Abstract: Disclosed herein are teat dip compositions, comprising a) a fermentation derived mixture that include low molecular weight protein component; b) an emollient; c) one or more surfactants; and d) an anti-microbial agent. The disclosed methods provide for preventing milk contamination and associated bacterial infections of the teat in dairy animals, the method comprises applying to the teat of the dairy animal a composition, comprising: a) a fermentation derived mixture that include low molecular weight protein component; b) an emollient; c) one or more surfactants; and d) an anti-microbial agent, wherein the application is effective in treating mastitis of the teat, and wherein the composition is gentle on the teat tissue.