Abstract: Disclosed are compositions and methods for sensitive detection of one or multiple analytes. In general, the methods involve the use of special label components, referred to as reporter signals, that can be associated with, incorporated into, or otherwise linked to the analytes. In some embodiments, the reporter signals can be altered such that the altered forms of different reporter signals can be distinguished from each other. In some embodiments, sets of reporter signals can be used where two or more of the reporter signals in a set have one or more common properties that allow the reporter signals having the common property to be distinguished and/or separated from other molecules lacking the common property.

Abstract: Disclosed are compositions and methods for sensitive detection of one or multiple analytes. In general, the methods involve the use of special label components, referred to as reporter signals, that can be associated with, incorporated into, or otherwise linked to the analytes. In some embodiments, the reporter signals can be altered such that the altered forms of different reporter signals can be distinguished from each other. In some embodiments, sets of reporter signals can be used where two or more of the reporter signals in a set have one or more common properties that allow the reporter signals having the common property to be distinguished and/or separated from other molecules lacking the common property.

Abstract: Thermoplastic, thermoshapable composite laminate bars, an orthopedic brace using the shaped composite bars as integral components, and a method of thermoshaping the composite bars for use as fitted components in the orthopedic brace are provided. The composite bars contain multiple fiber layers oriented in at least two directions with respect to the bar length to provide high flexural and torsional strength. The novel method of thermoshaping yields improved results over prior thermoshaping methods by providing an uncomplicated shaping capability while maintaining the structural and mechanical properties of the composite bar.

Abstract: Thermoplastic, thermoshapable composite laminate bars, an orthopedic brace using the shaped composite bars as integral components, and a method of thermoshaping the composite bars for use as fitted components in the orthopedic brace are provided. The composite bars contain multiple fiber layers oriented in at least two directions with respect to the bar length to provide high flexural and torsional strength. The novel method of thermoshaping yields improved results over prior thermoshaping methods by providing an uncomplicated shaping capability while maintaining the structural and mechanical properties of the composite bar.

Abstract: Polymer matrix composite materials containing a thermoplastic composite core bonded integrally with a fabric layer are provided. The fabric layer has a greater elasticity than the core, so that the fabric layer can conform smoothly to the core during thermoforming. This improvement has been demonstrated to improve aesthetic appearance and nearly eliminate wrinkling and distortion of the fabric layer when compared to conventional composite materials.