Abstract: A sterile craniotomy drape and method of simultaneously draping a sterile barrier over a patient and a navigation tracker prior to performing a craniotomy procedure are provided. The sterile craniotomy drape has a flexible, sterile wall with opposite edges extending lengthwise between opposite ends. The wall is sized to substantially cover a patient lying on a patient support surface of an operating table. The wall has a cranial region adapted to be attached to the patients head and at least one opening adjacent the cranial region. A flexible, tubular sterile sleeve has an open end attached to the wall about the at least one opening. The sleeve extends away from the wall to a free end for receipt of a navigation tracker therein.