Patents by Inventor Kevin John Phillips
Kevin John Phillips has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10407474Abstract: Aggregation is a major cause of the misbehavior of proteins. A system for modifying a protein to create a more stable variant is provided. The method involves identifying non-conserved hydrophobic amino acid residues on the surface of a protein, suitable for mutating to more hydrophilic residues (e.g., charged amino acids). Any number of residues on the surface may be changed to create a variant that is more soluble, resistant to aggregation, has a greater ability to re-fold, and/or is more stable under a variety of conditions. The invention also provides GFP, streptavidin, and GST variants with an increased theoretical net charge created by the inventive technology. Kits are also provided for carrying out such modifications on any protein of interest.Type: GrantFiled: September 2, 2016Date of Patent: September 10, 2019Assignee: President and Fellows of Harvard CollegeInventors: David R. Liu, Kevin John Phillips, Michael S. Lawrence
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Publication number: 20170088592Abstract: Aggregation is a major cause of the misbehavior of proteins. A system for modifying a protein to create a more stable variant is provided. The method involves identifying non-conserved hydrophobic amino acid residues on the surface of a protein, suitable for mutating to more hydrophilic residues (e.g., charged amino acids). Any number of residues on the surface may be changed to create a variant that is more soluble, resistant to aggregation, has a greater ability to re-fold, and/or is more stable under a variety of conditions. The invention also provides GFP, streptavidin, and GST variants with an increased theoretical net charge created by the inventive technology. Kits are also provided for carrying out such modifications on any protein of interest.Type: ApplicationFiled: September 2, 2016Publication date: March 30, 2017Applicant: President and Fellows of Harvard CollegeInventors: David R. Liu, Kevin John Phillips, Michael S. Lawrence
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Patent number: 9434774Abstract: Aggregation is a major cause of the misbehavior of proteins. A system for modifying a protein to create a more stable variant is provided. The method involves identifying non-conserved hydrophobic amino acid residues on the surface of a protein, suitable for mutating to more hydrophilic residues (e.g., charged amino acids). Any number of residues on the surface may be changed to create a variant that is more soluble, resistant to aggregation, has a greater ability to re-fold, and/or is more stable under a variety of conditions. The invention also provides GFP, streptavidin, and GST variants with an increased theoretical net charge created by the inventive technology. Kits are also provided for carrying out such modifications on any protein of interest.Type: GrantFiled: December 30, 2011Date of Patent: September 6, 2016Assignee: President and Fellows of Harvard CollegeInventors: David R. Liu, Kevin John Phillips, Michael S. Lawrence
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Patent number: 9150626Abstract: Aggregation is a major cause of the misbehavior of proteins. A system for modifying a protein to create a more stable variant is provided. The method involves identifying non-conserved hydrophobic amino acid residues on the surface of a protein, suitable for mutating to more hydrophilic residues (e.g., charged amino acids). Any number of residues on the surface may be changed to create a variant that is more soluble, resistant to aggregation, has a greater ability to re-fold, and/or is more stable under a variety of conditions. The invention also provides GFP, streptavidin, and GST variants with an increased theoretical net charge created by the inventive technology. Kits are also provided for carrying out such modifications on any protein of interest.Type: GrantFiled: June 1, 2007Date of Patent: October 6, 2015Assignee: President and Fellows of Harvard CollegeInventors: David R. Liu, Kevin John Phillips, Michael S. Lawrence
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Publication number: 20120129759Abstract: Aggregation is a major cause of the misbehavior of proteins. A system for modifying a protein to create a more stable variant is provided. The method involves identifying non-conserved hydrophobic amino acid residues on the surface of a protein, suitable for mutating to more hydrophilic residues (e.g., charged amino acids). Any number of residues on the surface may be changed to create a variant that is more soluble, resistant to aggregation, has a greater ability to re-fold, and/or is more stable under a variety of conditions. The invention also provides GFP, streptavidin, and GST variants with an increased theoretical net charge created by the inventive technology. Kits are also provided for carrying out such modifications on any protein of interest.Type: ApplicationFiled: December 30, 2011Publication date: May 24, 2012Applicant: President and Fellows of Harvard CollegeInventors: David R. Liu, Kevin John Phillips, Michael S. Lawrence
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Publication number: 20100209994Abstract: Aggregation is a major cause of the misbehavior of proteins. A system for modifying a protein to create a more stable variant is provided. The method involves identifying non-conserved hydrophobic amino acid residues on the surface of a protein, suitable for mutating to more hydrophilic residues (e.g., charged amino acids). Any number of residues on the surface may be changed to create a variant that is more soluble, resistant to aggregation, has a greater ability to re-fold, and/or is more stable under a variety of conditions. The invention also provides GFP, streptavidin, and GST variants with an increased theoretical net charge created by the inventive technology. Kits are also provided for carrying out such modifications on any protein of interest.Type: ApplicationFiled: June 1, 2007Publication date: August 19, 2010Applicant: President and Fellows of Harvard CollegeInventors: David R. Liu, Kevin John Phillips, Michael S. Lawrence
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Patent number: 3997137Abstract: Spacecraft nutation caused by applying attitude and/or orbit control forces to a spacecraft along an axis which does not pass through the spacecraft's center of gravity is minimized by a signal responsive control system which first operates the attitude and/or orbit control forces for a predetermined time period and automatically after an appropriate non-operating time period, the attitude and/or orbit control forces are again operated for the same predetermined time period.Type: GrantFiled: December 10, 1973Date of Patent: December 14, 1976Assignee: RCA CorporationInventor: Kevin John Phillips