Abstract: Affinity chromatography devices that include a fibrillated heat treated polymer membrane that contains inorganic particles having a spherical shape and a particle size distribution that has a D90/D10 less than or equal to 3 are disclosed. A blend or combination of spherical inorganic particles having a nominal particle size from about 5 microns to about 20 microns may be utilized. Also, the devices have a hydraulic permeability from about 200(×10?12 cm2) to about 700(×10?12 cm2). The affinity chromatography devices have a dynamic binding capacity (DBC) greater than 35 mg/ml at 10% breakthrough at a residence time of 20 seconds. Additionally, the affinity chromatography devices have a cycling durability of at least 100 cycles without exceeding an operating pressure of 0.3 MPa. Manifolds containing multiple affinity chromatography devices and manifolds in a parallel configuration are also disclosed.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a filter for removal of waste products from a dialysate. The filter may include multiple layers of one or more filter materials configured to allow dialysate to flow through the multiple layers.

Abstract: The present disclosure is directed to affinity chromatography devices including a fibrillated polymer membrane that contains inorganic particles having a spherical shape and a particle size distribution that has a D90/D10 less than or equal to 3. A blend or a combination of spherical inorganic particles may be utilized. A nominal particle size of the spherical inorganic particles is from about 5 microns to about 20 microns. An affinity ligand may be bonded to the spherical inorganic particles and/or to the fibrillated polymer membrane. Also, the affinity chromatography devices have a hydraulic permeability from about 100 (×10?12 cm2) to about 500 (×10?12 cm2). Additionally, the affinity chromatography devices have a cycling durability of at least 100 cycles without exceeding an pressure of 0.3 MPa. Manifolds containing multiple affinity chromatography devices in a parallel configuration and multiple manifolds in a parallel configuration are also disclosed.

Abstract: The present invention is directed to a thermally insulative material comprising PTFE, including an expanded PTFE (ePTFE), having a thermal conductivity of less than or equal to 25 mW/m K at atmospheric conditions. In one embodiment, the insulative material of the present invention includes aerogel particles and polytetrafluoroethylene (PTFE). The insulative material may be formed into articles that are hydrophobic, highly breathable, possess high strength, and which may be used in non-static applications such as dynamic flexing and the like. The insulative articles are flexible, stretchable, and bendable. Also, the insulative material has little to no shedding or dusting of fine particles. Aerogel particles having a particle density of less than about 100 kg/m3 and a thermal conductivity of less than or equal to about 15 mW/m K at atmospheric conditions (about 298.5 K and 101.3 kPa) may be used in the insulative material.

Abstract: Thermally insulative materials and articles are described. In one embodiment, the thermally insulative material comprises a polymer matrix, aerogel particles and expanded microspheres, wherein the aerogel particles are present in an amount of 30% by weight or greater, the polymer matrix is present in an amount of greater than or equal to 20% by weight and the expanded microspheres are present in an amount of 0.5% to 15% by weight, the percentages being based on the total weight of the polymer matrix, the aerogel particles and the expanded microspheres; and wherein the thermal conductivity of the thermally insulative material is less than 40 mW/m K at atmospheric conditions.

Abstract: The present invention is directed to a thermally insulative material comprising PTFE, including an expanded PTFE (ePTFE), having a thermal conductivity of less than or equal to 25 mW/m K at atmospheric conditions. In one embodiment, the insulative material of the present invention includes aerogel particles and polytetrafluoroethylene (PTFE). The insulative material may be formed into articles that are hydrophobic, highly breathable, possess high strength, and which may be used in non-static applications such as dynamic flexing and the like. The insulative articles are flexible, stretchable, and bendable. Also, the insulative material has little to no shedding or dusting of fine particles. Aerogel particles having a particle density of less than about 100 kg/m3 and a thermal conductivity of less than or equal to about 15 mW/m K at atmospheric conditions (about 298.5 K and 101.3 kPa) may be used in the insulative material.