Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

Abstract: An apparatus for preventing neck injury, spinal cord injury and concussion is disclosed. The apparatus includes a helmet, a body harness and a plurality of anchor assemblies connecting the helmet to the body harness. The anchor assemblies are adjusted to limit the cervical rotation, lateral bending, flexion and extension ranges of motion of a wearer to a predetermined set point, each anchor assembly including a plurality of guide members extending from the helmet to an anchor of the anchor assembly, the plurality of guide members being attached to the anchor.

Abstract: An apparatus for preventing neck injury, spinal cord injury and concussion is disclosed. The apparatus includes a helmet, a body harness and a plurality of anchor assemblies connecting the helmet to the body harness. The anchor assemblies are adjustable to limit the cervical rotation, lateral bending, flexion and extension ranges of motion of a wearer to a predetermined set point, each anchor assembly including a plurality of guide cords extending from the helmet to an anchor of the anchor assembly, the plurality of guide cords being attached to, but individually adjustable with respect to, the anchor.

Abstract: An automatic syringe pump is disclosed that includes at least four subsystems: mechanical power, electronic timing, mechanical power transfer, and user interface subsystems. In some embodiments, an occlusion detection subsystem is also present. The mechanical power subsystem's main includes a constant force spring capable of storing the energy needed to reliable depressed several different sizes of a syringe. The electronic timing subsystem may include components including a ratchet, pawls, flippers, stepper motor, and microcontroller. These components are used together to regulated the release of the energy stored in the constant force spring. The mechanical power transfer subsystem may include components including a rack and pinion which translates the rotational motion of the drive shaft from the constant force spring into linear motion to depress the syringe. Finally, the user interface subsystem may include components including the microcontroller, Arduino backpack, and syringe tray.

Abstract: An apparatus for preventing neck injury, spinal cord injury and concussion is disclosed. The apparatus includes a helmet, a body harness and a plurality of anchor assemblies connecting the helmet to the body harness. The anchor assemblies are adjustable to limit the cervical rotation, lateral bending, flexion and extension ranges of motion of a wearer to a predetermined set point, each anchor assembly including a plurality of guide cords extending from the helmet to an anchor of the anchor assembly, the plurality of guide cords being attached to, but individually adjustable with respect to, the anchor.

Abstract: A variable sized diaper, which is reusable, is disclosed. The diaper inlcudes an outer liquid impermeable panel having a generally hourglass configuration. The outer panel is sealedly connected about its perimeter to a corresponding inner panel having a substantially identical outer perimeter. The inner panel includes a fluid absorbent core, longitudinally positioned along the length of the diaper which is circumscribed by a plurality of side panels and waist panels which are constructed of liquid impermeable fabric. A conjunction of the inner panel and the outer panel defines a liquid permeable absorbent core which is substantially surrounded by a fluid impermeable hollow pocket or sack which extends about the entire circumference of the absorbent core. A "V"-shaped pile attachment strip is positioned on the frontmost regions of the diaper and is adapted to connect with a pair of hook fasteners one of which is positioned on each of the two wing-like portions of the rear portion of the diaper.