Patents by Inventor Kevin J. Gaffney

Kevin J. Gaffney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11786511
    Abstract: Disclosed herein are methods for increasing circulating mesenchymal stem cells by administering a compound having the general formula 1 as defined herein, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: October 17, 2023
    Assignee: University of Southern California
    Inventors: Kevin J. Gaffney, Kathleen E. Rodgers, Maira Soto, Michael Weinberg
  • Publication number: 20230248708
    Abstract: Methods for treating systemic lupus erythematosus (SLE) are disclosed, based on administering to a subject with SLE an amount effective to treat the subject of a polypeptide including antiogensin 1-7 (A(1-7)), Nle3A1-7, or a compound according to general formula 1.
    Type: Application
    Filed: March 3, 2023
    Publication date: August 10, 2023
    Inventors: Kevin J. Gaffney, Kathleen E. Rodgers, Maira Soto
  • Patent number: 11446285
    Abstract: Methods for treating systemic lupus erythematosus (SLE) are disclosed, based on administering to a subject with SLE an amount effective to treat the subject of a polypeptide including antiogensin 1-7 (A(1-7)), Nle3A 1-7, or a compound according to general formula.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: September 20, 2022
    Assignee: University of Southern California
    Inventors: Maira Soto, Kevin J. Gaffney, Kathleen E. Rodgers
  • Patent number: 10987403
    Abstract: Disclosed herein are compositions including cyclodextrin and Nle3-A(1-7) [Asp-Arg-Me-Tyr-Ile-His-Pro (SEQ ID NO: 1)] and their use in treating various disorders.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: April 27, 2021
    Assignee: University of Southern California
    Inventors: Kevin J. Gaffney, Stan G. Louie, Kathleen E. Rodgers
  • Publication number: 20200215037
    Abstract: Disclosed herein are methods for increasing circulating mesenchymal stem cells by administering a compound having the general formula 1 as defined herein, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 9, 2018
    Publication date: July 9, 2020
    Inventors: Kevin J. GAFFNEY, Kathleen E. RODGERS, Maira SOTO, Michael WEINBERG
  • Publication number: 20200206211
    Abstract: Methods for treating systemic lupus erythematosus (SLE) are disclosed, based on administering to a subject with SLE an amount effective to treat the subject of a polypeptide including antiogensin 1-7 (A(1-7)), Nle3A 1-7, or a compound according to general formula
    Type: Application
    Filed: June 7, 2018
    Publication date: July 2, 2020
    Inventors: Kevin J. GAFFNEY, Kathleen E. RODGERS, Maira SOTO
  • Publication number: 20200009212
    Abstract: Disclosed herein are compositions including cyclodextrin and Nle3-A(1-7) [Asp-Arg-Me-Tyr-Ile-His-Pro (SEQ ID NO: 1)] and their use in treating various disorders.
    Type: Application
    Filed: March 9, 2018
    Publication date: January 9, 2020
    Inventors: Kevin J. GAFFNEY, Stan G. LOUIE, Kathleen E. RODGERS
  • Patent number: 10301298
    Abstract: Disclosed are small molecule non-peptidic compounds, as well as methods and compositions for the treatment of angiotensin-related diseases and disorders, including cardiovascular diseases, metabolic diseases, gastrointestinal diseases, renal diseases, inflammatory/autoimmune diseases, neurological diseases, bone marrow diseases and cancer. In particular, the invention provides compounds, methods and compositions for the treatment of metabolic diseases and disorders, such as diabetes mellitus, diabetes-related cardiovascular disorders, diabetes-related dermal ulcerations, diabetes related hypertension, and diabetes-related ophthalmic diseases.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: May 28, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Nicos A. Petasis, Kathleen E. Rodgers, Stan G. Louie, Gere S. DiZerega, Kevin J. Gaffney
  • Patent number: 10195282
    Abstract: Described herein are compositions of alginate formulations that include water, divalent ions, and alginate cross-linked by the divalent ions, and their use for treating incisional wounds, such as intra-incisional application.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: February 5, 2019
    Assignee: University of Southern California
    Inventors: Kathleen E. Rodgers, Kevin J. Gaffney, Gere S. Dizerega
  • Patent number: 9943509
    Abstract: This invention provides methods, compounds and compositions for the treatment of musculoskeletal disease, muscle dysfunction, muscle-wasting disease or disorder, including hereditary myopathy, neuromuscular disease, muscular dystrophy, muscular atrophy, drug-induced myopathy, and related disease, disorder or condition that causes a decrease in muscle strength, comprising the use of heterocyclic non-peptidic compounds that act as Mas agonists and/or mimics of angiotensin 1-7.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: April 17, 2018
    Assignee: University of Southern California
    Inventors: Kevin J. Gaffney, Kathleen E. Rodgers, Stan G. Louie, Gere S. Dizerega, Nicos A. Petasis
  • Publication number: 20180030042
    Abstract: Disclosed are small molecule non-peptidic compounds, as well as methods and compositions for the treatment of angiotensin-related diseases and disorders, including cardiovascular diseases, metabolic diseases, gastrointestinal diseases, renal diseases, inflammatory/autoimmune diseases, neurological diseases, bone marrow diseases and cancer. In particular, the invention provides compounds, methods and compositions for the treatment of metabolic diseases and disorders, such as diabetes mellitus, diabetes-related cardiovascular disorders, diabetes-related dermal ulcerations, diabetes related hypertension, and diabetes-related ophthalmic diseases.
    Type: Application
    Filed: July 12, 2017
    Publication date: February 1, 2018
    Inventors: Nicos A. Petasis, Kathleen E. Rodgers, Stan G. Louie, Gere S. DiZerega, Kevin J. Gaffney
  • Publication number: 20170354736
    Abstract: Described herein are compositions of alginate formulations and their use for treating incisional wounds, such as intra-incisional application.
    Type: Application
    Filed: November 20, 2015
    Publication date: December 14, 2017
    Inventors: Kathleen E. RODGERS, Kevin J. GAFFNEY, Gere S. DIZEREGA
  • Patent number: 9732074
    Abstract: Disclosed are small molecule non-peptidic compounds, as well as methods and compositions for the treatment of angiotensin-related diseases and disorders, including cardiovascular diseases, metabolic diseases, gastrointestinal diseases, renal diseases, inflammatory/autoimmune diseases, neurological diseases, bone marrow diseases and cancer.
    Type: Grant
    Filed: March 15, 2014
    Date of Patent: August 15, 2017
    Assignee: University of Southern California
    Inventors: Nicos A. Petasis, Kathleen E. Rodgers, Stan G. Louie, Gere S. DiZerega, Kevin J. Gaffney
  • Publication number: 20170119748
    Abstract: This invention provides methods, compounds and compositions for the treatment of musculoskeletal disease, muscle dysfunction, muscle-wasting disease or disorder, including hereditary myopathy, neuromuscular disease, muscular dystrophy, muscular atrophy, drug-induced myopathy, and related disease, disorder or condition that causes a decrease in muscle strength, comprising the use of heterocyclic non-peptidic compounds that act as Mas agonists and/or mimics of angiotensin 1-7.
    Type: Application
    Filed: July 17, 2015
    Publication date: May 4, 2017
    Inventors: Kevin J. GAFFNEY, Kathleen E. RODGERS, Stan G. LOUIE, Gere S. DIZEREGA, Nicos A. PETASIS
  • Publication number: 20160016946
    Abstract: Disclosed are small molecule non-peptidic compounds, as well as methods and compositions for the treatment of angiotensin-related diseases and disorders, including cardiovascular diseases, metabolic diseases, gastrointestinal diseases, renal diseases, inflammatory/autoimmune diseases, neurological diseases, bone marrow diseases and cancer.
    Type: Application
    Filed: March 15, 2014
    Publication date: January 21, 2016
    Inventors: Nicos A. Petasis, Kathleen E. Rodgers, Stan G. Louie, Gere S. DiZerega, Kevin J. Gaffney