Abstract: Provided herein is a disinfecting device including a container containing a chlorhexidine-based solution having a chlorhexidine concentration of from 0.2-2.0% wt/vol. Provided also is a medical connector disinfected with the disinfecting device. A method of disinfecting a medical connector using the disinfecting device is also disclosed.

Abstract: The present disclosure provides chimeric antigen receptors, compostions, and methods thereof. In one embodiment the present disclosure provides a method of treating autoimmune diseases, asthma, and preventing or mediating organ rejection in a subject.

Abstract: Conventional email filtering services are not suitable for recognizing sophisticated malicious emails, and therefore may allow sophisticated malicious emails to reach inboxes by mistake. Introduced here are threat detection platforms designed to take an integrative approach to detecting security threats. For example, after receiving input indicative of an approval from an individual to access past email received by employees of an enterprise, a threat detection platform can download past emails to build a machine learning (ML) model that understands the norms of communication with internal contacts (e.g., other employees) and/or external contacts (e.g., vendors). By applying the ML model to incoming email, the threat detection platform can identify security threats in real time in a targeted manner.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: The present disclosure provides chimeric anti-gen receptor polypeptides having antigen recognition domains for CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens, and polynucleotides encoding for the same. The present disclosure also provides for engineered cells expressing the poly-nucleotide or polypeptides. In some embodiments, the disclosure provides methods for treating diseases associated with CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens.

Abstract: In some implementations, a user device can coordinate adjustments to a composite GUI generated in cooperation with an accessory device that presents the composite graphical user interface. For example, the user device can receive configuration data that defines the maximum GUI display area (e.g., size, dimensions) of the accessory device, various view areas within the GUI display area of the accessory device into which the user device can render GUIs, and/or transitions between the various view areas. The user device can generate a display buffer based on the maximum GUI display area, generate a graphical user interface in an area of the buffer corresponding to a current view area specified by the accessory device, and send to the accessory device video frames corresponding to the display buffer. The accessory device can generate a composite GUI based on the received video frames that include the user device generated GUI.

Abstract: An apparatus to facilitate hardware enhancements for double precision systolic support is disclosed. The apparatus includes matrix acceleration hardware having double-precision (DP) matrix multiplication circuitry including a multiplier circuits to multiply pairs of input source operands in a DP floating-point format; adders to receive multiplier outputs from the multiplier circuits and accumulate the multiplier outputs in a high precision intermediate format; an accumulator circuit to accumulate adder outputs from the adders with at least one of a third global source operand on a first pass of the DP matrix multiplication circuitry or an intermediate result from the first pass on a second pass of the DP matrix multiplication circuitry, wherein the accumulator circuit to generate an accumulator output in the high precision intermediate format; and a down conversion and rounding circuit to down convert and round an output of the second pass as final result in the DP floating-point format.

Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4A, R4b, and R5, are as defined herein, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of CLL.

Abstract: An apparatus to facilitate supporting vector multiply add with double accumulator access in a graphics environment is disclosed. The apparatus includes a processor comprising processing resources, the processing resources comprising multiplier circuitry to: receive operands for a matrix multiplication operation, wherein the operands comprising two source matrices to be multiplied as part of the matrix multiplication operation; and issue a multiply and add vector (MADV) instruction for the multiplication operation utilizing a double accumulator access output, wherein the MADV instruction to multiply two vectors of the two source matrices in a single floating point (FP) pipeline of the processor.

Abstract: The present invention relates to innovative means of DNA sequence editing involving in-situ cut-and-paste (iCAP) or alternatively cut-and-paste in-situ (CAPi). Thus, in various embodiments described herein, the methods of the invention relate to methods of generating paired-end nucleic acid fragment sharing common linker nucleic acid sequences using a nicking endonuclease, a T7 endonuclease, a restriction enzyme or a transposase, methods of analyzing the nucleotides sequences from the linked-paired-end sequenced fragments and methods of de novo whole genome mapping.

Abstract: Methods, systems, and computer program products for automated scotopic adaptation are provided herein. A computer-implemented method includes measuring ambient illumination levels associated with at least one user over a first period of time; measuring illumination intensity levels generated by one or more illumination source devices during at least a portion of the first period of time; generating a scotopic adaptation model associated with the at least one user by processing at least a portion of the measured ambient illumination levels in conjunction with processing at least a portion of the measured illumination intensity levels; and automatically adjusting one or more illumination intensity levels generated by at least a portion of the one or more illumination source devices based at least in part on the scotopic adaptation model and one or more ambient illumination levels associated with the at least one user detected over a second period of time.

Abstract: A method for designing a phased-array antenna embedded into stacked high impedance surfaces (HIS) structure is proposed. The stacked HIS structure comprises a plurality of HIS cell, which has two plate layers with adjustable height of the lower layer. Each HIS cell has a corresponding LC tank structure. Under a given height (HIS cell volume), the overall capacitance increases when the height of the lower layer plate increases. By adjusting the height of the lower layer plate, a variable capacitance of the corresponding LC tank can be achieved to allow lower operation frequencies of the phased-array antenna and to realize the benefit of HIS in band of interest. In addition, different design conditions can be achieved for the phased-array antenna.

Abstract: Methods, systems, and computer program products for automated scotopic adaptation are provided herein. A computer-implemented method includes measuring ambient illumination levels associated with at least one user over a first period of time; measuring illumination intensity levels generated by one or more illumination source devices during at least a portion of the first period of time; generating a scotopic adaptation model associated with the at least one user by processing at least a portion of the measured ambient illumination levels in conjunction with processing at least a portion of the measured illumination intensity levels; and automatically adjusting one or more illumination intensity levels generated by at least a portion of the one or more illumination source devices based at least in part on the scotopic adaptation model and one or more ambient illumination levels associated with the at least one user detected over a second period of time.

Abstract: The disclosed computer-implemented method for preventing loss of possession factors may include (i) identifying an account of a user that is associated with a possession factor that is used by the user to perform a multi-factor authentication procedure that is required when accessing the account of the user, (ii) monitoring one or more attributes of at least one of the user and the possession factor, (iii) determining, based at least in part on the one or more attributes of at least one of the user and the possession factor, that the possession factor has likely been lost, and (iv) performing a security action in response to determining that the possession factor has likely been lost to prevent the user from being unable to perform the multi-factor authentication procedure. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A NAT system is identified as operating in conjunction with a specific IP address, in response to a threshold number of different authenticated computing devices making requests to the web service from the specific IP address during a given time period. The total number of computing devices operating from behind the identified NAT system is estimated, based on how many separate authenticated computing devices make requests to the web service from the IP address during the period of time. When a NAT system is identified, one or more additional action(s) are taken to manage the processing of traffic originating from the specific IP address, taking into account that multiple computing devices are operating behind the identified NAT system. An example action is rate limiting.

Abstract: The disclosed computer-implemented method for selecting questions for knowledge-based authentication based on social entropy may include (1) identifying a potential question to ask a user of a computing system during a KBA process in an attempt to verify the user's identity, (2) determining whether any information suggestive of a correct answer to the potential question is available to anyone other than the user of the computing system, (3) calculating a social entropy of the potential question based at least in part on the determination of whether any information suggestive of the correct answer is available to anyone other than the user, and then (4) selecting the potential question to be asked to the user during the KBA process based at least in part on the social entropy of the potential question. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A computer-implemented method for providing security in smart buildings may include (1) detecting the presence of a user in a smart building, (2) determining that the user is unauthorized to access at least one resource in a smart building network within the smart building, (3) in response to determining that the user is unauthorized to access the resource in the smart building network, selecting an authentication policy that provides heightened security within the smart building network, and (4) increasing security within the smart building network to reflect the presence of the user by implementing the authentication policy within the smart building network. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The disclosed computer-implemented method for using vehicles as information sources for knowledge-based authentication may include (1) identifying a vehicle belonging to a user who is attempting to authenticate with an identity-verification authority, (2) acquiring analytic information about the vehicle, (3) generating, by analyzing the analytic information about the vehicle, at least one authentication question, where the correct response to the authentication question requires knowledge about the vehicle, (4) presenting the authentication question to the user, and (5) authenticating the identity of the user based on the user responding correctly to the authentication question. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The disclosed computer-implemented method for detecting network security deficiencies on endpoint devices may include (i) detecting, at a network device, a request from an endpoint device to automatically connect to a wireless network, (ii) establishing, via the network device, a network connection between the endpoint device and a wireless network that appears to be the wireless network requested by the endpoint device but is not actually the requested wireless network, (iii) determining, based on establishing the network connection between the endpoint device and the wireless network that appears to be the requested wireless network, that the endpoint device is vulnerable to network attacks, and then (iv) facilitating, via the network connection, a security action on the endpoint device to protect the endpoint device against the network attacks. Various other methods, systems, and computer-readable media are also disclosed.