Abstract: The present disclosure relates to compounds of Formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, useful in the treatment of treating viral infections, for example, coronaviridae infections.

Abstract: Embodiments of the invention provide novel, industrially applicable, and non-obvious apparatus and methods for automatically, routinely, and accurately calibrating a trace detection portal. Embodiments of the apparatus include a calibrant container; a substance (or substances) uniquely identifiable by a trace detection portal as a calibrant; unique placement of the calibrant container's outlet relative to a substance collection port of a sample collection chamber; and/or computer executable instructions that, when executed by a computer processor, cause a consistent release of a measured amount of calibrant into the sample collection chamber upon command and/or at pre-determined time intervals.

Abstract: Embodiments of the invention provide novel, industrially applicable, and non-obvious apparatus and methods for automatically, routinely, and accurately calibrating a trace detection portal. Embodiments of the apparatus include a calibrant container; a substance (or substances) uniquely identifiable by a trace detection portal as a calibrant; unique placement of the calibrant container's outlet relative to a substance collection port of a sample collection chamber; and/or computer executable instructions that, when executed by a computer processor, cause a consistent release of a measured amount of calibrant into the sample collection chamber upon command and/or at pre-determined time intervals.

Abstract: The invention is directed to a trap material use in a chemical trace detection portal for detecting trace amounts of contraband, and more particularly for detecting vapors and particles emitted from drugs and explosive devices. The trap material is made of a metallic foam material, such as aluminum foam metal, copper foam metal, stainless steel foam metal, or a silica-carbon foam metal, which have high thermoconductivity and reduced density, as compared to conventional trap materials, thereby ensuring that the internal temperature of the subject trap rapidly achieves the temperature required during desorbing of the trace materials.

Abstract: A portal trace detection apparatus is provided for detecting minute particles of interest, such as traces of narcotics, explosives and other contraband. The apparatus includes a portal through which a human suspect will pass. A detection apparatus is disposed at least partly in the ceiling of the portal, and hence above the human subject in the portal. Particles of interest will be entrained in the human thermal plume that exists in the boundary layer of air adjacent the suspect, and will flow upwardly from the suspect to the detection apparatus in the ceiling of the portal. The portal includes a plurality of vertically aligned arrays of air jets. The air jets are fired sequentially from bottom to top to produce short bursts of air sufficient to disturb the clothing of the suspect and to dislodge particles of interest from the clothing. The dislodged particles of interest are entrained in the air in the human thermal plume and are transported upwardly to the detector.

Abstract: A detector requires a stream of dry air for transporting particles to the detector. The detector then operates to determine whether the dry air has transported any particles of interest. Continuous operation of the detector is permitted by providing first and second dryers that can be operated alternately for drying air that is to be directed to the detector. The dryer that is not being operated is recharged. Air is directed alternately between the first and second dryer to ensure that neither dryer is operated after reaching saturation.

Abstract: The invention is directed to a trap material use in a chemical trace detection portal for detecting trace amounts of contraband, and more particularly for detecting vapors and particles emitted from drugs and explosive devices. The trap material is made of a metallic foam material, such as aluminum foam metal, copper foam metal, stainless steel foam metal, or a silica-carbon foam metal, which have high thermoconductivity and reduced density, as compared to conventional trap materials, thereby ensuring that the internal temperature of the subject trap rapidly achieves the temperature required during desorbing of the trace materials.

Abstract: A detector requires a stream of dry air for transporting particles to the detector. The detector then operates to determine whether the dry air has transported any particles of interest. Continuous operation of the detector is permitted by providing first and second dryers that can be operated alternately for drying air that is to be directed to the detector. The dryer that is not being operated is recharged. Air is directed alternately between the first and second dryer to ensure that neither dryer is operated after reaching saturation.

Abstract: A portal trace detection apparatus is provided for detecting minute particles of interest, such as traces of narcotics, explosives and other contraband. The apparatus includes a portal through which a human suspect will pass. A detection apparatus is disposed at least partly in the ceiling of the portal, and hence above the human subject in the portal. Particles of interest will be entrained in the human thermal plume that exists in the boundary layer of air adjacent the suspect, and will flow upwardly from the suspect to the detection apparatus in the ceiling of the portal. The portal includes a plurality of vertically aligned arrays of air jets. The air jets are fired sequentially from bottom to top to produce short bursts of air sufficient to disturb the clothing of the suspect and to dislodge particles of interest from the clothing. The dislodged particles of interest are entrained in the air in the human thermal plume and are transported upwardly to the detector.

Abstract: A portal trace detection apparatus is provided for detecting minute particles of interest, such as traces of narcotics, explosives and other contraband. The apparatus includes a portal through which a human suspect will pass. A detection apparatus is disposed at least partly in the ceiling of the portal, and hence above the human subject in the portal. Particles of interest will be entrained in the human thermal plume that exists in the boundary layer of air adjacent the suspect, and will flow upwardly from the suspect to the detection apparatus in the ceiling of the portal. The portal includes a plurality of vertically aligned arrays of air jets. The air jets are fired sequentially from bottom to top to produce short bursts of air sufficient to disturb the clothing of the suspect and to dislodge particles of interest from the clothing. The dislodged particles of interest are entrained in the air in the human thermal plume and are transported upwardly to the detector.