Patents by Inventor Kevin J. Tracey

Kevin J. Tracey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10799628
    Abstract: A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: October 13, 2020
    Assignee: DEKA Products Limited Partnership
    Inventors: Michael J. Wilt, Kevin L. Grant, James D. Dale, Jason A. Demers, Brian D. Tracey
  • Patent number: 10780213
    Abstract: A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: September 22, 2020
    Assignee: DEKA Products Limited Partnership
    Inventors: Kevin L. Grant, Michael J. Wilt, Brian D. Tracey, Brett A. Rudolf, David E. Collins, Lisa A. Gustin, James D. Dale, Jesse T. Bodwell
  • Publication number: 20200282124
    Abstract: A blood circuit assembly for a dialysis unit may include an organizing tray, a pair of pneumatic pumps mounted to the organizing tray for circulating blood received from a patient through a circuit including a dialyzer unit and returned to the patient, an air trap mounted to the organizing tray arranged to remove air from blood circulating in the circuit, a pair of dialyzer connections arranged to connect to the inlet and outlet of a dialyzer unit, and a pair of blood line connectors, one inlet blood line connector for receiving blood from the patient and providing blood to the pneumatic pumps and the other outlet blood line connector for returning blood to the patient.
    Type: Application
    Filed: December 9, 2019
    Publication date: September 10, 2020
    Applicant: DEKA Products Limited Partnership
    Inventors: Kevin L. Grant, James D. Dale, Michael J. Wilt, Jason A. Demers, David E. Collins, Brian D. Tracey
  • Publication number: 20200206310
    Abstract: Methods of treating sepsis or endotoxemia in a subject comprising administering to the subject an amount of an antagonist of a Panx1 hemichannel protein or an amount of an antagonist of a Cx43 hemichannel protein.
    Type: Application
    Filed: January 16, 2020
    Publication date: July 2, 2020
    Inventors: Haichao Wang, Wei Li, Kevin J. Tracey, Ping Wang
  • Publication number: 20200191132
    Abstract: A pump cassette is disclosed. The pump cassette includes a housing having at least one fluid inlet line and at least one fluid outlet line. The cassette also includes at least one reciprocating pressure displacement membrane pump within the housing. The pressure pump pumps a fluid from the fluid inlet line to the fluid outlet line. A hollow spike is also included on the housing as well as at least one metering pump. The metering pump is fluidly connected to the hollow spike on the housing and to a metering pump fluid line. The metering pump fluid line is fluidly connected to the fluid outlet line.
    Type: Application
    Filed: September 17, 2019
    Publication date: June 18, 2020
    Applicant: DEKA Products Limited Partnership
    Inventors: Jason A. Demers, Michael J. Wilt, Kevin L. Grant, James D. Dale, Brian D. Tracey
  • Publication number: 20200190159
    Abstract: A method of treating a disease or reducing the development of a symptom of a disease in a subject by administering to the subject an amount of tetranectin protein or a tetranectin peptide agonist effective to treat or reduce development of the disease or disease symptom.
    Type: Application
    Filed: June 4, 2018
    Publication date: June 18, 2020
    Inventors: Haichao Wang, Wei Li, Jianhua Li, Kevin J. Tracey
  • Publication number: 20200179600
    Abstract: The present disclosure relates to systems, methods and devices to monitor, diagnose and/or treat diseases or disorders comprising a calibration phase and a real-time diagnostic, treatment or monitoring phase, the calibration phase correlating a plurality of nerve activity measurements from a chronically implanted electrode in a subject with a plurality of concurrent measurements of levels of cytokines and/or glucose in the blood to obtain a functional relationship between blood cytokine and/or glucose levels and vagus nerve activity, and the diagnostic, treatment or monitoring phase analyzing the subject's real-time vagus nerve activity in accordance with the previously obtained functional relationship to initiate a treatment method.
    Type: Application
    Filed: April 19, 2018
    Publication date: June 11, 2020
    Applicant: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Theodoros Zanos, Todd Levy, Emily Battinelli, Kevin J. Tracey, Chad E. Bouton, Sangeeta Chavan, Harold Silverman
  • Publication number: 20200171226
    Abstract: Automated control mechanisms and methods for controlling fluid flow in a hemodialysis apparatus are described. The methods can involve a controller receiving information from a pressure sensor in a control chamber of a reciprocating diaphragm-based blood pump and causing the application of a time-varying pressure waveform on a diaphragm of the blood pump during a fill-stroke of the blood pump. The controller can be configured and programmed to monitor a pressure variation in the control chamber measured by the pressure sensor and to compare the measured pressure variation to a pre-determined value. Based on such comparison, the controller can initiate a procedure to pause or stop a dialysate pump of the hemodialysis apparatus if the magnitude of the measured pressure variation deviates from the pre-determined value.
    Type: Application
    Filed: December 20, 2019
    Publication date: June 4, 2020
    Applicant: DEKA Products Limited Partnership
    Inventors: Michael J. Wilt, Dirk A. van der Merwe, James D. Dale, Brian D. Tracey, Kevin L. Grant, Jason A. Demers, Catharine N. Flynn
  • Publication number: 20200139031
    Abstract: Systems for monitoring fluid flow in an extracorporeal blood circuit are described. The blood circuit of such systems can include plod pump having a pumping chamber of the blood pump separated from a control chamber of the blood pump by a flexible diaphragm. The control chamber can be configured to transmit positive or negative pressure to operate the diaphragm. The system can include a pressure sensor configured to measure pressure in the control chamber of the blood pump, and a controller configured to receive information from the pressure sensor and to control the delivery of pressure to the control chamber of the blood pump. The controller can also be configured to cause the application of a time-varying pressure waveform on the blood pump diaphragm during a fill-stroke of the blood pump, and to monitor a pressure variation in the control chamber measured by the pressure sensor.
    Type: Application
    Filed: December 20, 2019
    Publication date: May 7, 2020
    Applicant: DEKA Products Limited Partnership
    Inventors: Michael J. Wilt, Dirk A. Van der Merwe, James D. Dale, Brian D. Tracey, Kevin L. Grant, Jason A. Demers, Catherine N. Flynn
  • Publication number: 20200101293
    Abstract: Methods are disclosed for treating a subject having a disease or disorder comprising stimulating a nerve of the subject with a corrective stimulus pattern derived from a disease-specific, condition-specific, endogenous mediator-specific or pharmacologic agent-specific neurogram in an amount and manner effective to treat the disease or disorder.
    Type: Application
    Filed: November 26, 2019
    Publication date: April 2, 2020
    Applicant: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Kevin J. Tracey, Sangeeta S. Chavan
  • Publication number: 20200086035
    Abstract: Hemodialysis systems are described. A hemodialysis system may include a dialysate flow path through which dialysate is passed from a dialysate reservoir, which includes a valved vent to atmosphere, to an ultrafilter. The dialysate flow path includes a pneumatically actuated diaphragm-based dialysate pump for pumping fluid from the dialysate reservoir to the ultrafilter. The hemodialysis system may include a controller for controlling pneumatic actuation pressure delivered to the dialysate pump and at least one valve connecting the dialysate reservoir vent to the atmosphere. The hemodialysis system may be configured to actuate the dialysate pump and the at least one valve to introduce air into the dialysate flow path and expel liquid from the dialysate flow path to a drain.
    Type: Application
    Filed: October 21, 2019
    Publication date: March 19, 2020
    Applicant: DEKA Products Limited Partnership
    Inventors: MICHAEL J. WILT, Jason A. Demers, Kevin L. Grant, Brian D. Tracey, James D. Dale
  • Patent number: 10561846
    Abstract: A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.
    Type: Grant
    Filed: December 23, 2018
    Date of Patent: February 18, 2020
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Kevin J. Tracey, Jared M. Huston
  • Publication number: 20200046992
    Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of tissue that include applying energy (e.g., electromagnetic energy) into the target tissue to cause altered activity of a neuron in the tissue. In certain embodiments, the altered activity causes a change in one or molecules in the tissue or blood.
    Type: Application
    Filed: October 31, 2017
    Publication date: February 13, 2020
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Kevin J. Tracey, Sangeeta S. Chavan, Chad E. Bouton
  • Patent number: 10548949
    Abstract: Methods of treating sepsis or endotoxemia in a subject comprising administering to the subject an amount of an antagonist of a Panx1 hemichannel protein or an amount of an antagonist of a Cx43 hemichannel protein.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: February 4, 2020
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Haichao Wang, Wei Li, Kevin J. Tracey, Ping Wang
  • Patent number: 10537671
    Abstract: A hemodialysis apparatus comprising diaphragm pumps for the movement of both dialysate and blood, and under the control of a controller, is capable of detecting blood flow conditions that give rise to an alarm and implement procedures to adjust, pause, or halt the pumping of dialysate and/or blood. The controller can direct the application of a time-varying pressure to fluid in the control chamber of a blood pump, and monitor the resulting pressure waveform during a fill stroke of the blood pump. A deviation of the measured pressure variation from an expected value can give rise to an alert to a user and to the initiation of an adjustment, pause, or cessation of the dialysate pump's activity.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: January 21, 2020
    Assignee: DEKA Products Limited Partnership
    Inventors: Michael J. Wilt, Dirk A. van der Merwe, James D. Dale, Brian D. Tracey, Kevin L. Grant, Jason A. Demers, Catharine N. Flynn
  • Patent number: 10507327
    Abstract: Methods are disclosed for treating a subject having a disease or disorder comprising stimulating a nerve of the subject with a corrective stimulus pattern derived from a disease-specific, condition-specific, endogenous mediator-specific or pharmacologic agent-specific neurogram in an amount and manner effective to treat the disease or disorder.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: December 17, 2019
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Kevin J. Tracey, Sangeeta S. Chavan
  • Patent number: 10500327
    Abstract: A blood circuit assembly for a dialysis unit may include an organizing tray, a pair of pneumatic pumps mounted to the organizing tray for circulating blood received from a patient through a circuit including a dialyzer unit and returned to the patient, an air trap mounted to the organizing tray arranged to remove air from blood circulating in the circuit, a pair of dialyzer connections arranged to connect to the inlet and outlet of a dialyzer unit, and a pair of blood line connectors, one inlet blood line connector for receiving blood from the patient and providing blood to the pneumatic pumps and the other outlet blood line connector for returning blood to the patient.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: December 10, 2019
    Assignee: DEKA Products Limited Partnership
    Inventors: Kevin L. Grant, James D. Dale, Michael J. Wilt, Jason A. Demers, David E. Collins, Brian D. Tracey
  • Publication number: 20190321623
    Abstract: Disclosed are apparatuses and methods for reducing or limiting bleeding (e.g., blood loss and/or bleeding time) in an animal by trigeminal stimulation. The apparatuses and methods may activate one or more branches of the trigeminal nerve. This activation may be invasive or non-invasive.
    Type: Application
    Filed: April 22, 2019
    Publication date: October 24, 2019
    Inventors: Jared M. HUSTON, Jason R. FRITZ, Seema G. AMIN, Christopher J. CZURA, Kevin J. TRACEY
  • Patent number: 10449280
    Abstract: Disclosed are hemodialysis and similar dialysis systems including fluid flow circuits. Hemodialysis systems may include a blood flow path, and a dialysate flow path including balancing, mixing, and/or a directing circuits. Preparation of dialysate may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit and/or the various fluid flow paths may be isolated from electrical components. A gas supply may be provided that, when activated, is able to urge dialysate through the dialyzer and blood back to the patient. Such a system may be useful during a power failure. The hemodialysis system may also include fluid handling devices, such as pumps, valves, mixers, etc., actuated using a control fluid. The control fluid may be delivered to the fluid handling devices using a detachable external pump. The fluid handling devices may have a spheroid shape with a diaphragm dividing it into two compartments.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: October 22, 2019
    Assignee: DEKA Products Limited Partnership
    Inventors: Michael J. Wilt, Jason A. Demers, Kevin L. Grant, Brian D. Tracey, James D. Dale
  • Patent number: 10443591
    Abstract: Hemodialysis and similar dialysis systems including a variety of systems and methods that make hemodialysis more efficient, easier, and/or more affordable, and include new fluid circuits for fluid flow in hemodialysis systems and a blood pump. The blood pump is configured to pump blood to a dialyzer of a hemodialysis apparatus and comprises a pneumatically actuated or controlled reciprocating diaphragm pump. The diaphragm of the pump comprises a flexible membrane formed or molded to conform to a curved inner wall of a pumping chamber or control chamber of the pump, and the diaphragm is pre-formed or molded to have a control side taking a convex shape, so that any elastic tension on the diaphragm is minimized when fully extended into a control chamber of the pump.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: October 15, 2019
    Assignee: DEKA Products Limited Partnership
    Inventors: Michael J. Wilt, James D. Dale, Brian D. Tracey, Kevin L. Grant, Jason A. Demers