Abstract: Described herein are solid, pharmaceutical compositions, dosage forms and methods of making and using the same, wherein the solid compositions comprise at least one high viscosity agent. The solid, high viscosity agent-comprising pharmaceutical compositions, when comprised of an opioid drug, can reduce the potential for abuse of such drug. The solid dosage forms are characterized by having a significantly reduced extractability of an opioid drug comprised therein upon contact of the dosage form with a solvent such as a typical household solvent. The solid dosage forms, following contact with a household solvent, such as an aqueous or alcoholic solvent, generate a high viscosity solution, thereby discouraging abuse of the resulting formulation via intravenous (IV) injection.

Abstract: Peripherally-acting opioid antagonists can be orally administered to treat the side effects of opioid administration in convenient dosing schedules.

Abstract: A composition is provided for administration to a subject by way of a needleless syringe. The composition is formed from particles having a mean mass aerodynamic diameter of from 1 to 250 microns, and an envelope density of from 0.1 to 25 g/cm.sup.3, where the particles include a biologically active agent and a sustained-release material that controls release of the active agent to a subject following administration of the composition thereto. Methods for delivering a biologically active agent to a subject are also provided.

Abstract: Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% or less of the total dose of beneficial agent in the first 24 hours after implantation for local applications. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

Abstract: Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% or less of the total dose of beneficial agent in the first 24 hours after implantation for local applications. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

Abstract: Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% or less of the total dose of beneficial agent in the first 24 hours after implantation for local applications. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

Abstract: Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% or less of the total dose of beneficial agent in the first 24 hours after implantation for local applications. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

Abstract: An injectable depot gel composition containing a polymer, a solvent that can dissolve the polymer and thereby form a viscous gel, a beneficial agent; and an emulsifying agent in the form of a dispersed droplet phase in the viscous gel. The injectable depot gel composition can be prepared by mixing the polymer and the solvent so that the solvent dissolves the polymer and forms a viscous gel. The beneficial agent is dissolved or dispersed in the viscous gel and the emulsifying agent is mixed with the beneficial agent containing viscous gel. The emulsifying agent forms a dispersed droplet phase in the viscous gel to provide the injectable depot gel composition. The injectable depot gel composition can deliver a beneficial agent to a human or animal with a desired release profile.

Abstract: An injectable depot gel composition containing a polymer, a solvent that can dissolve the polymer and thereby form a viscous gel, a beneficial agent; and an emulsifying agent in the form of a dispersed droplet phase in the viscous gel. The injectable depot gel composition can be prepared by mixing the polymer and the solvent so that the solvent dissolves the polymer and forms a viscous gel. The beneficial agent is dissolved or dispersed in the viscous gel and the emulsifying agent is mixed with the beneficial agent containing viscous gel. The emulsifying agent forms a dispersed droplet phase in the viscous gel to provide the injectable depot gel composition. The injectable depot gel composition can deliver a beneficial agent to a human or animal with a desired release profile.

Abstract: Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% or less of the total dose of beneficial agent in the first 24 hours after implantation for local applications. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

Abstract: The invention provides a phase stable, thickened aqueous abrasive cleanser and a method for preparing it, said cleanser comprising:a) an effective amount of a cross-linked polyacrylate;b) an effective amount of at least one bleach-stable surfactant;c) an effective amount of a low salt, high purity hypochlorite;d) an effective amount of a pH-adjusting agent;e) an effective amount of abrasive; andf) the remainder as water.

Abstract: A method of making a hard surface abrasive scouring cleanser, in steps comprising making an aqueous solution of nonionic surfactant and pH adjusting agent; making a slurry of water and a calcium carbonate abrasive, and allowing the slurry to degas; adding the slurry of to the aqueous solution slowly with gentle mixing and allowing the resultant mixture to degas; and adding a quantity of cross-linked polyacrylate and any other adjunct ingredients. The cleanser has no significant syneresis, undue viscosity or yield stress increase, stably suspends abrasives, and has excellent rinsing characteristics.

Abstract: The invention provides a phase stable, thickened aqueous abrasive cleanser and a method for preparing it, said cleanser comprising:a) an effective amount of a cross-linked polyacrylate;b) an effective amount of at least one bleach-stable surfactant;c) an effective amount of a low salt, high purity hypochlorite;d) an effective amount of a pH-adjusting agent;e) an effective amount of abrasive; andf) the remainder as water.

Abstract: The invention is a hard surface abrasive scouring cleanser having no significant syneresis, undue viscosity or yield stress increase, stably suspends abrasives, and has excellent rinsing characteristics. Furthermore, the present invention provides a stably suspended abrasive scouring cleanser which uses relatively small amounts of surfactants, thus lowering the total cost of producing these cleansers. The lesser amount of surfactant also affords the cleanser a milder feel and lower unaesthetic surfactant odor, while also requiring lower levels of fragrance. The absence of solvents results in a less irritating product as well.In one aspect the invention comprises, in aqueous solution:(a) a cross-linked polyacrylate;(b) at least one nonionic surfactant;(c) a pH adjusting agent; and(d) a calcium carbonate abrasive.

Abstract: The present invention provides stable bleach activator granules comprising:(a) a peroxygen bleach activator having the structure: ##STR1## wherein R is C.sub.1-20 branched or straight chain alkyl, alkoxylated alkyl, cycloalkyl, alkenyl, aryl, substituted aryl, alkylaryl; R' and R" are independently H, C.sub.1-4 alkyl, aryl; and L is a leaving group;b) a pliable binding material selected from materials having a melting completion temperature of greater than about 40.degree. C.; andc) a solubilizing aid selected from the group consisting of magnesium sulfate, alkali aryl sulfonate, polyvinyl pyrrolidone or mixtures thereof.The invention can also include additional stiffeners, such as calcium or magnesium silicate, or silica.

Abstract: The present invention provides stable bleach activator granules comprising:a) a peroxygen bleach activator having the structure: ##STR1## wherein R is C.sub.1-20 branched or straight chain alkyl, alkoxylated alkyl, cycloalkyl, alkenyl, aryl, substituted aryl, alkylaryl; R' and R" are independently H, C.sub.1-4 alkyl, aryl; and L is a leaving group;b) a pliable binding material selected from materials having a melting completion temperature of greater than about 40.degree. C.; and, optionally,c) a filler material.These bleach activator granules are combined with a detergent base which contains an oxidant bleach to provide an activated oxidant detergent composition.

Abstract: The present invention provides stable bleach activator granules comprising:a) a peroxygen bleach activator having the structure: ##STR1## wherein R is C.sub.1-20 branched or straight chain alkyl, alkoxylated alkyl, cycloalkyl, alkenyl, aryl, substituted aryl, alkylaryl; R' and R" are independently H, C.sub.1-4 alkyl, aryl; and L is a leaving group;b) a pliable binding material selected from materials having a melting completion temperature of greater than about 40.degree. C.; and, optionally,c) a filler material.These bleach activator granules are combined with a detergent base which contains an oxidant bleach to provide an activated oxidant detergent composition.