Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.

Abstract: A drill bit has a plurality of cutters secured to the bit body, including a gauge cutter defining a gauge diameter of the drill bit. A reciprocating gauge assembly on the bit comprises a cavity defined in the bit body, a piston reciprocably disposed in the cavity, a wear element on an outwardly facing end of the piston, a piston retainer for moveably retaining the piston in the cavity, and a spring biasing the piston outwardly to a neutral position of the wear element with respect to the gauge diameter. The wear element and piston may be urged inwardly in response to an applied load at the drill bit gauge pad, increasing the lateral depth of cut and thereby controlling the aggressiveness of the bit in response to the load.

Abstract: In some examples, an endovascular medical device includes an elongated body configured to be introduced in a cranial blood vessel of a patient and an expandable element on the elongated body. The expandable element includes a plurality of loops, wherein each loop includes one or more electrodes. The expandable element is configured to expand radially outwards from a relatively low-profile delivery configuration to a deployed configuration to position the one or more electrodes to deliver electrical stimulation to tissue of a brain of a patient or sense a patient parameter from a location within the cranial blood vessel.

Abstract: Provided herein are solutions and dried forms of extracellular vesicles (EVs) that are useful as therapeutic agents, and therapeutic compositions thereof.

Abstract: Provided herein are methods and pharmaceutical compositions related to the bacteria and microbial extracellular vesicles (mEVs) of Fournierella massiliensis that are useful as therapeutic agents.

Abstract: Provided herein are methods and pharmaceutical compositions related to the bacteria and microbial extracellular vesicles (mEVs) of Harryflintia acetispora that are useful as therapeutic agents.

Abstract: The present disclosure is related to the field of diabetes diagnostics. It introduces novel biomarkers that can be used to predict diabetes and detect presence of the disease. In addition, novel fatty acid biomarkers are presented.

Abstract: An apparatus for hydrating the lower body portions and/or hands of a user. The apparatus includes a chamber for receiving and containing steam and the lower body portions and/or hands of the user. The chamber includes a bottom surface and a wall structure extending upwardly from the bottom surface. Steam from the steam generator is transported via a hose in communication with the steam generator and the chamber. Inside the chamber, the hose is in communication with a steam distribution apparatus. Steam passing through the steam distribution apparatus fills the chamber.