Patents by Inventor Kevin J. Arvai

Kevin J. Arvai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and compositions for detecting an adenoma-adenocarcinoma transition in cancer
    Patent number: 12000831
    Abstract: Methods and kits for detecting alternating spatial expression of PTEN and, optionally, SMAD4, CD44, and/or TP53 in colonic tumors are described. The methods and kits are useful for identifying a cancer stem cell (CSC)-like zone within a colonic tumor, identifying an adenoma-adenocarcinoma (Ad-ACA) transition zone in a colorectal cancer (CRC) tumor, identifying a CRC tumor that contains high-grade adenoma and/or early adenocarcinoma regions, identifying CSCs in a CRC tumor, diagnosing a subject with high-grade colon adenoma and/or early adenocarcinoma, and determining the likelihood that a colonic tumor in a subject will undergo invasive transformation if left untreated.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: June 4, 2024
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Daniel Jones, Kevin J. Arvai, Ya-Hsuan Hsu
  • COMPOSITIONS AND METHODS FOR DETERMINING ENDOMETRIAL CANCER PROGNOSIS
    Publication number: 20230193358
    Abstract: The present invention provides methods and compositions for determining prognosis in individual with cancer, in particular endometrial cancer. The present invention also provides methods of developing and using predictive models that are useful for determining prognosis of endometrial cancer and other similar diseases. The present invention further provides methods for determining microsatellite status using next generation sequencing.
    Type: Application
    Filed: February 21, 2023
    Publication date: June 22, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Yongbao WANG, Kevin J. ARVAI, Daniel JONES
  • METHOD AND COMPOSITIONS FOR DETECTING AN ADENOMA-ADENOCARCINOMA TRANSITION IN CANCER
    Publication number: 20210255188
    Abstract: Methods and kits for detecting alternating spatial expression of PTEN and, optionally, SMAD4, CD44, and/or TP53 in colonic tumors are described. The methods and kits are useful for identifying a cancer stem cell (CSC)-like zone within a colonic tumor, identifying an adenoma-adenocarcinoma (Ad-ACA) transition zone in a colorectal cancer (CRC) tumor, identifying a CRC tumor that contains high-grade adenoma and/or early adenocarcinoma regions, identifying CSCs in a CRC tumor, diagnosing a subject with high-grade colon adenoma and/or early adenocarcinoma, and determining the likelihood that a colonic tumor in a subject will undergo invasive transformation if left untreated.
    Type: Application
    Filed: January 11, 2021
    Publication date: August 19, 2021
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Daniel Jones, Kevin J. Arvai, Ya-Hsuan Hsu
  • Method and compositions for detecting an adenoma-adenocarcinoma transition in cancer
    Patent number: 10890587
    Abstract: Methods and kits for detecting alternating spatial expression of PTEN and, optionally, SMAD4, CD44, and/or TP53 in colonic tumors are described. The methods and kits are useful for identifying a cancer stem cell (CSC)-like zone within a colonic tumor, identifying an adenoma-adenocarcinoma (Ad-ACA) transition zone in a colorectal cancer (CRC) tumor, identifying a CRC tumor that contains high-grade adenoma and/or early adenocarcinoma regions, identifying CSCs in a CRC tumor, diagnosing a subject with high-grade colon adenoma and/or early adenocarcinoma, and determining the likelihood that a colonic tumor in a subject will undergo invasive transformation if left untreated.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: January 12, 2021
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Daniel Jones, Kevin J. Arvai, Ya-Hsuan Hsu
  • COMPOSITIONS AND METHODS FOR DETERMINING ENDOMETRIAL CANCER PROGNOSIS
    Publication number: 20180094301
    Abstract: The present invention provides methods and compositions for determining prognosis in individual with cancer, in particular endometrial cancer. The present invention also provides methods of developing and using predictive models that are useful for determining prognosis of endometrial cancer and other similar diseases. The present invention further provides methods for determining microsatellite status using next generation sequencing.
    Type: Application
    Filed: February 5, 2016
    Publication date: April 5, 2018
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Yongbao WANG, Kevin J. ARVAI, Daniel JONES
  • METHOD AND COMPOSITIONS FOR DETECTING AN ADENOMA-ADENOCARCINOMA TRANSITION IN CANCER
    Publication number: 20160341730
    Abstract: Methods and kits for detecting alternating spatial expression of PTEN and, optionally, SMAD4, CD44, and/or TP53 in colonic tumors are described. The methods and kits are useful for identifying a cancer stem cell (CSC)-like zone within a colonic tumor, identifying an adenoma-adenocarcinoma (Ad-ACA) transition zone in a colorectal cancer (CRC) tumor, identifying a CRC tumor that contains high-grade adenoma and/or early adenocarcinoma regions, identifying CSCs in a CRC tumor, diagnosing a subject with high-grade colon adenoma and/or early adenocarcinoma, and determining the likelihood that a colonic tumor in a subject will undergo invasive transformation if left untreated.
    Type: Application
    Filed: January 27, 2015
    Publication date: November 24, 2016
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Daniel Jones, Kevin J. Arvai, Ya-Hsuan Hsu