Abstract: A manhole lock system includes a frame positioned over an access opening, a cover movable between a closed position in which the cover extends over the access opening, and an open position in which the access opening is exposed; and a lock mechanism for locking the cover in the closed position. The lock mechanism includes a lock member that is movable along a path between a unlocked position and a locked position, wherein in the locked position the lock member prevents the cover from moving to the open position, wherein in the unlocked position the lock member is retracted to enable movement of the cover to the open position.

Abstract: Provided herein are EpCAM binding proteins, pharmaceutical compositions comprising such proteins or fragments thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such EpCAM binding proteins. Also disclosed are methods of using the disclosed EpCAM binding proteins in the prevention, and/or treatment diseases, conditions and disorders.

Abstract: A manhole lock system includes a frame positioned over an access opening, a cover movable between a closed position in which the cover extends over the access opening, and an open position in which the access opening is exposed; and a lock mechanism for locking the cover in the closed position. The lock mechanism includes a lock member that is movable along a path between a unlocked position and a locked position, wherein in the locked position the lock member prevents the cover from moving to the open position, wherein in the unlocked position the lock member is retracted to enable movement of the cover to the open position.

Abstract: The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.

Abstract: The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.

Abstract: The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.

Abstract: A controlled pressure release vault panel assembly is capable of functioning as a second, or auxiliary, relief port to allow the escape of fluid from the vault in the event of pressure build-up inside the vault or in an explosion event. The vault panel assembly may define an opening that includes a manhole cover assembly. The manhole cover assembly may also be vented, and may function as a primary vent. The vault panel assembly may include a retention assembly extending from the vault panel underneath a portion of the vault, enabling a limited range of motion of the vault panel for the escape of fluid and allowing the reseating of the vault pane on the vault once the pressure inside the vault approaches ambient pressures.

Abstract: A controlled pressure release vault panel assembly is capable of functioning as a second, or auxiliary, relief port to allow the escape of fluid from the vault in the event of pressure build-up inside the vault or in an explosion event. The vault panel assembly may define an opening that includes a manhole cover assembly. The manhole cover assembly may also be vented, and may function as a primary vent. The vault panel assembly may include a retention assembly extending from the vault panel underneath a portion of the vault, enabling a limited range of motion of the vault panel for the escape of fluid and allowing the reseating of the vault pane on the vault once the pressure inside the vault approaches ambient pressures.

Abstract: The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.

Abstract: A fire hydrant having a valve seat flange with an integral liner. In one embodiment, the fire hydrant includes a valve seat flange disposed between a standpipe and a hydrant shoe. The valve seat flange includes a standpipe neck defining internal threads to directly connect to the standpipe and a base flange to directly connect to the hydrant shoe. The liner includes an outer peripheral edge that is entrapped within the valve seat flange and an inner circumferential surface defining threads for receiving the valve seat of a valve assembly. The present invention also discloses a process of manufacturing a valve seat flange, including the steps of: (a) manufacturing the liner, (b) incorporating the liner into a core with the outer peripheral region of the liner exposed, (c) placing the integral core/liner into the valve seat flange mold and (d) forming the valve seat flange around the liner with the valve seat flange entrapping the outer peripheral region of the liner.

Abstract: An air shield for partially enclosing the forward end of a ladder such that the ladder can more easily and efficiently be carried on the top of vehicles which shield includes an aerodynamic outer shell and an interior of yieldable cushioning material which reduces ladder rattle and vibration.