Abstract: Disclosed herein is a sprung dispensing tower that includes a vertical housing having an open top and an interior dimensioned to receive products in a vertical stacked relationship. The sprung dispensing tower includes a platform within the interior of the vertical housing, the platform having a horizontal component and platform sidewalls depending from the horizontal component in parallel with respective interior sidewalls of the vertical housing, the platform being vertically slideable within the interior of the vertical housing between an uppermost position and a lowermost position. The sprung dispensing tower includes a compressible spring associated with an underside of the platform and biasing the platform towards the uppermost position. The sprung dispensing tower includes a resiliently compressible slide guide affixed to at least a portion of the platform sidewalls and extending laterally towards the interior sidewalls of the vertical housing.

Abstract: The invention relates to parathyroid hormone (PTH) variants and pharmaceutical compositions comprising same. The invention further relates to PTH compositions with improved serum half-life and peak-trough ratios, and methods of controlling serum calcium levels with the PTH variants and compositions of the invention. The invention further relates to methods of treating hypoparathyroidism and/or hypocalcemia due to hypoparathyroidism with the PTH variants and compositions of the invention.

Abstract: A downhole fluid injection system comprising: a first fluid line including a first end, a second end, and an intermediate portion, the first end being connected to a fluid source, the first fluid line being extendable along a first portion of a wellbore; and a second fluid line including a first end section, a second end section, and an intermediate section, the second fluid line being extendable along a second portion of the wellbore that extends at an angle relative to the first portion and includes a plurality of fluid injectors arranged along the intermediate section.

Abstract: The invention relates to parathyroid hormone (PTH) variants and pharmaceutical compositions comprising same. The invention further relates to PTH compositions with improved serum half-life and peak-trough ratios, and methods of controlling serum calcium levels with the PTH variants and compositions of the invention. The invention further relates to methods of treating hypoparathyroidism and/or hypocalcemia due to hypoparathyroidism with the PTH variants and compositions of the invention.

Abstract: A segmented backup ring including a plurality of individual segments each having curved surfaces that define an arcuate portion of the ring, each segment including a body section having the arcuate profile and defining a receptacle therein having a circumferential dimension, a projection section having a head portion and a neck portion and extending from the body section in a circumferential direction of the ring, the projection section being receivable and retainable in the receptacle of an adjacent segment body section, and the head portion having a dimension in line with the circumferential direction of the ring that is shorter than the circumferential dimension of the receptacle.

Abstract: Among other things, the present invention provides methods and compositions of treating Sanfilippo syndrome type B (Sanfilippo B) by, e.g., intrathecal (IT) administration of a Naglu protein. A suitable Naglu protein can be a recombinant, gene-activated or natural protein. In some embodiments, a suitable Naglu protein is a recombinant Naglu protein. In some embodiments, a recombinant Naglu protein is a fusion protein containing a Naglu domain and a lysosomal targeting moiety. In some embodiments, the lysosomal targeting domain is an IGF-II moiety.

Abstract: A segmented backup ring including a plurality of individual segments each having curved surfaces that define an arcuate portion of the ring, each segment including a body section having the arcuate profile and defining a receptacle therein having a circumferential dimension, a projection section having a head portion and a neck portion and extending from the body section in a circumferential direction of the ring, the projection section being receivable and retainable in the receptacle of an adjacent segment body section, and the head portion having a dimension in line with the circumferential direction of the ring that is shorter than the circumferential dimension of the receptacle.

Abstract: Among other things, the present invention provides methods and compositions of treating Sanfilippo syndrome type B (Sanfilippo B) by, e.g., intrathecal (IT) administration of a Naglu protein. A suitable Naglu protein can be a recombinant, gene-activated or natural protein. In some embodiments, a suitable Naglu protein is a recombinant Naglu protein. In some embodiments, a recombinant Naglu protein is a fusion protein containing a Naglu domain and a lysosomal targeting moiety. In some embodiments, the lysosomal targeting domain is an IGF-II moiety.

Abstract: A tubular system includes a side pocket mandrel having at least one side pocket defining a device storage zone. A conductor extends along the tubular system to the side pocket. A stored device is arranged in the device storage zone.

Abstract: The invention relates to parathyroid hormone (PTH) variants and pharmaceutical compositions comprising same. The invention further relates to PTH compositions with improved serum half-life and peak-trough ratios, and methods of controlling serum calcium levels with the PTH variants and compositions of the invention. The invention further relates to methods of treating hypoparathyroidism and/or hypocalcemia due to hypoparathyroidism with the PTH variants and compositions of the invention.

Abstract: The invention provides compositions and methods for effective lysosomal targeting mediated by SORT1. In particular, the compositions and methods provided by the invention may be used to treat lysosomal storage diseases such as Sanfilippo syndrome type B.

Abstract: A downhole fluid injection system comprising: a first fluid line including a first end, a second end, and an intermediate portion, the first end being connected to a fluid source, the first fluid line being extendable along a first portion of a wellbore; and a second fluid line including a first end section, a second end section, and an intermediate section, the second fluid line being extendable along a second portion of the wellbore that extends at an angle relative to the first portion and includes a plurality of fluid injectors arranged along the intermediate section.

Abstract: In a method of notifying a user of an option to participate in a meta game, a presence of a player of a computer-implemented game at a location is detected. An association between a computer-implemented meta-game and the location is identified. The player of the computer-implemented game is presented with an option to participate in the computer-implemented meta-game. An indication of an acceptance of the option to participate in the computer-implemented meta game is received from the player of the computer-implemented game. A performance of an action within the computer-implemented game by the player of the computer-implemented game is reflected within the computer-implemented meta game.

Abstract: A tubular system includes a side pocket mandrel having at least one side pocket defining a device storage zone. A conductor extends along the tubular system to the side pocket. A stored device is arranged in the device storage zone.

Abstract: The present invention provides, among other things, a conjugated C1-INH for improved treatment of complement-mediated disorders, including hereditary angioedema (HAE). In some embodiments, a conjugated C1-INH provided by the present invention is a PEGylated C1-INH. In some embodiments, a conjugated C1-INH provided by the present invention is a polysialic acid (PSA) conjugated C1-INH.

Abstract: A method of determining a condition within a wellbore. The method comprises introducing a tubular member in a wellbore extending through a subterranean formation, the tubular member comprising a downhole article including a deformable material disposed around a surface of the tubular member, electrically conductive elements dispersed within the deformable material. The method includes measuring at least one electrical property of the deformable material. At least one of water ingress into the wellbore or an amount of expansion of the deformable material is determined based on the at least one measured electrical property. Related downhole systems and other related methods are also disclosed.

Abstract: Among other things, the present invention provides methods and compositions of treating Sanfilippo syndrome type B (Sanfilippo B) by, e.g., intrathecal (IT) administration of a Naglu protein. A suitable Naglu protein can be a recombinant, gene-activated or natural protein. In some embodiments, a suitable Naglu protein is a recombinant Naglu protein. In some embodiments, a recombinant Naglu protein is a fusion protein containing a Naglu domain and a lysosomal targeting moiety. In some embodiments, the lysosomal targeting domain is an IGF-II moiety.

Abstract: In a method of notifying a user of an option to participate in a meta game, a presence of a player of a computer-implemented game at a location is detected. An association between a computer-implemented meta-game and the location is identified. The player of the computer-implemented game is presented with an option to participate in the computer-implemented meta-game. An indication of an acceptance of the option to participate in the computer-implemented meta game is received from the player of the computer-implemented game. A performance of an action within the computer-implemented game by the player of the computer-implemented game is reflected within the computer-implemented meta game.

Abstract: The present invention provides, among other things, a conjugated C1-INH for improved treatment of complement-mediated disorders, including hereditary angioedema (HAE). In some embodiments, a conjugated C1-INH provided by the present invention is a PEGylated C1-INH. In some embodiments, a conjugated C1-INH provided by the present invention is a polysialic acid (PSA) conjugated C1-INH.

Abstract: In a method of notifying a user of an option to participate in a meta game, a presence of a player of a computer-implemented game at a location is detected. An association between a computer-implemented meta-game and the location is identified. The player of the computer-implemented game is presented with an option to participate in the computer-implemented meta-game. An indication of an acceptance of the option to participate in the computer-implemented meta game is received from the player of the computer-implemented game. A performance of an action within the computer-implemented game by the player of the computer-implemented game is reflected within the computer-implemented meta game.