Patents by Inventor Kevin John Kauffman

Kevin John Kauffman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALKENYL SUBSTITUTED 2,5-PIPERAZINEDIONES, COMPOSITIONS, AND USES THEREOF
    Publication number: 20230338577
    Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
    Type: Application
    Filed: May 2, 2023
    Publication date: October 26, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
  • Poly(beta-amino esters) and uses thereof
    Patent number: 11696953
    Abstract: Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.
    Type: Grant
    Filed: September 7, 2022
    Date of Patent: July 11, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Kevin John Kauffman, James C. Kaczmarek, Asha Kumari Patel
  • Alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
    Patent number: 11679165
    Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: June 20, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
  • Polymer-lipids and compositions
    Patent number: 11608412
    Abstract: The present disclosure relates to improvements in the selection and formulation of PBAE polymers using a design of experiment approach, in which statistical methods are used to limit possible experimental conditions. The present disclosure relates to improved PBAE polymers and formulations.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: March 21, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: James C. Kaczmarek, Daniel Griffith Anderson, Luke Hyunsik Rhym, Kevin John Kauffman, Asha Kumari Patel
  • POLY (BETA-AMINO ESTERS) AND USES THEREOF
    Publication number: 20230061974
    Abstract: Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.
    Type: Application
    Filed: September 7, 2022
    Publication date: March 2, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Kevin John Kauffman, James C. Kaczmarek, Asha Kumari Patel
  • Poly (beta-amino esters) and uses thereof
    Patent number: 11464860
    Abstract: Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: October 11, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Kevin John Kauffman, James C. Kaczmarek, Asha Kumari Patel
  • ALKENYL SUBSTITUTED 2,5-PIPERAZINEDIONES, COMPOSITIONS, AND USES THEREOF
    Publication number: 20200353099
    Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
    Type: Application
    Filed: May 20, 2020
    Publication date: November 12, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
  • Alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
    Patent number: 10695444
    Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: June 30, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
  • POLYMER-LIPIDS AND COMPOSITIONS
    Publication number: 20200172663
    Abstract: The present disclosure relates to improvements in the selection and formulation of PBAE polymers using a design of experiment approach, in which statistical methods are used to limit possible experimental conditions. The present disclosure relates to improved PBAE polymers and formulations.
    Type: Application
    Filed: October 25, 2019
    Publication date: June 4, 2020
    Inventors: James C. Kaczmarek, Daniel Griffith Anderson, Luke Hyunsik Rhym, Kevin John Kauffman, Asha Kumari Patel
  • ALKENYL SUBSTITUTED 2,5-PIPERAZINEDIONES, COMPOSITIONS, AND USES THEREOF
    Publication number: 20190240349
    Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
    Type: Application
    Filed: February 6, 2019
    Publication date: August 8, 2019
    Inventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
  • POLY (BETA-AMINO ESTERS) AND USES THEREOF
    Publication number: 20190125874
    Abstract: Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.
    Type: Application
    Filed: October 25, 2018
    Publication date: May 2, 2019
    Inventors: Daniel Griffith Anderson, Kevin John Kauffman, James C. Kaczmarek, Asha Kumari Patel
  • Alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
    Patent number: 10201618
    Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: February 12, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
  • ALKENYL SUBSTITUTED 2,5-PIPERAZINEDIONES, COMPOSITIONS, AND USES THEREOF
    Publication number: 20160367686
    Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
    Type: Application
    Filed: June 17, 2016
    Publication date: December 22, 2016
    Inventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan