
  • Publication number: 20190128109
    Abstract: A tubular system includes a side pocket mandrel having at least one side pocket defining a device storage zone. A conductor extends along the tubular system to the side pocket. A stored device is arranged in the device storage zone.
    Type: Application
    Filed: August 21, 2018
    Publication date: May 2, 2019
    Applicant: Baker Hughes, a GE company, LLC
    Inventors: Kevin Holmes, Pavel Nazarenko, Jason M. Harper
  • Publication number: 20180333473
    Abstract: The present invention provides, among other things, a conjugated C1-INH for improved treatment of complement-mediated disorders, including hereditary angioedema (HAE). In some embodiments, a conjugated C1-INH provided by the present invention is a PEGylated C1-INH. In some embodiments, a conjugated C1-INH provided by the present invention is a polysialic acid (PSA) conjugated C1-INH.
    Type: Application
    Filed: April 17, 2018
    Publication date: November 22, 2018
    Inventors: Kevin Holmes, Angela Norton, Clark Pan
  • Patent number: 10060253
    Abstract: A method of determining a condition within a wellbore. The method comprises introducing a tubular member in a wellbore extending through a subterranean formation, the tubular member comprising a downhole article including a deformable material disposed around a surface of the tubular member, electrically conductive elements dispersed within the deformable material. The method includes measuring at least one electrical property of the deformable material. At least one of water ingress into the wellbore or an amount of expansion of the deformable material is determined based on the at least one measured electrical property. Related downhole systems and other related methods are also disclosed.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: August 28, 2018
    Assignee: Baker Hughes Incorporated
    Inventors: Darryl N. Ventura, Rostyslav Dolog, Valery N. Khabashesku, Nicholas Carrejo, Kevin Holmes, Thomas McClain Scott, Xiuli Wang
  • Publication number: 20180085438
    Abstract: Among other things, the present invention provides methods and compositions of treating Sanfilippo syndrome type B (Sanfilippo B) by, e.g., intrathecal (IT) administration of a Naglu protein. A suitable Naglu protein can be a recombinant, gene-activated or natural protein. In some embodiments, a suitable Naglu protein is a recombinant Naglu protein. In some embodiments, a recombinant Naglu protein is a fusion protein containing a Naglu domain and a lysosomal targeting moiety. In some embodiments, the lysosomal targeting domain is an IGF-II moiety.
    Type: Application
    Filed: September 26, 2017
    Publication date: March 29, 2018
    Inventors: Michael F. Concino, Pericles Calias, Jing Pan, Kevin Holmes, Paolo Martini, Alla Romashko, Muthuraman Meiyappan, Bohong Zhang, Andrea Iskenderian, Dianna Lundberg, Angela Norton, Bettina Strack-Logue, Huang Yan, Mary Alessandrini, Richard Pfeifer
  • Publication number: 20180036633
    Abstract: In a method of notifying a user of an option to participate in a meta game, a presence of a player of a computer-implemented game at a location is detected. An association between a computer-implemented meta-game and the location is identified. The player of the computer-implemented game is presented with an option to participate in the computer-implemented meta-game. An indication of an acceptance of the option to participate in the computer-implemented meta game is received from the player of the computer-implemented game. A performance of an action within the computer-implemented game by the player of the computer-implemented game is reflected within the computer-implemented meta game.
    Type: Application
    Filed: October 17, 2017
    Publication date: February 8, 2018
    Inventors: Justin Rouse, Kevin Holme, Daniel Hurd, Jason Tomlinson, Grant Yang, Shawn Lohstroh, Jessica Oyhenart, David Chow
  • Publication number: 20170360905
    Abstract: The present invention provides, among other things, a conjugated C1-INH for improved treatment of complement-mediated disorders, including hereditary angioedema (HAE). In some embodiments, a conjugated C1-INH provided by the present invention is a PEGylated C1-INH. In some embodiments, a conjugated C1-INH provided by the present invention is a polysialic acid (PSA) conjugated C1-INH.
    Type: Application
    Filed: April 4, 2017
    Publication date: December 21, 2017
    Inventors: Kevin Holmes, Angela Norton, Clark Pan
  • Patent number: 9833699
    Abstract: In a method of notifying a user of an option to participate in a meta game, a presence of a player of a computer-implemented game at a location is detected. An association between a computer-implemented meta-game and the location is identified. The player of the computer-implemented game is presented with an option to participate in the computer-implemented meta-game. An indication of an acceptance of the option to participate in the computer-implemented meta game is received from the player of the computer-implemented game. A performance of an action within the computer-implemented game by the player of the computer-implemented game is reflected within the computer-implemented meta game.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: December 5, 2017
    Assignee: Zynga Inc.
    Inventors: Justin Rouse, Kevin Holme, Daniel Hurd, Jason Tomlinson, Grant Yang, Shawn Lohstroh, Jessica Oyhenart, David Chow
  • Patent number: 9814764
    Abstract: Among other things, the present invention provides methods and compositions of treating Sanfilippo syndrome type B (Sanfilippo B) by, e.g., intrathecal (IT) administration of a Naglu protein. A suitable Naglu protein can be a recombinant, gene-activated or natural protein. In some embodiments, a suitable Naglu protein is a recombinant Naglu protein. In some embodiments, a recombinant Naglu protein is a fusion protein containing a Naglu domain and a lysosomal targeting moiety. In some embodiments, the lysosomal targeting domain is an IGF-II moiety.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: November 14, 2017
    Assignee: Shire Human Genetic Therapies, Inc.
    Inventors: Michael F. Concino, Pericles Calias, Jing Pan, Kevin Holmes, Paolo Martini, Alla Romashko, Muthuraman Meiyappan, Bohong Zhang, Andrea Iskenderian, Dianna Lundberg, Angela Norton, Bettina Strack-Logue, Huang Yan, Mary Alessandrini, Richard Pfeifer